公开(公告)号：US06750490B2

公开(公告)日：2004-06-15

申请号：US10443839

申请日：2003-05-23

申请人： Vladimir Berezin

发明人： Vladimir Berezin

IPC分类号： H01L31062

CPC分类号： H01L31/103 ,  H01L27/148 ,  H01L31/101

摘要： A pinned photodiode is operated without a transfer gate. This is done by forming a pinned photodiode which has a selective connection to the substrate. When the connection is turned on, the photodiode is pinned to the substrate, and kept at a specified potential. When the connection is off, the photodiode is disconnected from the substrate and hence floats. In this way, the area above the photoreceptor can be used both for a reception area and for a charge transfer area.

摘要翻译： 被钉扎的光电二极管在没有传输门的情况下工作。 这通过形成具有与衬底的选择性连接的钉扎光电二极管来完成。 当连接打开时，光电二极管被固定在基板上，并保持在指定的电位。 当连接断开时，光电二极管与基板断开，因此浮动。 以这种方式，感光体上方的区域可以用于接收区域和电荷转移区域。

公开(公告)号：US06750485B2

公开(公告)日：2004-06-15

申请号：US10459595

申请日：2003-06-12

申请人： Vladimir Berezin ,  Alexander Krymski ,  Eric R. Fossum

发明人： Vladimir Berezin ,  Alexander Krymski ,  Eric R. Fossum

IPC分类号： H01L31062

CPC分类号： G01S7/487 ,  H01L27/14601 ,  H01L27/14609 ,  H01L27/14643

摘要： A lock in pinned photodiode photodetector includes a plurality of output ports which are sequentially enabled. Each time when the output port is enabled is considered to be a different bin of time. A specified pattern is sent, and the output bins are investigated to look for that pattern. The time when the pattern is received indicates the time of flight.

摘要翻译： 锁定光电二极管光电检测器的锁定器包括顺序启用的多个输出端口。 每当启用输出端口时，都被认为是不同的时间段。 发送指定的模式，并调查输出框以查找该模式。 接收到花样的时间表示飞行时间。

公开(公告)号：US06677873B2

公开(公告)日：2004-01-13

申请号：US10241419

申请日：2002-09-10

申请人： Vladimir Berezin

发明人： Vladimir Berezin

IPC分类号： H03M120

CPC分类号： H03M1/20 ,  H03M1/46

摘要： An analog to digital converter oversamples an image signal, and uses the oversampled information to obtain additional resolution. The analog to digital converter is included in an image sensor device having a photosensor array of photosensitive of pixels and a plurality of analog to digital converters. Each of the analog to digital converters is adapted to produce a digital output with a first specified bit resolution. An interpolator is adapted to receive an output thus produced from an analog to digital converter and produce a digital output with a second specific bit resolution.

摘要翻译： 模数转换器对图像信号进行过采样，并使用过采样信息获得额外的分辨率。 模数转换器包括在具有像素光敏元件和多个模数转换器的光电传感器阵列的图像传感器装置中。 每个模数转换器适于产生具有第一指定位分辨率的数字输出。 内插器适于接收由模数转换器产生的输出，并产生具有第二特定比特分辨率的数字输出。

公开(公告)号：US06677628B2

公开(公告)日：2004-01-13

申请号：US10278395

申请日：2002-10-22

申请人： Vladimir Berezin

发明人： Vladimir Berezin

IPC分类号： H01L31062

CPC分类号： H01L31/103 ,  H01L27/148 ,  H01L31/101

摘要： A pinned photodiode is operated without a transfer gate. This is done by forming a pinned photodiode which has a selective connection to the substrate. When the connection is turned on, the photodiode is pinned to the substrate, and kept at a specified potential. When the connection is off, the photodiode is disconnected from the substrate and hence floats. In this way, the area above the photoreceptor can be used both for a reception area and for a charge transfer area.

公开(公告)号：US06603513B1

公开(公告)日：2003-08-05

申请号：US09250623

申请日：1999-02-16

申请人： Vladimir Berezin

发明人： Vladimir Berezin

IPC分类号： H04N5335

CPC分类号： H04N5/3741

摘要： A digital imaging system, such as an active pixel sensor (APS) system, includes an array of sensors arranged into lines that form rows and columns. Each sensor in the array includes a photosensor that collects electric charge when exposed to light. Each sensor also includes a select circuit that generates an output signal indicating the amount of charge collected by the photosensor during a given time, and a reset circuit that clears collected charge from the sensor at a selected time. The APS system also includes a line decoder circuit that produces select and reset signals and delivers the signals to the select circuits over control lines. Each control line connects to two adjacent lines, e.g., rows or columns, of the array, delivering a select signal to the image sensors in one of the two lines and delivering a reset signal to the image sensors in the other line.

摘要翻译： 诸如有源像素传感器（APS）系统的数字成像系统包括布置成行和列的线的传感器阵列。 阵列中的每个传感器包括一个光电传感器，当暴露于光时会收集电荷。 每个传感器还包括选择电路，其产生指示在给定时间期间由光传感器收集的电荷量的输出信号，以及在选定时间清除传感器收集的电荷的复位电路。 APS系统还包括线路解码器电路，其产生选择和复位信号，并通过控制线路将信号传送到选择电路。 每个控制线连接到阵列的两个相邻的线，例如行或列，将选择信号传送到两条线之一中的图像传感器，并将复位信号传送到另一条线中的图像传感器。

公开(公告)号：US09359405B2

公开(公告)日：2016-06-07

申请号：US14003824

申请日：2012-03-14

申请人： Vladimir Berezin ,  Elisabeth Bock

发明人： Vladimir Berezin ,  Elisabeth Bock

IPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/54 ,  C07K14/545 ,  C07K7/06

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  Y02A50/411

摘要： The present invention discloses novel peptides derived from the IL-1 receptor antagonist protein (IL1 RA), capable of binding to the cell surface IL-1 receptor 1 (IL1 R1) and interfere with the binding of IL-1 to IL1 R1. This binding thus effectively antagonizes the inflammatory effects of IL-1, such as by reducing TNF-alpha secretion from macrophages. This is of potential use as an anti-inflammatory factor throughout the human body, including the central nervous system. The use of said peptides as anti-inflammatory agents for treatment of pathological conditions wherein IL-1 plays a prominent role, such as inflammatory conditions of the body and the central nervous system, is thus an aspect of the present invention.

