公开(公告)号：US20050281783A1

公开(公告)日：2005-12-22

申请号：US10966483

申请日：2004-10-15

Applicant: Michael Kinch ,  Peter Kiener ,  Elizabeth Bruckheimer ,  Thomas Dubensky ,  David Cook

Inventor： Michael Kinch ,  Peter Kiener ,  Elizabeth Bruckheimer ,  Thomas Dubensky ,  David Cook

IPC: A61K20060101 ,  A61K39/00 ,  A61K48/00 ,  C12N1/21

CPC classification number: A61K39/0011 ,  A61K2039/522 ,  A61K2039/523

Abstract: The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly metastatic cancer and cancers of T cell origin, and hyperproliferative diseases involving EphA2-expressing cells. The methods of the invention entail the use of a Listeria-based EphA2 vaccine. The invention also provides pharmaceutical compositions comprising one or more Listeria-based vaccines of the invention either alone or in combination with one or more other agents useful for cancer therapy. In certain aspects of the invention, the methods entail eliciting both CD4+ and CD8+ T-cell responses against EphA2 and/or EphA2-expressing cells.

Abstract translation: 本发明涉及设计用于治疗，治疗或预防癌症，特别是转移性癌症和T细胞来源的癌症以及涉及EphA2表达细胞的过度增殖性疾病的方法和组合物。 本发明的方法需要使用基于李斯特菌的EphA2疫苗。 本发明还提供包含本发明的一种或多种基于李斯特菌的疫苗的药物组合物，其单独或与一种或多种其它可用于癌症治疗的试剂组合。 在本发明的某些方面，所述方法需要引起针对EphA2和/或EphA2表达细胞的CD4 +和/或CD8 + T细胞应答。

公开(公告)号：US20050160179A1

公开(公告)日：2005-07-21

申请号：US10762856

申请日：2004-01-21

Applicant: Alvaro Retana ,  David Cook ,  Russell White ,  Yi Yang ,  Madhavi Chandra

Inventor： Alvaro Retana ,  David Cook ,  Russell White ,  Yi Yang ,  Madhavi Chandra

IPC: G06F15/173 ,  H04L12/56

CPC classification number: H04L45/28 ,  H04L45/02 ,  H04L45/021 ,  H04L45/028 ,  H04L45/32

Abstract: An apparatus for communicating packets in a network environment is provided that includes a first network element that includes a first neighbor list, the first network element being coupled to a second network element and a third network element. The first network element is operable to receive a second neighbor list from the second network element and a third neighbor list from the third network element. The first network element is further operable to determine one or more overlaps provided by the second and third neighbor lists when compared to the first neighbor list, the first network element relaying an update that it receives based on the one or more overlaps.

Abstract translation: 提供了一种用于在网络环境中传送分组的装置，其包括包括第一邻居列表的第一网络元件，所述第一网络元件耦合到第二网络元件和第三网络元件。 第一网络元件可操作以从第二网络元件接收第二邻居列表，并从第三网络元件接收第三邻居列表。 当与第一邻居列表相比较时，第一网络元件还可操作以确定由第二和第三邻居列表提供的一个或多个重叠，第一网络元件基于一个或多个重叠中继其接收的更新。

公开(公告)号：US20050018667A1

公开(公告)日：2005-01-27

申请号：US10625994

申请日：2003-07-24

Applicant: Madhavi Chandra ,  David Cook ,  Alvaro Retana ,  Russell White ,  Yi Yang

Inventor： Madhavi Chandra ,  David Cook ,  Alvaro Retana ,  Russell White ,  Yi Yang

IPC: G06F20060101 ,  H04L12/56

CPC classification number: H04L45/02 ,  H04L45/26 ,  H04W40/248

Abstract: A method for communicating packets in a network environment is provided that includes receiving a packet at a network element and identifying a sequence number included in the packet that correlates to awareness information associated with one or more adjacent network elements. A table included in the network element may be updated in order to account for the awareness information included within the packet that has not been accounted for by the network element. In cases where the awareness information included in the packet has already been accounted for, the packet may be ignored.

Abstract translation: 提供了一种用于在网络环境中传送分组的方法，包括在网络元件处接收分组并且识别与包含在与一个或多个相邻网络元素相关联的识别信息相关联的分组中的序列号。 可以更新包括在网络元件中的表，以便考虑包含在网络元件尚未被考虑的分组内的识别信息。 在分组中包含的识别信息已经被考虑的情况下，分组可以被忽略。

公开(公告)号：USD477401S1

公开(公告)日：2003-07-15

申请号：US29127312

申请日：2000-08-03

Applicant: Ian T. Petherbridge ,  David Cook

Designer： Ian T. Petherbridge ,  David Cook

公开(公告)号：US06575165B1

公开(公告)日：2003-06-10

申请号：US09632142

申请日：2000-08-03

Applicant: David Cook ,  Raymond Odell ,  Ian T. Petherbridge ,  Pierre Legare ,  Robert P. Lapointe ,  Kenneth J. Krepel ,  David M. Blomberg ,  Derek S. Baker ,  James R. Betz ,  Thomas I. Insley

