公开(公告)号：US08163713B2

公开(公告)日：2012-04-24

申请号：US12294800

申请日：2007-03-22

申请人： Mugio Nishizawa ,  Hiroshi Imagawa ,  Hirofumi Yamamoto

发明人： Mugio Nishizawa ,  Hiroshi Imagawa ,  Hirofumi Yamamoto

IPC分类号： A61K31/70 ,  C07H13/02

CPC分类号： C07H15/04 ,  C07H3/04

摘要： The object of the present invention is to provide a novel trehalose compound having a high affinity for an adenosine A3 receptor. The trehalose compound of the present invention is represented by General Formula (1): wherein X and X′ represent a hydrogen atom, and the like; Y and Y′ independently represent an oxygen atom, and the like; R1 and R2 independently represent a C1-C6 alkyl group; and R3 and R4 independently represent a C3-C6 alkyl group. The trehalose compound of the present invention has a remarkably high affinity for an adenosine A3 receptor.

摘要翻译： 本发明的目的是提供对腺苷A3受体具有高亲和力的新型海藻糖化合物。 本发明的海藻糖化合物由通式（1）表示：其中X和X'表示氢原子等; Y和Y'独立地表示氧原子等; R1和R2独立地表示C1-C6烷基; 并且R 3和R 4独立地表示C 3 -C 6烷基。 本发明的海藻糖化合物对腺苷A3受体具有非常高的亲和力。

公开(公告)号：US20090207055A1

公开(公告)日：2009-08-20

申请号：US12180803

申请日：2008-07-28

申请人： Randall E. Aull ,  Firdosh K. Bhesania ,  Michael William John McCracken ,  Hirofumi Yamamoto ,  Steven N. Bathiche ,  Timothy T. Brewer

发明人： Randall E. Aull ,  Firdosh K. Bhesania ,  Michael William John McCracken ,  Hirofumi Yamamoto ,  Steven N. Bathiche ,  Timothy T. Brewer

IPC分类号： H03M11/02

CPC分类号： G06F3/023 ,  G06F3/0219

摘要： A computer receives data from a keyboard having one or more keys which cause generation of keyboard data that quantitatively describe the relative force applied to those keys. The keyboard data are transmitted in an HID report containing identifiers for one or more keys that have been pressed and force data for each key. The force data may be a multi-bit value quantifying the key force, or a null indicator signaling that the key is not force-sensing. Keyboard data messages are then prepared which identify keys pressed, contain force data, and may indicate whether the force data updates previous force data. Force updates are only provided to application programs registering for key force data. In other aspects of the invention, key repeat messages are automatically generated for a key held pressed by a user. The key repeat messages are generated at a rate controlled by the amount of force applied to the key.

摘要翻译： 计算机从具有一个或多个键的键盘接收数据，这些键导致产生定量描述施加于这些键的相对力的键盘数据。 键盘数据在包含已被按下的一个或多个键的标识符的HID报告中发送，并强制每个键的数据。 力数据可以是量化键力的多位值，或者是指示键不是力感测的空指示符。 然后准备键盘数据消息，其识别按下的键，包含力数据，并且可以指示力数据是否更新先前的力数据。 强制更新仅提供给注册关键力数据的应用程序。 在本发明的其他方面，对于用户按下的键，自动生成键重复消息。 密钥重复消息以由施加到密钥的力的量控制的速率生成。

公开(公告)号：US06895589B2

公开(公告)日：2005-05-17

申请号：US09681782

申请日：2001-06-04

申请人： Gerardo Bermudez ,  Hirofumi Yamamoto ,  Jason A. Schroeder ,  Firdosh K. Bhesania ,  Jay Senior ,  Doron J. Holan

发明人： Gerardo Bermudez ,  Hirofumi Yamamoto ,  Jason A. Schroeder ,  Firdosh K. Bhesania ,  Jay Senior ,  Doron J. Holan

IPC分类号： G06F3/00 ,  G06F9/46 ,  G06F13/10

CPC分类号： G06F9/54

摘要： A manager component for managing input from legacy and non-legacy devices in a similar manner is disclosed. An inventive manager component receives input from both non-legacy input drivers for non-legacy input devices, and legacy input drivers for legacy input devices. The manager component provides the input to application programs that desirably have previously registered to receive input from one or more types of input devices. The application programs receive this input without directly communicating with the drivers.

