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公开(公告)号：US08785393B2
公开(公告)日：2014-07-22
申请号：US13387064
申请日：2010-07-28
IPC分类号： A61K38/13
CPC分类号： A61K31/435 , A61K31/4355 , A61K31/4418
摘要： Described herein are ophthalmic pharmaceutical compositions, wherein the ophthalmic pharmaceutical compositions are in a form suitable for administration to an eye of a mammal. Ophthalmic pharmaceutical compositions disclosed herein include at least one DP2 receptor antagonist compound and are used to treat or prevent ophthalmic diseases or conditions.
摘要翻译： 本文描述的是眼用药物组合物，其中眼用药物组合物是适于给予哺乳动物眼睛的形式。 本文公开的眼科药物组合物包括至少一种DP2受体拮抗剂化合物，并用于治疗或预防眼科疾病或病症。
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![Cycloalkane[B]indole antagonists of prostaglandin D2 receptors](/abs-image/US/2013/08/06/US08501959B2/abs.jpg.150x150.jpg)
公开(公告)号：US08501959B2
公开(公告)日：2013-08-06
申请号：US12999133
申请日：2009-06-23
IPC分类号： C07D209/94 , A61K31/40
CPC分类号： C07D209/88 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/4866
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20120184496A1
公开(公告)日：2012-07-19
申请号：US13387064
申请日：2010-07-28
IPC分类号： A61K31/195 , A61K31/437 , A61K31/403 , A61K38/13 , A61K31/56 , A61P27/02 , A61P37/00 , A61P35/00 , A61P37/08 , A61P31/00 , A61P29/00 , A61P27/04 , A61P27/06 , A61P25/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P27/14 , A61K31/4418
CPC分类号： A61K31/435 , A61K31/4355 , A61K31/4418
摘要： Described herein are ophthalmic pharmaceutical compositions, wherein the ophthalmic pharmaceutical compositions are in a form suitable for administration to an eye of a mammal. Ophthalmic pharmaceutical compositions disclosed herein include at least one DP2 receptor antagonist compound and are used to treat or prevent ophthalmic diseases or conditions.
摘要翻译： 本文描述的是眼用药物组合物，其中眼用药物组合物是适于给予哺乳动物眼睛的形式。 本文公开的眼科药物组合物包括至少一种DP2受体拮抗剂化合物，并用于治疗或预防眼科疾病或病症。
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![CYCLOALKANE[B]AZAINDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2010/05/06/US20100113503A1/abs.jpg.150x150.jpg)
54.发明申请公开(公告)号：US20100113503A1
公开(公告)日：2010-05-06
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![Cycloalkane[B]azaindole antagonists of prostaglandin D2 receptors](/abs-image/US/2011/10/11/US08034826B2/abs.jpg.150x150.jpg)
55.发明授权公开(公告)号：US08034826B2
公开(公告)日：2011-10-11
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US07919621B2
公开(公告)日：2011-04-05
申请号：US11626222
申请日：2007-01-23
IPC分类号： C07D487/06 , A61K31/4745 , A61K31/4738
CPC分类号： C07D487/04 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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公开(公告)号：US09260416B2
公开(公告)日：2016-02-16
申请号：US13476607
申请日：2012-05-21
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
摘要翻译： 本文描述的是作为自分生素抑制剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及将这些抑制剂单独使用并与其它化合物组合用于治疗自体素受体依赖性或自体素介素介导的病症或疾病的方法。
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公开(公告)号：US20130029948A1
公开(公告)日：2013-01-31
申请号：US13476607
申请日：2012-05-21
IPC分类号： A61K31/4439 , C07D401/14 , A61P29/00 , A61K31/56 , A61P35/00 , A61P19/02 , A61P11/06 , A61P13/12 , A61P35/02 , A61P35/04 , A61P37/06 , A61P9/10 , C07D401/12 , A61P11/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
摘要翻译： 本文描述的是作为自分生素抑制剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及将这些抑制剂单独使用并与其它化合物组合用于治疗自体素受体依赖性或自体素介素介导的病症或疾病的方法。
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59.发明申请LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS OR DISEASES OF THE EYE 审中-公开用于治疗眼睛病情或疾病的赖氨酸磷酸受体拮抗剂公开(公告)号：US20130253019A1
公开(公告)日：2013-09-26
申请号：US13704276
申请日：2011-06-13
IPC分类号： A61K31/42 , A61K31/4245
CPC分类号： A61K31/42 , A61K31/4245 , A61K31/74
摘要： Described herein is the use of LPA1 antagonists in the treatment or prevention of diseases or conditions of the eye of a mammal. Also described are pharmaceutical compositions that include at least one LPA1 antagonist.
摘要翻译： 本文描述了LPA1拮抗剂在治疗或预防哺乳动物眼睛疾病或病症中的用途。 还描述了包含至少一种LPA1拮抗剂的药物组合物。
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公开(公告)号：US07795274B2
公开(公告)日：2010-09-14
申请号：US12131828
申请日：2008-06-02
IPC分类号： A61K31/4427 , C07D471/04 , A61P29/00
CPC分类号： C07D491/02 , C07D471/04 , C07D498/02
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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