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51.发明申请公开(公告)号：US20110003295A1
公开(公告)日：2011-01-06
申请号：US12757921
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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公开(公告)号：US07432049B2
公开(公告)日：2008-10-07
申请号：US10085783
申请日：2002-02-28
申请人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
发明人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The invention provides for nucleic acid sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild osteoarthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these nucleic acid sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the nucleic acids of the invention or alter the anabolic level of a chondrocyte.
摘要翻译： 本发明提供在以下任何发育和疾病阶段的软骨细胞中表达的核酸序列：胎儿，正常，轻度骨关节炎，中度骨关节炎，标记和骨关节炎。 本发明还涉及包含这些核酸序列的任何组合的阵列和组合物。 本发明还提供了使用本发明的阵列来诊断骨关节炎的方法。 本发明还提供了鉴定改变本发明的核酸的表达水平或改变软骨细胞的合成代谢水平的治疗剂的方法。
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53.发明申请公开(公告)号：US20070031841A1
公开(公告)日：2007-02-08
申请号：US10601518
申请日：2003-06-20
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , G16B25/00 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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54.发明申请Method for the detection of coronary artery disease related gene transcripts in blood 审中-公开检测血液中冠状动脉疾病相关基因转录物的方法公开(公告)号：US20060134635A1
公开(公告)日：2006-06-22
申请号：US10802875
申请日：2004-03-12
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G16B25/00
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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55.发明授权公开(公告)号：US08110358B2
公开(公告)日：2012-02-07
申请号：US12757931
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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56.发明申请METHODS, KITS AND COMPOSITIONS FOR DETERMINING SEVERITY AND SURVIVAL OF HEART FAILURE IN A SUBJECT 审中-公开方法，用于确定受试者心脏缺陷严重程度和存活率的组合物公开(公告)号：US20110223594A1
公开(公告)日：2011-09-15
申请号：US13002007
申请日：2009-06-29
申请人： Peter Vanburen , Jun Ma , Choong-Chin Liew
发明人： Peter Vanburen , Jun Ma , Choong-Chin Liew
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The application provides a method of determining a severity of heart failure in a human test subject, by determining a level of RNA encoded by one or more heart failure marker genes in blood of the test subject compared to controls. The application also provides a method of determining survival outcome and allows the ranking of test subjects based on the level of RNA encoded by one or more survival associated genes.
摘要翻译： 该应用提供了通过测定与对照相比测试受试者的血液中的一种或多种心力衰竭标记基因编码的RNA水平来确定人类测试受试者的心力衰竭严重程度的方法。 该应用还提供了一种确定存活结果的方法，并且允许基于由一个或多个存活相关基因编码的RNA的水平来测试受试者的排名。
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公开(公告)号：US20110003298A1
公开(公告)日：2011-01-06
申请号：US12757931
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
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公开(公告)号：US20110003294A1
公开(公告)日：2011-01-06
申请号：US12757918
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
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公开(公告)号：US20100203520A1
公开(公告)日：2010-08-12
申请号：US12587385
申请日：2009-10-05
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
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公开(公告)号：US20100203519A1
公开(公告)日：2010-08-12
申请号：US12587384
申请日：2009-10-06
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
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