摘要翻译： 公开了一种用于以类似方式管理来自传统设备和非传统设备的输入的管理器组件。 创新的管理器组件接收来自用于非传统输入设备的非传统输入驱动器的输入以及用于传统输入设备的传统输入驱动器。 管理器组件向期望已经注册以从一个或多个类型的输入设备接收输入的应用程序提供输入。 应用程序接收此输入，而不直接与驱动程序通信。

公开(公告)号：US6159961A

公开(公告)日：2000-12-12

申请号：US356684

申请日：1999-07-19

申请人： Kohji Kawabata ,  Hirofumi Yamamoto ,  Yoshiteru Eikyu ,  Shinya Okuda ,  Hisashi Takasugi

发明人： Kohji Kawabata ,  Hirofumi Yamamoto ,  Yoshiteru Eikyu ,  Shinya Okuda ,  Hisashi Takasugi

IPC分类号： C07D501/04 ,  A61K31/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/00 ,  A61P31/04 ,  C07D501/00 ,  C07D501/06 ,  C07D501/22 ,  C07D501/24 ,  C07D501/36 ,  C07D501/56 ,  C07D501/59 ,  A61L31/546

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is hydrogen or hydroxy protective group,R.sup.3 is carboxy or protected carboxy,R.sup.4 is hydrogen, lower alkenyl, acyloxy(lower)alkenyl, optionally substituted heterocyclic(lower)alkenyl, optionally substituted heterocyclic(lower)alkenylthio, optionally substituted heterocyclic(lower)alkylthio, or optionally substituted heterocyclic-thio(lower)alkylthio andR5 is halogen or lower alkyland pharmaceutically acceptable salts thereof, which is useful as a medicament for prophylactic and therapeutic treatment of infectious diseases.

摘要翻译： 下式的化合物：其中R1是氨基或被保护的氨基，R2是氢或羟基保护基，R3是羧基或保护的羧基，R4是氢，低级烯基，酰氧基（低级）烯基，任选取代的杂环（低级）烯基， 任选取代的杂环（低级）烯硫基，任选取代的杂环（低级）烷硫基，或任选取代的杂环硫代（低级）烷硫基，R 5为卤素或低级烷基及其可药用盐，其可用作预防和治疗性治疗药物 的传染病。

公开(公告)号：US5635491A

公开(公告)日：1997-06-03

申请号：US50216

申请日：1993-06-21

申请人： Junzo Seki ,  Hirofumi Yamamoto ,  Shuji Yamane ,  Yutaka Takahashi ,  Kouichi Ushimaru

发明人： Junzo Seki ,  Hirofumi Yamamoto ,  Shuji Yamane ,  Yutaka Takahashi ,  Kouichi Ushimaru

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K31/70 ,  C07N1/00

CPC分类号： A61K31/70 ,  A61K47/10 ,  A61K47/26 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/19

摘要： A lyophilized preparation which releases a fat emulsion, wherein the emulsion particle has a mean diameter of 10 to 100 nm, when redissolved prior to use. This preparation is produced by adding maltose in an arbitrary stage of the production of said emulsion prior to lyophilization.

摘要翻译： PCT No.PCT / JP91 / 01509 Sec。 371日期：1993年6月21日 102（e）日期1993年6月21日PCT 1991年11月5日PCT公布。 第WO92 / 07552号公报 日期1992年5月14日一种释放脂肪乳剂的冻干制剂，其中乳液颗粒在使用前再溶解时具有10至100nm的平均直径。 该制备方法是在冷冻干燥之前在所述乳液生产的任意阶段加入麦芽糖。

公开(公告)号：US5534502A

公开(公告)日：1996-07-09

申请号：US418861

申请日：1995-04-07

申请人： Junzo Seki ,  Hirofumi Yamamoto ,  Shuji Yamane ,  Yutaka Takahashi ,  Kouichi Ushimaru

发明人： Junzo Seki ,  Hirofumi Yamamoto ,  Shuji Yamane ,  Yutaka Takahashi ,  Kouichi Ushimaru

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K31/20 ,  A61K31/44 ,  A61K47/30 ,  A61K47/44

CPC分类号： A61K9/0019 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/26 ,  A61K9/1075 ,  A61K9/19 ,  Y10S514/937 ,  Y10S514/943

摘要： Stable homogeneous fatty emulsions containing amphotericin B are prepared. According to one embodiment, amphotericin B is decrystallized using an acid and ethanol and then homogeneously dispersed in a lipid, following which it is emulsified.According to a second embodiment, amphotericin B crystals are kneaded until their presence can no longer be confirmed and the decrystallized amphotericin B is thereafter uniformly dispersed in a lipid and, thereafter, emulsified.

摘要翻译： 制备含有两性霉素B的稳定的均匀脂肪乳剂。 根据一个实施方案，使用酸和乙醇将两性霉素B去结晶，然后均匀分散在脂质中，随后将其乳化。 根据第二实施方案，将两性霉素B晶体捏合直至其不能再确认​​，然后将去结晶的两性霉素B均匀地分散在脂质中，然后乳化。

公开(公告)号：US4928325A

公开(公告)日：1990-05-29

申请号：US350419

申请日：1989-05-11

申请人： Mitsuhiro Higuchi ,  Hirofumi Yamamoto

发明人： Mitsuhiro Higuchi ,  Hirofumi Yamamoto

IPC分类号： A47K13/20

CPC分类号： A47K13/20

摘要： A toilet seat structure capable of automatically feeding a seat covering paper onto the toilet seat has a paper feeding mechanism and a paper cutting mechanism operated by an electronic control unit. A specified length of paper appropriate for covering the toilet seat is automatically and accurately fed and positioned on the toilet seat. After use, the seat covering paper can automatically be cut off. For lavatories at public sites in particular, since the user can operate the apparatus to paper feed from a functional casing to provide a new seat covering paper on the toilet seat for each use, the user can be assured of a clean toilet seat. Also, since the seat covering paper is held immovably on the toilet seat, the use of the paper-covered toilet is made easier.

