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51.发明授权Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids 失效用于检测生物流体中的甘草酸性脂多糖的方法
公开(公告)号：US5198339A
公开(公告)日：1993-03-30
申请号：US553072
申请日：1990-07-13
IPC分类号： G01N33/53 , G01N33/569 , G01N33/577 , G01N33/579
CPC分类号： G01N33/579 , G01N33/56916 , G01N33/577 , Y10S435/81 , Y10S435/879 , Y10S436/815 , Y10S436/821
摘要： The invention relates to a method of detecting gram-negative bacterial endotoxin using antibody capture combined with amoebocyte lysate chromogenic detection. The method is highly sensitive and rapid and may be used for detection of specific endotoxin. In a particular application, picogram levels of Haemophilus influenzae are detected in plasma taken from previously infected mammals.
摘要翻译： 本发明涉及使用抗体捕获与变形细胞裂解物显色检测结合来检测革兰氏阴性细菌内毒素的方法。 该方法灵敏度高，可快速检测特异性内毒素。 在特定应用中，从先前感染的哺乳动物的血浆中检测到流感嗜血杆菌的皮克水平。
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52.发明授权Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae 失效产生针对流感嗜血杆菌的单克隆抗体的杂交细胞系
公开(公告)号：US4455296A
公开(公告)日：1984-06-19
申请号：US345201
申请日：1982-02-02
IPC分类号： A61K38/00 , A61K39/00 , C07K14/285 , C07K16/12 , A61K39/40 , A61K39/395 , C12N5/00 , C12N15/00
CPC分类号： C07K16/1242 , C07K14/285 , A61K38/00 , A61K39/00 , Y10S424/804 , Y10S424/807 , Y10S530/864
摘要： Continuous hybrid cell lines for producing monoclonal antibodies directed against outer membrane antigens of Haemophilus influenzae type b have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with outer membrane antigens of Haemophilus influenzae type b with hybridoma cells. The resulting fused cells were cloned and characterized as to antibody specificity against antigenic determinants of outer membranes of Haemophilus influenzae type b. One hybrid produces a monoclonal antibody which is capable of conferring passive immunity on Hib infected hosts.
摘要翻译： 已经开发了用于产生针对流感嗜血杆菌b型的外膜抗原的针对抗体的单克隆抗体的连续杂交细胞系。 混合细胞系通过将引发了流感嗜血杆菌B型外膜抗原的分化淋巴细胞与杂交瘤细胞融合而建立。 将所得的融合细胞克隆并表征为针对b型流感嗜血杆菌外膜抗原决定簇的抗体特异性。 一种杂交产生能够在Hib感染的宿主上赋予被动免疫的单克隆抗体。
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