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69 条记录 (耗时 0.039 秒)

    MULTIFUNCTIONAL CORE FOR MOLECULAR IMAGING AND TARGETED DELIVERY OF MACROMOLECULES AND DRUGS
    51.
    发明申请
    MULTIFUNCTIONAL CORE FOR MOLECULAR IMAGING AND TARGETED DELIVERY OF MACROMOLECULES AND DRUGS 审中-公开
    用于分子成像和大分子和药物靶向递送的多功能核心

    公开(公告)号：US20070128116A1

    公开(公告)日：2007-06-07

    申请号：US11460500

    申请日：2006-07-27

    申请人： Zheng Wang ,  Irene Kazhdan ,  Jian Gao ,  Zhiqiang Han ,  Robert Marciniak

    发明人： Zheng Wang ,  Irene Kazhdan ,  Jian Gao ,  Zhiqiang Han ,  Robert Marciniak

    IPC分类号： A61K49/00 ,  A61K48/00 ,  A61K31/409 ,  A61K31/555

    CPC分类号： A61K51/1018 ,  A61K31/409 ,  A61K31/555 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0056 ,  A61K51/088

    摘要： In the broadest sense an inventive conjugate includes a macrocyclic scaffold moiety incorporating at least one nitrogen atom. Through linkages to the ring, nitrogen atoms are bonded to at least one therapeutic species, or one cellular trafficking species, and preferably two or more types of trafficking species. The linkages between ring nitrogen atoms and agents are formed through N—C, N—S, N—O or N—N bonds. It is appreciated that more than one agent or agent species are coupled to a ring nitrogen atom through the inclusion of a branched carbon atom or secondary amine nitrogen within the intermediate between the agent and ring nitrogen atom. A disulfide bond intermediate between an agent and a linkage to the ring nitrogen is preferred in instances where intracellular release of the agent or trafficking species is desired. An optional metal ion is coordinated by the scaffolding moiety.

    摘要翻译： 在最广泛的意义上，本发明的缀合物包括并入至少一个氮原子的大环支架部分。 通过与环的连接，氮原子与至少一种治疗物种或一种细胞运输物种结合，优选结合两种或更多种类型的贩运物种。 通过N-C，N-S，N-O或N-N键形成环氮原子和试剂之间的键。 应当理解，通过在试剂和环氮原子之间的中间体中包含支链碳原子或仲胺氮，将多于一种试剂或试剂物质偶联到环氮原子。 在试剂或转运物种的细胞内释放是需要的情况下，优选在试剂与环氮键的中间的二硫键。 任选的金属离子由支架部分配位。

    7,2″-dehydrate puerarin and its salts, preparation method and use thereof
    52.
    发明授权
    7,2″-dehydrate puerarin and its salts, preparation method and use thereof 有权
    7,2“ - 脱水葛根素及其盐，其制备方法和用途

    公开(公告)号：US08436155B2

    公开(公告)日：2013-05-07

    申请号：US13177575

    申请日：2011-07-07

    申请人： Hongxiang Lou ,  Jian Gao ,  Xia Xue

    发明人： Hongxiang Lou ,  Jian Gao ,  Xia Xue

    IPC分类号： C07H15/00 ,  C07H17/00 ,  C07H17/02 ,  C07H15/04 ,  C07H1/00 ,  C07H3/00

    CPC分类号： C07D493/14

    摘要： A 7,2″-dehydrate puerarin represented by formula (I) and salt derivatives thereof. The compounds are prepared from puerarin by intramolecular mitsunobu reaction. They are capable of shortening arrhythmia duration and prolonging coagulation time. They can be prepared into oral formulations or injections for treatment of cardiovascular and cerebrovascular diseases including arrhythmia, coronary heart disease, angina pectoris, myocardial infarction, and cerebral infarction.

    摘要翻译： 由式（I）表示的7,2“ - 脱水葛根素及其盐衍生物。 该化合物由葛根素通过分子内mitsunobu反应制备。 它们能够缩短心律失常持续时间并延长凝血时间。 它们可以制备成口服制剂或注射用于治疗心血管和脑血管疾病，包括心律失常，冠心病，心绞痛，心肌梗死和脑梗死。

    AUTOMATIC CALIBRATION FOR DEVICE WITH CONTROLLED MOTION RANGE
    53.
    发明申请
    AUTOMATIC CALIBRATION FOR DEVICE WITH CONTROLLED MOTION RANGE 有权
    具有受控运动范围的设备的自动校准

    公开(公告)号：US20120203490A1

    公开(公告)日：2012-08-09

    申请号：US13184370

    申请日：2011-07-15

    申请人： Sohail Sayeh ,  George Asmerom ,  Sankaralingam Ramraj ,  Jian Gao ,  Gopinath Kuduvalli

    发明人： Sohail Sayeh ,  George Asmerom ,  Sankaralingam Ramraj ,  Jian Gao ,  Gopinath Kuduvalli

    IPC分类号： G06F19/00 ,  G21K1/04

    CPC分类号： G21K1/04 ,  A61N5/1045 ,  A61N5/1075

    摘要： An apparatus includes a portion that moves along a guided path and a displacement gauge that outputs readings based on the portion's position on the guided path. The apparatus additionally includes an intermediate limit switch that is activated in response to the portion being moved to an intermediate position on the guided path. The apparatus also includes a processing device configured to calibrate the apparatus based on a first reading corresponding to a first position on the guided path and a second reading corresponding to a second position on the guided path. The processing device verifies the calibration based on a third reading corresponding to the intermediate position.