公开(公告)号：US11298370B2

公开(公告)日：2022-04-12

申请号：US16607681

申请日：2018-04-24

申请人： Hirofumi Yamamoto ,  Masaki Mori

发明人： Hirofumi Yamamoto ,  Masaki Mori

IPC分类号： A61K31/7105 ,  A61P43/00 ,  C12N15/113 ,  A61K47/51 ,  A61P1/00 ,  A61K9/00 ,  A61K9/14

摘要： The purpose of the present invention is to provide a therapeutic agent which is for inflammatory bowel disease and exhibits superior prophylactic or therapeutic effects on inflammatory bowel disease by using miR-29a and/or miR-29b. The prophylactic or therapeutic agent for inflammatory bowel disease comprises composite particles in which miR-29a and/or miR-29b is/are carried on carbonate apatite particles, and said agent is administered systemically.

公开(公告)号：US09295640B2

公开(公告)日：2016-03-29

申请号：US14010878

申请日：2013-08-27

申请人： Hirofumi Yamamoto ,  Toshihiro Akaike ,  Masaki Mori ,  Yuichiro Doki ,  Xin Wu ,  IJUNKAI

发明人： Hirofumi Yamamoto ,  Hiroyuki Nakanishi ,  Toshihiro Akaike ,  Masaki Mori ,  Yuichiro Doki ,  Xin Wu

IPC分类号： A61K48/00 ,  C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  A61K9/00 ,  A61K9/51

CPC分类号： A61K9/0019 ,  A61K9/5115 ,  C12N15/111 ,  C12N2320/32

摘要： A principal object of the present invention is to provide a pharmaceutical composition that can produce a high antitumor effect by efficiently delivering a drug with antitumor activity to tumor tissues with the aid of carbonate apatite nanoparticles. The present invention provides a pharmaceutical composition including carbonate apatite nanoparticles with an average particle size of at most 50 nm containing a drug with antitumor activity and a pharmacologically acceptable solvent in which the carbonate apatite nanoparticles containing the drug are dispersed.

摘要翻译： 本发明的主要目的是提供一种药物组合物，其可以借助于碳酸盐磷灰石纳米颗粒，有效地向肿瘤组织递送具有抗肿瘤活性的药物，从而产生高抗肿瘤效果。 本发明提供一种药物组合物，其包含平均粒径为50nm以下的碳酸磷灰石纳米粒子，其含有具有抗肿瘤活性的药物和药物可接受的溶剂，其中分散有所述药物的碳酸盐磷灰石纳米颗粒。

公开(公告)号：US08860189B2

公开(公告)日：2014-10-14

申请号：US13520357

申请日：2010-02-17

申请人： Yoshikazu Nishimura ,  Hirofumi Yamamoto ,  Takeyoshi Uchino

发明人： Yoshikazu Nishimura ,  Hirofumi Yamamoto ,  Takeyoshi Uchino

IPC分类号： H01L29/66 ,  H01L29/06 ,  H01L29/868

CPC分类号： H01L29/868 ,  H01L29/0615 ,  H01L29/0619 ,  H01L29/0638 ,  H01L29/0692 ,  H01L29/6609

摘要： Provided is a PIN diode that can suppress thermal destruction from occurring at the time of a reverse bias exceeding a breakdown voltage by current concentration on a curved part of an anode region. The PIN diode is configured to have: a semiconductor substrate 11 that includes an N+ semiconductor layer 1 and an N− semiconductor layer 2; a cathode electrode 18 that is formed on an outer surface of the N+ semiconductor layer 1; a main anode region 16, a separated anode region 15, and an anode connecting region that are formed by selectively diffusing P-type impurities from an outer surface of the N− semiconductor layer 2; and an anode electrode 17 that is formed on the main anode region 16.

摘要翻译： 提供一种PIN二极管，其可以抑制在阳极区域的弯曲部分上的电流集中在超过击穿电压的反向偏压时发生热破坏。 PIN二极管被配置为具有：包括N +半导体层1和N半导体层2的半导体衬底11; 形成在N +半导体层1的外表面上的阴极18; 通过从N半导体层2的外表面选择性地扩散P型杂质而形成的主阳极区域16，分隔阳极区域15和阳极连接区域; 以及形成在主阳极区域16上的阳极电极17。