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公开(公告)号：US09066538B2
公开(公告)日：2015-06-30
申请号：US13048584
申请日：2011-03-15
申请人： Gong Chen , Michael Francis Dube , Daniel Verdin Cantrell , Jerry Wayne Marshall , Frank Kelley St. Charles , Huamin Gan , Cheryl Cooper Scott , Barry Smith Fagg
发明人： Gong Chen , Michael Francis Dube , Daniel Verdin Cantrell , Jerry Wayne Marshall , Frank Kelley St. Charles , Huamin Gan , Cheryl Cooper Scott , Barry Smith Fagg
CPC分类号： A24B3/12 , A24B3/00 , A24B15/183 , A24B15/22
摘要： A method is provided for curing tobacco. The method includes steps of wilting, bruising, aerating, and drying tobacco, where each of the steps is measured in hours or days rather than months. In some aspects, aeration may take two to twelve hours or less. In some aspects, the entire curing method may be completed in 24 hours or less.
摘要翻译： 提供了一种固化烟草的方法。 该方法包括萎ting，瘀伤，充气和干燥烟草的步骤，其中每个步骤以数小时或数天而不是几个月测量。 在某些方面，曝气可能需要2至12小时或更短时间。 在一些方面，整个固化方法可以在24小时或更短时间内完成。
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公开(公告)号：US20120234334A1
公开(公告)日：2012-09-20
申请号：US13048584
申请日：2011-03-15
申请人： Gong Chen , Michael Francis Dube , Daniel Verdin Cantrell , Jerry Wayne Marshall , Frank Kelley St. Charles , Huamin Gan , Cheryl Cooper Scott , Barry Smith Fagg
发明人： Gong Chen , Michael Francis Dube , Daniel Verdin Cantrell , Jerry Wayne Marshall , Frank Kelley St. Charles , Huamin Gan , Cheryl Cooper Scott , Barry Smith Fagg
CPC分类号： A24B3/12 , A24B3/00 , A24B15/183 , A24B15/22
摘要： A method is provided for curing tobacco. The method includes steps of wilting, bruising, aerating, and drying tobacco, where each of the steps is measured in hours or days rather than months. In some aspects, aeration may take two to twelve hours or less. In some aspects, the entire curing method may be completed in 24 hours or less.
摘要翻译： 提供了一种固化烟草的方法。 该方法包括萎ting，瘀伤，充气和干燥烟草的步骤，其中每个步骤以数小时或数天而不是几个月测量。 在某些方面，曝气可能需要2至12小时或更短时间。 在一些方面，整个固化方法可以在24小时或更短时间内完成。
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公开(公告)号：US07906278B2
公开(公告)日：2011-03-15
申请号：US10242535
申请日：2002-09-12
申请人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
发明人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
摘要翻译： 本发明涉及鉴定和选择在鉴定具有骨关节炎（OA）的个体中特别有利的序列。 本发明还提供了特别可用于诊断个体骨关节炎进展程度以及鉴定OA的新型治疗靶标的序列选择。 本发明进一步提供这些序列作为诊断疾病进展并监测治疗方案疗效的工具的用途。
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4.发明申请公开(公告)号：US20090048115A1
公开(公告)日：2009-02-19
申请号：US12152163
申请日：2008-05-13
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/158
摘要： The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
摘要翻译： 本发明涉及鉴定和选择在鉴定具有骨关节炎（OA）的个体中特别有利的序列。 本发明还提供了特别可用于诊断个体骨关节炎进展程度以及鉴定OA的新型治疗靶标的序列选择。 本发明进一步提供这些序列作为诊断疾病进展并监测治疗方案疗效的工具的用途。
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5.发明授权Diagnosis of mild osteoarthritis by determination of TNFAIP6 and TGFBI RNA levels 失效通过测定TNFAIP6和TGFBI RNA水平诊断轻度骨关节炎公开(公告)号：US07452667B2
公开(公告)日：2008-11-18
申请号：US10661242
申请日：2003-09-12
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/158
摘要： The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
摘要翻译： 本发明涉及鉴定和选择在鉴定具有骨关节炎（OA）的个体中特别有利的序列。 本发明还提供了特别可用于诊断个体骨关节炎进展程度以及鉴定OA的新型治疗靶标的序列选择。 本发明进一步提供这些序列作为诊断疾病进展并监测治疗方案疗效的工具的用途。
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公开(公告)号：US20130269719A1
公开(公告)日：2013-10-17
申请号：US13444272
申请日：2012-04-11
CPC分类号： A24B15/20 , A24B15/245
摘要： A method of modifying the content of certain chemical compounds in tobacco materials is provided, the method including treatment of a tobacco plant component with at least one probiotic. For example, the method may modify the asparagine content in tobacco materials, which can result in a modification in acrylamide production when the tobacco material is exposed to elevated temperatures. The type of tobacco plant component treated according to the invention can be a tobacco seed, a tobacco seedling, an immature live plant, a mature live plant, a harvested plant, or a portion thereof. Examples of probiotics include probiotic species of the genera bifidobacterium, lactobacillus, enterococcus, proionobacterium, bacillus, saccharomyces, streptococcus, and mixtures thereof. Smoking articles and other tobacco products including such probiotic-treated tobacco materials are also provided.