    摘要翻译： 一种装置包括沿着导向路径移动的部分和基于导向路径上的该部分位置输出读数的位移计。 该装置还包括中间限位开关，其响应于被移动到被引导路径上的中间位置的部分被激活。 该装置还包括处理装置，其被配置为基于对应于被引导路径上的第一位置的第一读数和对应于被引导路径上的第二位置的第二读取来校准装置。 处理装置基于对应于中间位置的第三读数来验证校准。

    Dual Cation Dual Anion Coordination Complexes
    56.
    发明申请
    Dual Cation Dual Anion Coordination Complexes 有权
    双阳离子双阴离子配位络合物

    公开(公告)号：US20100184866A1

    公开(公告)日：2010-07-22

    申请号：US12651927

    申请日：2010-01-04

    申请人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

    发明人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

    IPC分类号： A61K31/09 ,  C07C43/30

    CPC分类号： A61K31/194 ,  C07C59/265

    摘要： Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.

    摘要翻译： 本文提供了下式的配位络合物：AxByCit2Fz.mH2O，其中A是选自元素周期表中某些IA或IIA金属离子的阳离子; B是选自某些IIA金属离子和某些二价d嵌段过渡金属离子的阳离子; A和B不同; “Cit”是三元柠檬酸阴离子; x与y的化学计量比等于或高于1.0但低于8.0; m为0-12; 并且z被选择使得保持电中性。 本文提供的化合物可用于治疗饮食缺乏症，骨质疏松症，骨质减少，骨质流失和骨质流失的风险，以及涉及需要给予各种离子的其它医学病症。 此外，这些化合物可用作牙科用途的氟化物源，并且用于氟化水系统。

    Multi-energy static security CT system and imaging method
    57.
    发明授权
    Multi-energy static security CT system and imaging method 有权

    公开(公告)号：US11789175B2

    公开(公告)日：2023-10-17

    申请号：US17302320

    申请日：2021-04-30

    申请人： Baolei Li ,  Yantao Hu ,  Yunxiang Li ,  Zhili Cui ,  Jian Gao ,  Jie Luo

    发明人： Baolei Li ,  Yantao Hu ,  Yunxiang Li ,  Zhili Cui ,  Jian Gao ,  Jie Luo

    IPC分类号： G01V5/00

    CPC分类号： G01V5/005

    摘要： A multi-energy static security CT system comprises at least one N-stage image chain structure (5) and a baggage conveying belt (4) provided at an inner side at the bottom of the N-stage image chain structure (5). The N-stage image chain structure (5) and the baggage conveying belt (4) are fixed at a pre-configured positions by means of a machine frame (8). The N-stage image chain structures (5) are sequentially arranged in a forward direction of a baggage channel, and adjacent N-stage image chain structures (5) are offset relative to each other. By exposing radiation sources in the N-stage image chain structure (5) at different times, the static security CT system generates an image having a higher temporal resolution and more energy spectrum levels than an image generated by a spiral CT system. Also provided is an imaging method implemented by means of the static security CT system.

    Scanning-type x-ray source and imaging system therefor
    58.
    发明授权
    Scanning-type x-ray source and imaging system therefor 有权

    公开(公告)号：US11569055B2

    公开(公告)日：2023-01-31

    申请号：US17137064

    申请日：2020-12-29

    申请人： Zhili Cui ,  Jian Gao ,  Jinhui Xing

    发明人： Zhili Cui ,  Jian Gao ,  Jinhui Xing

    IPC分类号： H01J35/30 ,  H01J35/04 ,  H01J35/18 ,  H01J35/08 ,  H01J35/14 ,  H01J35/12 ,  H01J35/06 ,  G01N23/046

    摘要： Provided are a scanning-type X-ray source and an imaging system therefor. The scanning-type X-ray source comprises a vacuum cavity (1), wherein a cathode (2) and a plurality of anode target structures (3) are arranged in the vacuum cavity (1); a gate electrode (4) is arranged in a position, close to the cathode (2), in the vacuum cavity (1); a focusing electrode (5) is arranged in a position, close to the gate electrode (4), in the vacuum cavity (1); and a deflection coil (6) is arranged in a position, close to the gate electrode (4), at the outer periphery of the vacuum cavity (1). The scanning-type X-ray source generates electron beams by using cathode (2), controls the powering-on/off of the electron beams by the gate electrode (4), and the deflection coil (6) controls the direction of motion of the electron beams, so as to complete the switching between multiple focuses.