Inventor： David Cook ,  Raymond Odell ,  Ian T. Petherbridge ,  Pierre Legare ,  Robert P. Lapointe ,  Kenneth J. Krepel ,  David M. Blomberg ,  Derek S. Baker ,  James R. Betz ,  Thomas I. Insley

IPC: A62B1808

CPC classification number: A62B18/006 ,  A62B9/006 ,  A62B9/04

Abstract: The present invention relates to a fan-forced positive pressure breathing apparatus commonly known as a Powered Air Purifying Respirators (PAPR) system, and specifically concerns the connecting of the breathing components of such equipment. The invention is a method and apparatus for rapid engagement of PAPR breathing components (such as air supply lines and filter elements to a blower housing). The invention also provides for indicating and/or monitoring whether the relative components have been aligned and coupled in sealed engagement.

Abstract translation: 本发明涉及一种通常称为动力空气净化呼吸器（PAPR）系统的风扇强制正压呼吸装置，具体涉及这种设备的呼吸部件的连接。 本发明是用于将PAPR呼吸部件（例如空气供给管线和过滤元件）快速接合到鼓风机壳体的方法和装置。 本发明还提供了指示和/或监测相关部件是否已经对准并且以密封接合方式耦合。

公开(公告)号：US6143490A

公开(公告)日：2000-11-07

申请号：US476842

申请日：1995-06-07

Applicant: David Cook ,  Susan Wollowitz ,  Aileen Nerio

Inventor： David Cook ,  Susan Wollowitz ,  Aileen Nerio

IPC: C12Q1/00 ,  A61K31/47 ,  A61K31/473 ,  A61K35/16 ,  A61L2/00 ,  A61P31/12 ,  C07D219/12 ,  C07D219/14 ,  C07D493/04 ,  C12N1/20 ,  C12N5/06 ,  C12N5/08 ,  C12N7/04 ,  C12N7/06 ,  C12Q1/68 ,  A01N1/02

CPC classification number: C07D493/04 ,  A61L2/0088 ,  C07D219/12 ,  C12N7/00 ,  C12N2730/10163 ,  C12N2740/16063 ,  C12N2795/18163

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

公开(公告)号：US12270286B2

公开(公告)日：2025-04-08

申请号：US18436806

申请日：2024-02-08

Applicant: David Cook

Inventor： David Cook

IPC: E21B43/26 ,  G06F30/27 ,  G01V1/40

Abstract: An apparatus and method for fracking optimization, wherein the apparatus includes at least a processor, and a memory, wherein the memory containing instructions configuring the at least a processor to receive a reservoir datum from at least a sensing device, generate a production training data include a plurality of reservoir datums as input correlated to a plurality of optimal production parameters as output, train a fracking optimization machine-learning model using the production training data, determine an optimal production parameter as a function of the fracking optimization machine-learning model, and generating an optimal production plan as a function of the optimal production parameter.

公开(公告)号：US20250111225A1

公开(公告)日：2025-04-03

申请号：US18737091

申请日：2024-06-07

Applicant: David Cook

Inventor： David Cook

IPC: G06N3/08

Abstract: An apparatus and method for generating a compiled artificial intelligence (AI) model. The apparatus incudes a processor that is configured to receive data sets from user devices. The processor is further configured to convert the data sets using a machine-learning model into a cleansed data format and generate an accumulated model using the converted data sets as training data.

公开(公告)号：US12159091B2

公开(公告)日：2024-12-03

申请号：US18405465

申请日：2024-01-05

Applicant: David Cook

Inventor： David Cook

IPC: G06F30/28

Abstract: An apparatus for multi-stage fracking, wherein the apparatus includes a pump configured to pump a fracking fluid into a rock region comprises a plurality of rock zones, and a computing device communicatively connected to the pump, wherein the computing device includes at least a processor, and a memory communicatively connected to the at least a processor containing instructions configuring the at least a processor to receive reservoir data, determine an optimal fracking stimulation parameter as a function of the reservoir data, identify a fracking stage as a function of the optimal fracking stimulation parameter, and adjust a pump configuration of the pump as a function of the fracking stage.

公开(公告)号：US20240005145A1

公开(公告)日：2024-01-04

申请号：US17853143

申请日：2022-06-29

Applicant: David Cook

Inventor： David Cook

IPC: G06N3/08

CPC classification number: G06N3/08

Abstract: An apparatus and method for generating a compiled artificial intelligence (AI) model. The apparatus incudes a processor that is configured to receive data sets from user devices. The processor is further configured to convert the data sets using a machine-learning model into a cleansed data format and generate an accumulated model using the converted data sets as training data.