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公开(公告)号：US20110112106A1
公开(公告)日：2011-05-12
申请号：US12987004
申请日：2011-01-07
申请人： John Howard HUTCHINSON , Thomas Jonathan SEIDERS , Brian Andrew STEARNS , Bowei WANG , Jill Melissa SCOTT , Yen Pham TRUONG
发明人： John Howard HUTCHINSON , Thomas Jonathan SEIDERS , Brian Andrew STEARNS , Bowei WANG , Jill Melissa SCOTT , Yen Pham TRUONG
IPC分类号： A61K31/4985 , C07D471/04 , A61K31/437 , A61P29/00 , A61P3/00 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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公开(公告)号：US07919621B2
公开(公告)日：2011-04-05
申请号：US11626222
申请日：2007-01-23
IPC分类号： C07D487/06 , A61K31/4745 , A61K31/4738
CPC分类号： C07D487/04 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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公开(公告)号：US20070173508A1
公开(公告)日：2007-07-26
申请号：US11626222
申请日：2007-01-23
申请人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Jill Melissa Scott , Yen Pham Truong
发明人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Jill Melissa Scott , Yen Pham Truong
IPC分类号： A61K31/498 , A61K31/4745 , C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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公开(公告)号：US20110021573A1
公开(公告)日：2011-01-27
申请号：US12918043
申请日：2009-02-25
申请人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/421 , A61K31/4166 , A61K31/4174 , C07D413/10 , C07D263/58 , C07D263/22 , C07D233/74 , C07D233/26 , A61P9/10 , A61P19/02 , A61P35/00 , A61P9/12 , A61P17/02 , A61P17/06 , A61P11/14 , A61P11/06
CPC分类号： C07D285/04 , C07D233/06 , C07D263/22 , C07D263/52
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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公开(公告)号：US08497381B2
公开(公告)日：2013-07-30
申请号：US12918043
申请日：2009-02-25
申请人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
IPC分类号： C07D277/04 , C07D263/04 , C07D233/02 , C07D231/04 , A61K31/425 , A61K31/42 , A61K31/415 , A61K31/40
CPC分类号： C07D285/04 , C07D233/06 , C07D263/22 , C07D263/52
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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6.发明授权Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors 失效环状二芳基醚化合物作为前列腺素D2受体的拮抗剂公开(公告)号：US08242145B2
公开(公告)日：2012-08-14
申请号：US12867476
申请日：2009-02-12
申请人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
发明人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
IPC分类号： A61K31/195 , A61K31/4418 , C07D213/64 , C07D229/00
CPC分类号： C07D233/32 , C07D207/38 , C07D263/22 , C07D263/52 , C07D413/12 , C07D417/12
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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