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51.发明申请公开(公告)号：US20150152097A1
公开(公告)日：2015-06-04
申请号：US14559828
申请日：2014-12-03
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: C07D417/14
CPC classification number: A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US09035047B2
公开(公告)日：2015-05-19
申请号：US13868951
申请日：2013-04-23
Applicant: AbbVie Inc.
Inventor： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D413/14 , A61K31/5377 , C07D209/42 , C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , C07D401/04 , C07D413/12
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
Abstract translation: 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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53.发明授权公开(公告)号：US08952157B2
公开(公告)日：2015-02-10
申请号：US13952278
申请日：2013-07-26
Inventor： Hong Ding , George A. Doherty , Steven W. Elmore , Laura Hexamer , Aaron R. Kunzer , Cheol-Min Park , Xiahong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Le Wang , Michael D. Wendt , Peter Edward Czabotar , Guillaume Laurent Lessene , Peter Malcolm Colman
IPC: C07D241/12 , C07D401/10 , C07D401/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D309/08
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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54.发明授权公开(公告)号：US08889675B2
公开(公告)日：2014-11-18
申请号：US13649900
申请日：2012-10-11
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/54 , C07D401/04 , C07D417/14 , C07D471/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20250092062A1
公开(公告)日：2025-03-20
申请号：US18592020
申请日：2024-02-29
Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
Inventor： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC: C07D495/16 , A61K31/519 , A61K45/06 , A61P35/00 , A61P35/02 , C07D491/18 , C07D491/22 , C07D495/18 , C07D495/22
Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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Patent Agency Ranking
56.发明申请公开(公告)号：US20210228565A1
公开(公告)日：2021-07-29
申请号：US17022693
申请日：2020-09-16
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20200246323A1
公开(公告)日：2020-08-06
申请号：US16412729
申请日：2019-05-15
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Erwin R. Boghaert , Milan Bruncko , George Doherty , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-fu Tao , Xilu Wang , Dennle S. Welch
IPC: A61K31/4545 , A61K47/68
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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公开(公告)号：US20200239553A1
公开(公告)日：2020-07-30
申请号：US16675784
申请日：2019-11-06
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC: C07K16/18 , C07D417/14 , C07D487/04 , C07D513/04 , A61K47/68
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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59.发明申请公开(公告)号：US20190119247A1
公开(公告)日：2019-04-25
申请号：US15993521
申请日：2018-05-30
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D403/12 , C07D209/82 , A61K31/496 , C07D401/14 , C07D519/00 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20170182179A1
公开(公告)日：2017-06-29
申请号：US14963512
申请日：2015-12-09
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Erwin R. Boghaert , Milan Bruncko , George Doherty , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch
IPC: A61K47/48 , A61K31/4545 , C07D513/04 , C07K19/00
CPC classification number: A61K31/4545 , A61K47/6803 , A61K47/6807 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6889
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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