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1.发明申请METHODS AND COMPOSITIONS TO INHIBIT EDEMA FACTOR AND ADENYLYL CYCLASE 审中-公开抑制EDEMA因子和ADENYLYL CYCLASE的方法和组合物公开(公告)号：US20120010233A1
公开(公告)日：2012-01-12
申请号：US13154923
申请日：2011-06-07
申请人： Catherine H. Schein , Scott R. Gilbertson , Johnny W. Peterson , Deliang Chen , Maria Esterlla-Jimenez , Mary A. Walter , Jian Gao
发明人： Catherine H. Schein , Scott R. Gilbertson , Johnny W. Peterson , Deliang Chen , Maria Esterlla-Jimenez , Mary A. Walter , Jian Gao
IPC分类号： A61K31/438 , A61K31/196 , A61P31/04 , C07C229/60 , C07C229/52 , A61K31/24 , A61K31/122 , C07D471/04
CPC分类号： A61K31/122 , A61K31/192 , A61K31/216 , A61K31/34 , A61K31/44 , A61K31/47 , Y02A50/406 , Y02A50/471 , Y02A50/473 , Y02A50/481 , A61K2300/00
摘要： Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3′,5′-adenosine monophosphate. Specific compositions of the invention are also novel.
摘要翻译： 描述了小分子及其衍生物用于治疗和/或预防肠液流失。 还公开了使用所述分子及其衍生物治疗和/或预防与增加3'，5'-腺苷单磷酸水平相关的病症的方法。 本发明的具体组合物也是新颖的。
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2.发明申请公开(公告)号：US20090093519A1
公开(公告)日：2009-04-09
申请号：US12139212
申请日：2008-06-13
申请人： Catherine H. Schein , Scott R. Gilbertson , Johnny W. Peterson , Deliang Chen , Maria Estrella-Jimenez , Mary A. Walter , Jian Gao
发明人： Catherine H. Schein , Scott R. Gilbertson , Johnny W. Peterson , Deliang Chen , Maria Estrella-Jimenez , Mary A. Walter , Jian Gao
IPC分类号： A61K31/192 , A61K31/47 , A61K31/44 , A61K31/34 , A61K31/122 , A61K31/216 , A61P1/00
CPC分类号： A61K31/122 , A61K31/192 , A61K31/216 , A61K31/34 , A61K31/44 , A61K31/47 , Y02A50/406 , Y02A50/471 , Y02A50/473 , Y02A50/481 , A61K2300/00
摘要： Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3′,5′-adenosine monophosphate. Specific compositions of the invention are also novel.
摘要翻译： 描述了小分子及其衍生物用于治疗和/或预防肠液流失。 还公开了使用所述分子及其衍生物治疗和/或预防与增加3'，5'-腺苷单磷酸水平相关的病症的方法。 本发明的具体组合物也是新颖的。
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3.发明授权公开(公告)号：US08003692B2
公开(公告)日：2011-08-23
申请号：US12139212
申请日：2008-06-13
申请人： Catherine H. Schein , Johnny W. Peterson , Scott R. Gilbertson , Deliang Chen , Maria Estrella-Jimenez , Mary A. Walter , Jian Gao
发明人： Catherine H. Schein , Johnny W. Peterson , Scott R. Gilbertson , Deliang Chen , Maria Estrella-Jimenez , Mary A. Walter , Jian Gao
IPC分类号： A61K31/195 , A61K31/192 , A61K31/381 , A61K31/343 , A61K31/403
CPC分类号： A61K31/122 , A61K31/192 , A61K31/216 , A61K31/34 , A61K31/44 , A61K31/47 , Y02A50/406 , Y02A50/471 , Y02A50/473 , Y02A50/481 , A61K2300/00
摘要： Fluorene-based molecules and their derivatives are described in compositions for the treatment of intestinal fluid loss.
摘要翻译： 在用于治疗肠液体流失的组合物中描述了基于芴的分子及其衍生物。
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4.发明授权
公开(公告)号：US5541289A
公开(公告)日：1996-07-30
申请号：US220245
申请日：1994-03-30
申请人： Scott R. Gilbertson
发明人： Scott R. Gilbertson
IPC分类号： B01J31/06 , B01J31/16 , B01J31/18 , B01J31/22 , C07C45/50 , C07F9/53 , C07K1/00 , B01J31/24 , C07F9/50 , C07K1/113 , C07K7/08
CPC分类号： C07K1/006 , B01J31/062 , B01J31/1658 , B01J31/189 , C07C45/505 , C07F9/5304 , B01J2231/321 , B01J2231/323 , B01J2231/44 , B01J2231/645 , B01J2531/0275 , B01J2531/70 , B01J2531/74 , B01J2531/821 , B01J2531/822 , B01J2531/828 , B01J2531/847 , B01J31/1805 , B01J31/1875
摘要： A method for incorporating novel phosphine containing amino acids into peptide sequences is provided. The resulting phosphine-containing peptides can be used to bind a transition metal between two phosphine moieties presented on an amino acid in a peptide. The resulting phosphine-containing peptide metal complex is useful as a stereoselective catalyst of a chemical reaction or as a means for delivering a metal selectively to a target tissue or organ for medical uses.
摘要翻译： 提供了将新的含有膦的氨基酸并入肽序列的方法。 所得到的含膦肽可用于结合存在于肽中的氨基酸上的两个膦部分之间的过渡金属。 所得的含膦肽多肽金属络合物可用作化学反应的立体选择性催化剂，或用作选择性地将靶金属或器官用于医疗用途的手段。
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5.发明申请Substrate peptide sequences for plague plasminogen activator and uses thereof 审中-公开用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US20120045474A1
公开(公告)日：2012-02-23
申请号：US13199407
申请日：2011-08-29
IPC分类号： A61K39/02 , A61K38/08 , A61K38/07 , A61K38/06 , A61P31/04 , C40B30/08 , C07C225/18 , C07C61/08 , C07C63/49 , C07D409/12 , C07D333/36 , C07K7/06 , C07K5/11 , C07K5/09 , A61P37/04 , C12Q1/37
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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公开(公告)号：US20190031672A1
公开(公告)日：2019-01-31
申请号：US16048216
申请日：2018-07-27
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , C07D487/06
摘要： The invention relates to the novel analogs of selective 5HT2CR agonist WAY163909, the preparation, and the use thereof.
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7.发明申请Substrate peptide sequences for plague plasminogen activator and uses thereof 有权用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US20090069248A1
公开(公告)日：2009-03-12
申请号：US11901978
申请日：2007-09-20
IPC分类号： C12Q1/37 , C07K7/06 , A61K38/02 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/08 , C07K5/10 , A61P31/04
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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公开(公告)号：US10544152B2
公开(公告)日：2020-01-28
申请号：US16048216
申请日：2018-07-27
IPC分类号： C07D243/10 , C07D243/14 , C07D487/22
摘要： The invention relates to the novel analogs of selective 5HT2CR agonist WAY163909, the preparation, and the use thereof.
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公开(公告)号：US09187523B2
公开(公告)日：2015-11-17
申请号：US13199407
申请日：2011-08-29
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
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10.发明授权Substrate peptide sequences for plague plasminogen activator and uses thereof 有权用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US08030447B2
公开(公告)日：2011-10-04
申请号：US11901978
申请日：2007-09-20
IPC分类号： C07K7/06
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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