摘要翻译： 提供了一种改变烟草材料中某些化合物含量的方法，该方法包括用至少一种益生菌处理烟草植物成分。 例如，该方法可以改变烟草材料中的天冬酰胺含量，当烟草材料暴露于升高的温度时，这可能导致丙烯酰胺生产的改变。 根据本发明处理的烟草植物组分的类型可以是烟草种子，烟草幼苗，未成熟的活植物，成熟的活植物，收获的植物或其一部分。 益生菌的实例包括双歧杆菌属，乳杆菌属，肠球菌属，恶杆菌属，芽孢杆菌属，酵母属，链球菌属的益生菌种类及其混合物。 还提供了吸烟制品和其他烟草制品，包括这种益生菌处理的烟草材料。
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公开(公告)号：US20120279510A1
公开(公告)日：2012-11-08
申请号：US13491319
申请日：2012-06-07
摘要： A curing process for providing cured tobacco. Tobacco in green or yellow form can be cured by first placing that tobacco in intimate contact with at least one sugar and/or salt, and subjecting that tobacco to curing conditions. The resulting cured tobacco so provided can be used for the production of tobacco products, and in particular, smokeless tobacco products.
摘要翻译： 用于提供固化烟草的固化方法。 通过首先将烟草与至少一种糖和/或盐紧密接触并使烟草经受固化条件，可以治愈绿色或黄色的烟草。 如此提供的所得固化烟草可用于生产烟草制品，特别是无烟烟草制品。
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公开(公告)号：US08186360B2
公开(公告)日：2012-05-29
申请号：US11696416
申请日：2007-04-04
申请人： Jerry Wayne Marshall , Susan Marlene Adams , Dwayne William Beeson , Ernest L. Cerny, III , Keisha Renee Willingham
发明人： Jerry Wayne Marshall , Susan Marlene Adams , Dwayne William Beeson , Ernest L. Cerny, III , Keisha Renee Willingham
IPC分类号： A24D3/14
摘要： A cigarette is provided that includes a rod of smokable material circumscribed by an outer wrapping material and a filter element, which may include an adsorbent material such as activated carbon, attached to one end of the rod of smokable material. The smokable material includes at least about 5 percent by weight of a dark air-cured tobacco, based on the dry weight of the smokable material, blended with additional tobacco materials such as flue-cured tobacco, burley tobacco, Oriental tobacco, Maryland tobacco, and mixtures thereof.
摘要翻译： 提供了一种香烟，其包括由外包装材料包围的可吸烟材料的杆和过滤元件，过滤元件可以包括附着在可吸收材料的杆的一端的吸附材料，例如活性炭。 可吸烟材料包括至少约5重量％的黑色干燥烟草，基于可吸烟材料的干重，与另外的烟草材料如烤烟，白肋烟，东方烟草，马里兰州烟草， 及其混合物。
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公开(公告)号：US08142998B2
公开(公告)日：2012-03-27
申请号：US12554141
申请日：2009-09-04
申请人： Choong-Chin Liew , Thomas Yager , Adam Dempsey , Samuel Chao , Hongwei Zhang , Wayne Marshall
发明人： Choong-Chin Liew , Thomas Yager , Adam Dempsey , Samuel Chao , Hongwei Zhang , Wayne Marshall
CPC分类号： G01N33/564 , C12N15/113 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/15 , C12Q1/6883 , C12Q2600/158 , G01N2800/105 , G01N2800/52
摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing the polynucleotides and proteins and the use of the polynucleotides and proteins. The biomarker products can be used to identify therapeutic targets for osteoarthritis, and compounds that bind and/or modulate gene activity.
摘要翻译： 本发明涉及新型生物标志物的鉴定和选择以及在骨关节炎和/或在骨关节炎的特定阶段中差异表达的新型生物标志物组合的鉴定和选择，以及选择新型生物标志物组合的方法。 测量生物标志物的产物和生物标志物的组合在以下一个或多个中表现出特别的优点：（a）诊断个体具有关节炎，（b）区分两个阶段的骨关节炎（OA）和（c） 诊断个人具有特定的OA阶段。 与生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质在本发明的范围内，以及含有多核苷酸和蛋白质的试剂盒以及多核苷酸和蛋白质的用途。 生物标记产物可用于鉴定骨关节炎的治疗靶点，以及结合和/或调节基因活性的化合物。
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公开(公告)号：US20100143916A1
公开(公告)日：2010-06-10
申请号：US12554141
申请日：2009-09-04
申请人： Choong-Chin Liew , Thomas Yager , Adam Dempsey , Samuel Chao , Hongwei Zhang , Wayne Marshall
发明人： Choong-Chin Liew , Thomas Yager , Adam Dempsey , Samuel Chao , Hongwei Zhang , Wayne Marshall
IPC分类号： C12Q1/68
CPC分类号： G01N33/564 , C12N15/113 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/15 , C12Q1/6883 , C12Q2600/158 , G01N2800/105 , G01N2800/52
摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). As would be understood, in order to measure the products of biomarkers of the invention, polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease progression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of compounds that bind and/or modulate the activity of the genes of the invention. The compounds identified via such methods are useful for the development of assays to study osteoarthritis and osteoarthritis progression. Further, the compounds identified via such methods are useful as lead compounds in the development of prophylactic and therapeutic compositions for the prevention, treatment, management and/or amelioration of osteoarthritis or a symptom thereof.
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