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公开(公告)号：US20110177998A1
公开(公告)日：2011-07-21
申请号：US12668712
申请日：2008-07-11
申请人： Ronen Shemesh , Zurit Levine , Amir Toporik , Chen Hermesh , Yossef Kliger , Eyal Gofer , Assaf Wool , Dvir Dahary , Yossi Cohen
发明人： Ronen Shemesh , Zurit Levine , Amir Toporik , Chen Hermesh , Yossef Kliger , Eyal Gofer , Assaf Wool , Dvir Dahary , Yossi Cohen
IPC分类号： A61K38/17 , C12N9/96 , A61P11/06 , A61P9/00 , A61P9/12 , A61P9/10 , A61P19/08 , A61P25/00 , A61P17/02 , A61P35/00 , A61K38/08 , C07K14/435 , C07K7/06 , C07K16/18
CPC分类号： C07K14/472 , A61K38/00 , C07K7/06 , C07K14/47 , C07K14/78 , C07K16/18 , C07K2317/34
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US08492329B2
公开(公告)日：2013-07-23
申请号：US12668712
申请日：2008-07-11
申请人： Ronen Shemesh , Zurit Levine , Amir Toporik , Chen Hermesh , Yossef Klinger , Eyal Gofer , Assaf Wool , Dvir Dahary , Yossi Cohen
发明人： Ronen Shemesh , Zurit Levine , Amir Toporik , Chen Hermesh , Yossef Klinger , Eyal Gofer , Assaf Wool , Dvir Dahary , Yossi Cohen
CPC分类号： C07K14/472 , A61K38/00 , C07K7/06 , C07K14/47 , C07K14/78 , C07K16/18 , C07K2317/34
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
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3.发明授权Method of treating an ischemia-reperfusion injury-related disorder by administering GPCR ligands 有权通过施用GPCR配体治疗缺血再灌注损伤相关疾病的方法公开(公告)号：US08828940B2
公开(公告)日：2014-09-09
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US07884180B2
公开(公告)日：2011-02-08
申请号：US11901975
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/00 , A61K31/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US20090054342A1
公开(公告)日：2009-02-26
申请号：US11901975
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US20120129776A1
公开(公告)日：2012-05-24
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/08 , C07K14/47 , C07K7/08 , C07K2/00 , C07H21/00 , A61K48/00 , C07K16/18 , A61P9/12 , A61P9/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P3/00 , A61P11/00 , A61P17/02 , A61P19/08 , A61P13/02 , A61P15/00 , A61P7/00 , A61P37/00 , A61P35/00 , A61P13/12 , A61P17/14 , A61P21/00 , A61P9/04 , C07K19/00 , A61P7/02 , A61K38/17 , C07K7/06
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US08349801B2
公开(公告)日：2013-01-08
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating myocardial and ischemic disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的心肌和缺血性疾病。
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公开(公告)号：US20110104217A1
公开(公告)日：2011-05-05
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/16 , A61P17/02 , A61K38/08 , A61K38/10 , A61K9/00 , A61P9/00 , A61P9/04 , A61P9/12 , A61P7/02 , A61P9/10 , A61P19/02 , A61P1/04 , A61P11/06 , A61P29/00 , A61P25/00
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US20100075891A1
公开(公告)日：2010-03-25
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。
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