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1.发明授权公开(公告)号：US08669058B2
公开(公告)日：2014-03-11
申请号：US13584369
申请日：2012-08-13
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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2.发明授权Method, computer readable medium, and system for determining a probability of colorectal cancer in a test subject 失效方法，计算机可读介质和用于确定测试对象中结肠直肠癌概率的系统公开(公告)号：US08249814B2
公开(公告)日：2012-08-21
申请号：US12091049
申请日：2006-10-23
申请人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
发明人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G06F19/12 , G06F19/18 , G06F19/20 , G06F19/24 , G16H50/30 , Y02A90/26
摘要： Disclosed is a method of testing for colorectal cancer in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has colorectal cancer. Also disclosed are kits for measuring data corresponding to the products of selected biomarkers, and kits and methods of monitoring therapeutic efficacy of treatments for colorectal cancer.
摘要翻译： 公开了一种通过提供对应于所选生物标志物的产物水平的数据并将数据应用于配方以提供测试个体是否具有结肠直肠癌的指示来测试测试个体中的结肠直肠癌的方法。 还公开了用于测量与所选生物标志物的产物相对应的数据的试剂盒，以及用于监测治疗结直肠癌的治疗功效的试剂盒和方法。
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公开(公告)号：US08133674B2
公开(公告)日：2012-03-13
申请号：US12757928
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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4.发明授权公开(公告)号：US08114597B2
公开(公告)日：2012-02-14
申请号：US12757921
申请日：2010-04-09
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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5.发明申请Method and apparatus for determining a probability of colorectal cancer in a subject 有权用于确定受试者中结肠直肠癌概率的方法和装置公开(公告)号：US20100099086A1
公开(公告)日：2010-04-22
申请号：US12384914
申请日：2009-04-10
申请人： Choong-Chin Liew , Samuel Chao
发明人： Choong-Chin Liew , Samuel Chao
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/166 , G01N33/57419 , G01N2800/50 , G01N2800/56 , G06F19/12 , G06F19/20 , G06F19/24
摘要： A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1: determining a level of RNA encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of RNA encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of RNA encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer.
摘要翻译： 公开了一种确定人类受试者具有结肠直肠癌而不是不具有结肠直肠癌的可能性的方法。 对于选自ANXA3，CLEC4D，IL2RB，LMNB1，PRRG4，TNFAIP6和VNN1的一组或多种基因的每个基因，该方法包括：测定受试对象的血液中基因编码的RNA水平 从而生成测试数据; 提供表示具有结肠直肠癌的人类对照受试者的血液中基因编码的RNA水平的阳性对照数据，并提供表示不具有结肠直肠癌的人类对照受试者的血液中由该基因编码的RNA水平的阴性对照数据; 并且确定测试数据对应于阳性对照数据而不是阴性对照数据的概率，其中测试数据对应于阳性对照数据而不是阴性对照数据的概率表示测试对象具有 结肠直肠癌相对于没有结肠直肠癌。
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6.发明授权公开(公告)号：US07473528B2
公开(公告)日：2009-01-06
申请号：US10813097
申请日：2004-03-30
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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7.发明申请Method and apparatus for correlating levels of biomarker products with disease 失效将生物标记产物与疾病相关的方法和装置公开(公告)号：US20070213939A1
公开(公告)日：2007-09-13
申请号：US11585666
申请日：2006-10-23
申请人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
发明人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
IPC分类号： G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G06F19/12 , G06F19/18 , G06F19/20 , G06F19/24 , G16H50/30 , Y02A90/26
摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.
摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。
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公开(公告)号：US20070054281A1
公开(公告)日：2007-03-08
申请号：US11272125
申请日：2005-11-10
申请人： Choong-Chin Liew , Hongwei Zhang , K. Marshall
发明人： Choong-Chin Liew , Hongwei Zhang , K. Marshall
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： Described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having osteoarthritis. Also described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having a particular stage of Osteoarthritis. Also presented are methods for quantitating the biomarkers in a sample from an individual, for use in the diagnosis and/or prognosis of osteoarthritis.
摘要翻译： 描述了与识别，选择和使用生物标志物有关的组合物和方法，其在鉴定具有骨关节炎的个体中具有特别的优点。 还描述了与识别，选择和使用生物标志物有关的组合物和方法，其在鉴定具有特定阶段的骨关节炎的个体中具有特别的优点。 还提出了用于定量来自个体的样品中的生物标志物用于骨关节炎的诊断和/或预后的方法。
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9.发明申请Methods for the detection of brain-specific gene transcripts in blood and uses thereof 审中-公开用于检测血液中脑特异性基因转录物的方法及其用途公开(公告)号：US20050191637A1
公开(公告)日：2005-09-01
申请号：US10803737
申请日：2004-03-18
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , Y10T436/143333
摘要： The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物的检测和测量。 具体提供的是使用组织特异性引物检测，诊断和监测疾病的一滴血液进行的RT-PCR分析。 本发明还描述了通过其描绘序列和/或定量疾病相关基因的表达水平可以立即进行疾病诊断/预后测试或评估特定治疗方案的效果的方法。
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10.发明申请Method for the detection of Alzheimer's disease related gene transcripts in blood 审中-公开检测血液中阿尔茨海默病相关基因转录物的方法公开(公告)号：US20050079514A1
公开(公告)日：2005-04-14
申请号：US10812827
申请日：2004-03-30
申请人： Choong-Chin Liew
发明人： Choong-Chin Liew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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