摘要翻译： 本发明公开了能够结合细胞表面IL-1受体1（IL1R1）并干扰IL-1与IL1R1结合的来源于IL-1受体拮抗蛋白（IL1 RA）的新型肽。 这种结合因此有效地拮抗IL-1的炎症作用，例如通过减少巨噬细胞的TNF-α分泌。 这可以作为整个人体的抗炎因子，包括中枢神经系统。 因此，所述肽作为抗炎剂用于治疗其中IL-1起突出作用的病理状况（例如身体和中枢神经系统的炎性病症）的用途是本发明的一个方面。

公开(公告)号：USRE44482E1

公开(公告)日：2013-09-10

申请号：US13343843

申请日：2012-01-05

申请人： Vladimir Berezin ,  Alexander I. Krymski ,  Eric R. Fossum

发明人： Vladimir Berezin ,  Alexander I. Krymski ,  Eric R. Fossum

IPC分类号： H01L31/062 ,  H01L31/101

CPC分类号： G01S7/487 ,  H01L27/14601 ,  H01L27/14609 ,  H01L27/14643

摘要： A lock in pinned photodiode photodetector includes a plurality of output ports which are sequentially enabled. Each time when the output port is enabled is considered to be a different bin of time. A specified pattern is sent, and the output bins are investigated to look for that pattern. The time when the pattern is received indicates the time of flight A CMOS active pixel image sensor includes a plurality of pinned photodiode photodetectors that use a common output transistor. In one configuration, the charge from two or more pinned photodiodes may be binned together and applied to the gate of an output transistor.

摘要翻译： 锁定光电二极管光电检测器的锁定器包括顺序启用的多个输出端口。 每当启用输出端口时，都被认为是不同的时间段。 发送指定的模式，并调查输出框以查找该模式。 接收图案的时间表示飞行时间CMOS有源像素图像传感器包括使用公共输出晶体管的多个钉扎光电二极管光电探测器。 在一种配置中，来自两个或更多个被钉扎的光电二极管的电荷可以并置在一起并施加到输出晶体管的栅极。

公开(公告)号：US08462248B2

公开(公告)日：2013-06-11

申请号：US12965322

申请日：2010-12-10

申请人： Vladimir Berezin

发明人： Vladimir Berezin

IPC分类号： H04N5/335

CPC分类号： H04N5/378 ,  H04N5/35572 ,  H04N5/374

摘要： An active pixel sensor includes mixed analog and digital signal integration on the same substrate. The analog part of the array forms the active pixel sensor, and the digital part of the array does digital integration of the signal.

摘要翻译： 有源像素传感器包括在同一衬底上的混合模拟和数字信号集成。 阵列的模拟部分形成有源像素传感器，阵列的数字部分对信号进行数字积分。

公开(公告)号：US08071549B2

公开(公告)日：2011-12-06

申请号：US12435043

申请日：2009-05-04

申请人： Vladislav V Kiselyov ,  Galina Skladchikova ,  Vladimir Berezin ,  Elisabeth Bock

发明人： Vladislav V Kiselyov ,  Galina Skladchikova ,  Vladimir Berezin ,  Elisabeth Bock

IPC分类号： A61K38/00 ,  C07K14/78 ,  C07K14/705

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.

摘要翻译： 本发明涉及包含第三免疫球蛋白（Ig3）模块和/或第四免疫球蛋白（Ig4）模块和/或第五免疫球蛋白（Ig5）模块和/或第一纤连蛋白III（Fn3,1） 模块和/或能够与成纤维细胞生长因子（FGF）受体和/或腺苷 - 丝氨酸蛋白酶相互作用的神经细胞粘附分子（NCAM）的第二纤连蛋白III（Fn3,2）模块或其片段或其变体， 三磷酸盐（ATP）和/或L1，因此化合物能够诱导分化，调节增殖，刺激再生，神经元可塑性和/或细胞存活。 此外，本发明涉及包含所述化合物的药物组合物，制备药物组合物的方法和所述化合物的用途。

公开(公告)号：US08008259B2

公开(公告)日：2011-08-30

申请号：US12092919

申请日：2006-11-07

申请人： Elisabeth Bock ,  Vladimir Berezin

发明人： Elisabeth Bock ,  Vladimir Berezin

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/16

CPC分类号： C07K14/475

摘要： The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.

摘要翻译： 本发明涉及能够刺激与记忆和学习相关的神经元细胞分化，神经细胞存活和神经元可塑性的肽序列。 本发明的肽序列衍生自属于神经营养因子的蛋白质，例如NGF，NT3，NT4 / 5和BDNF。 本发明还涉及包含所述肽片段的药物组合物及其用于治疗疾病或病症的用途，其中刺激神经元细胞分化，神经元细胞存活，刺激与学习和记忆相关的神经可塑性的作用对治疗有益。