公开(公告)号：US20110177998A1

公开(公告)日：2011-07-21

申请号：US12668712

申请日：2008-07-11

申请人： Ronen Shemesh ,  Zurit Levine ,  Amir Toporik ,  Chen Hermesh ,  Yossef Kliger ,  Eyal Gofer ,  Assaf Wool ,  Dvir Dahary ,  Yossi Cohen

发明人： Ronen Shemesh ,  Zurit Levine ,  Amir Toporik ,  Chen Hermesh ,  Yossef Kliger ,  Eyal Gofer ,  Assaf Wool ,  Dvir Dahary ,  Yossi Cohen

IPC分类号： A61K38/17 ,  C12N9/96 ,  A61P11/06 ,  A61P9/00 ,  A61P9/12 ,  A61P9/10 ,  A61P19/08 ,  A61P25/00 ,  A61P17/02 ,  A61P35/00 ,  A61K38/08 ,  C07K14/435 ,  C07K7/06 ,  C07K16/18

CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K7/06 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C07K2317/34

摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。

公开(公告)号：US20100322938A1

公开(公告)日：2010-12-23

申请号：US12863864

申请日：2009-01-22

申请人： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

发明人： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04 ,  A61P25/28

CPC分类号： C07K14/775 ,  A61K38/00

摘要： Clusterin-derived peptides or homologues or derivatives thereof, pharmaceutical compositions including the same, methods of manufacturing the peptides, homologues, derivatives thereof and compositions including the same, and methods of treating conditions including administering the peptides, homologues, derivatives thereof and compositions including the same, are provided. Also provided are nucleotide sequences encoding the peptides, homologues, derivatives thereof and compositions including the same, antibodies directed to epitopes thereof and fusion proteins including the same

摘要翻译： 来自Clusterin的肽或其同系物或衍生物，包含其的药物组合物，制备肽的方法，同系物，其衍生物和包含其的组合物，以及治疗包括给予所述肽，同系物，衍生物和包括 相同，被提供。 还提供了编码肽，同系物，其衍生物和包含其的组合物的核苷酸序列，针对其表位的抗体和包含其的融合蛋白

公开(公告)号：US20100248270A1

公开(公告)日：2010-09-30

申请号：US12623957

申请日：2009-11-23

申请人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

发明人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

IPC分类号： G01N33/53 ,  C07K16/00

CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

公开(公告)号：US20100068736A1

公开(公告)日：2010-03-18

申请号：US12557253

申请日：2009-09-10

申请人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Ayalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

发明人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Ayalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

IPC分类号： G01N33/53 ,  C07K2/00 ,  C07K16/00 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.

摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。

公开(公告)号：US07667001B1

公开(公告)日：2010-02-23

申请号：US11978554

申请日：2007-10-30

申请人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Avalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

发明人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Avalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

IPC分类号： C07K16/00

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.

摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。

公开(公告)号：US07345142B2

公开(公告)日：2008-03-18

申请号：US11043824

申请日：2005-01-27

申请人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

发明人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

IPC分类号： A61K38/00

CPC分类号： G01N33/6893 ,  C07K14/705 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

公开(公告)号：US20060263786A1

公开(公告)日：2006-11-23

申请号：US11050875

申请日：2005-01-27

申请人： Rotem Sorek ,  Michal Ayalon-Soffer ,  Dvir Dahary ,  Amit Novik ,  Amir Toporik ,  Alexander Diber ,  Guy Kol ,  Sarah Pollock ,  Zurit Levine ,  Gad Coiocaru ,  Ronen Shemesh ,  Yossi Cohen ,  Osnat Sella-Tavor ,  Shirley Sameah-Greenwald ,  Shira Walach

发明人： Rotem Sorek ,  Michal Ayalon-Soffer ,  Dvir Dahary ,  Amit Novik ,  Amir Toporik ,  Alexander Diber ,  Guy Kol ,  Sarah Pollock ,  Zurit Levine ,  Gad Coiocaru ,  Ronen Shemesh ,  Yossi Cohen ,  Osnat Sella-Tavor ,  Shirley Sameah-Greenwald ,  Shira Walach

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： C07K14/4748 ,  C12Q1/6886 ,  G01N33/57419

摘要： Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between colon cancer and non-cancerous states.

摘要翻译： 结肠癌的新型标志物既敏感又准确。 与正常结肠组织相反，这些标志物特异性地在结肠癌中过度表达。 这些标记物单独或组合在患者样本中的测量提供了诊断者可以与结肠癌可能诊断相关的信息。 本发明的标记物单独或组合显示结肠癌与非癌状态之间的高度差异检测。

公开(公告)号：US20050202531A1

公开(公告)日：2005-09-15

申请号：US10979178

申请日：2004-11-03

申请人： Amir Toporik

发明人： Amir Toporik

IPC分类号： C07H21/04 ,  C07K14/74 ,  C07K16/28

CPC分类号： C07K14/70578

摘要： Provided are isolated CD40 splice variants that include altered internal sequences and unique tail sequences relative to previously described CD40 protein sequences. Also provided are fragments of the CD40 splice variants comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical compositions comprising the protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are also disclosed. The present invention additionally relates to recombinant expression vectors that include the nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.

摘要翻译： 提供了相对于先前描述的CD40蛋白序列的分离的CD40剪接变体，其包括改变的内部序列和唯一的尾部序列。 还提供了CD40剪接变体的片段，其包含至少10个氨基酸，包括唯一尾部序列的至少4个氨基酸; 公开了具有至少10个氨基酸和90％同一性的独特的尾部序列及其同源物，并且与这些蛋白质上的表位结合的抗体。 还公开了包含蛋白质，抗体，编码这种蛋白质的分离的核酸分子和包含此类核酸分子的药物组合物的药物组合物。 本发明还涉及包含核酸分子和包含这种重组表达载体的宿主细胞的重组表达载体。 在样本中检测体外的方法，公开了编码这种蛋白质的这些蛋白质或转录物的存在和/或数量，作为用于进行该方法的试剂盒和试剂。 公开了调节个体中CD40-CD154相互作用的方法。