公开(公告)号：US09532872B2

公开(公告)日：2017-01-03

申请号：US14553459

申请日：2014-11-25

Applicant: Boston Scientific Scimed, Inc.

Inventor： Amr Salahieh ,  Hans F. Valencia ,  Brian D. Brandt ,  Claudio Argento ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Daniel K. Hildebrand ,  Dwight P. Morejohn ,  Tom Saul

IPC: A61F2/24 ,  A61B17/064 ,  A61B17/068 ,  A61F2/90 ,  A61B17/221 ,  A61B17/22 ,  A61F2/95

CPC classification number: A61F2/2427 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/221 ,  A61B2017/22035 ,  A61B2017/2215 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/90 ,  A61F2002/9534 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/001

Abstract: The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.

Abstract translation: 本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。 在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件 元件处于第二配置并且从输送系统释放植入物。

公开(公告)号：US09474598B2

公开(公告)日：2016-10-25

申请号：US13645727

申请日：2012-10-05

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Peter W. Gregg ,  David J. Paul ,  Brian D. Brandt ,  Rajan Khokhar

IPC: A61F2/24 ,  A61L27/14

CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2250/0069 ,  A61L27/14 ,  F04C2270/0421

Abstract: The disclosure pertains to profile reduction seals associated with heart valve replacements which may reduce or eliminate paravalvular regurgitation and methods of fabricating such seals. The generally cylindrical multilayer seals of the disclosure include a crown-like end and reinforcing elements which facilitate compression of the seal and associated device by minimizing bunching of the seal as it enters a delivery system.

Abstract translation: 本公开涉及与心脏瓣膜置换相关的轮廓减少密封，其可以减少或消除瓣膜瓣反流以及制造这种密封的方法。 本公开的大致圆柱形的多层密封件包括冠状端部和加强元件，其通过使密封件进入输送系统时的聚束最小化而有助于密封件和相关联的装置的压缩。

公开(公告)号：US20160135951A1

公开(公告)日：2016-05-19

申请号：US15006227

申请日：2016-01-26

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Ulrich R. Haug ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Robert A. Geshlider ,  Jeff A. Krolik

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2002/9528 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/006

Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a delivery catheter having a diameter of 21 french or less; an expandable anchor disposed within the delivery catheter; and a replacement valve disposed within the delivery catheter. The invention also includes a method for endovascularly replacing a heart valve of a patient. In some embodiments the method includes the steps of: inserting a catheter having a diameter no more than 21 french into the patient; endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve through the catheter; and deploying the anchor and the replacement valve.

Abstract translation: 用于血管内替换患者心脏瓣膜的装置，包括：直径为21法郎或更小的输送导管; 布置在输送导管内的可扩张锚; 以及设置在输送导管内的置换瓣膜。 本发明还包括用于血管内置换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将具有不超过21个法兰的直径的导管插入患者体内; 通过导管将血管内递送更换瓣膜和可扩张锚固件到心脏瓣膜附近; 并部署锚杆和更换阀。

公开(公告)号：US09320599B2

公开(公告)日：2016-04-26

申请号：US14494922

申请日：2014-09-24

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Amr Salahieh ,  Jean-Pierre Dueri ,  Hans F. Valencia ,  Daniel K. Hildebrand ,  Brian D. Brandt ,  Dwight P. Morejohn ,  Claudio Argento ,  Tom Saul ,  Ulrich R. Haug

IPC: A61F2/24 ,  A61F2/90 ,  A61F2/95

CPC classification number: A61F2/2439 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/90 ,  A61F2002/9528 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/006

Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.

Abstract translation: 本发明包括用于血管内置换患者心脏瓣膜的方法和装置。 本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力， 锚或锚的部分。 本发明的另一方面提供了一种包括置换阀的装置; 锚点 以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

公开(公告)号：US20140373334A1

公开(公告)日：2014-12-25

申请号：US14482214

申请日：2014-09-10

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Randy S. Gamarra ,  David S. Tung ,  Benjamin Sutton ,  Takashi Ino ,  Joshua Wallin ,  Brian D. Brandt

IPC: A61B17/00 ,  A61F2/24

CPC classification number: A61F2/2436 ,  A61B17/00234 ,  A61B2017/00526 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2002/9517 ,  A61M25/0009 ,  A61M25/0026 ,  A61M25/09016 ,  Y10T29/49826

Abstract: An elongated member and a method of manufacturing an elongated member may include first, second, and third elongated rod mandrels. The first, second, and third elongated rod mandrels may be fixed together at predetermined proximal and distal locations and at a ball tip. The first, second, and third rod mandrels may be disposed within a tubular coupling element and fixed to the tubular coupling element at the ball tip. The tubular coupling element may be placed into abutment with and fixed to the distal end of an elongated shaft.

Abstract translation: 细长构件和制造细长构件的方法可以包括第一，第二和第三细长杆心轴。 第一，第二和第三细长杆心轴可以在预定的近端和远端位置处以及球尖固定在一起。 第一，第二和第三杆心轴可以设置在管状联接元件内并且在球头处固定到管状联接元件。 管状联接元件可以放置成与细长轴的远端邻接并固定到细长轴的远端。