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1.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08362044B2
公开(公告)日：2013-01-29
申请号：US13272180
申请日：2011-10-12
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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2.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08067445B2
公开(公告)日：2011-11-29
申请号：US12865342
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195 , C07D213/64 , C07C229/00
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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3.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20110098352A1
公开(公告)日：2011-04-28
申请号：US12864859
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
IPC分类号： A61K31/195 , C07C229/34 , C07C271/10 , A61K31/27 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06
CPC分类号： C07C233/47 , C07C233/63 , C07C235/12 , C07C235/20 , C07C271/22 , C07C275/24 , C07C317/50 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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4.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 有权PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20110039852A1
公开(公告)日：2011-02-17
申请号：US12865342
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/5375 , C07C69/76 , C07C229/34 , C07D231/12 , C07D249/08 , C07D211/70 , C07D239/02 , C07D295/027 , A61K31/221 , A61K31/24 , A61K31/415 , A61K31/4196 , A61K31/44 , A61K31/505 , A61P11/00 , A61P37/00
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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5.发明授权Lysophosphatidic acid receptor antagonists and their use in the treatment fibrosis 有权溶血磷脂酸受体拮抗剂及其在治疗纤维化中的应用公开(公告)号：US09272990B2
公开(公告)日：2016-03-01
申请号：US13992053
申请日：2011-12-06
申请人： Thomas Jon Seiders , Bowei Wang , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas Jon Seiders , Bowei Wang , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
IPC分类号： C07D213/75 , C07D217/16 , C07D231/36 , C07D263/48 , C07D333/16 , C07D401/12 , C07D417/12 , C07D213/02 , C07C62/32 , C07C271/28 , C07C69/757 , C07C59/11 , C07D217/18 , C07D231/12 , C07D403/06
CPC分类号： C07C271/28 , C07C59/11 , C07C62/32 , C07C69/757 , C07C2601/02 , C07D213/02 , C07D213/75 , C07D217/16 , C07D217/18 , C07D231/12 , C07D231/36 , C07D263/48 , C07D333/16 , C07D401/12 , C07D403/06 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20110082181A1
公开(公告)日：2011-04-07
申请号：US12896080
申请日：2010-10-01
申请人： Thomas Jon SEIDERS , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas Jon SEIDERS , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/14 , C07D261/08 , A61P35/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P1/16 , A61P27/02 , A61P29/00
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US08785393B2
公开(公告)日：2014-07-22
申请号：US13387064
申请日：2010-07-28
IPC分类号： A61K38/13
CPC分类号： A61K31/435 , A61K31/4355 , A61K31/4418
摘要： Described herein are ophthalmic pharmaceutical compositions, wherein the ophthalmic pharmaceutical compositions are in a form suitable for administration to an eye of a mammal. Ophthalmic pharmaceutical compositions disclosed herein include at least one DP2 receptor antagonist compound and are used to treat or prevent ophthalmic diseases or conditions.
摘要翻译： 本文描述的是眼用药物组合物，其中眼用药物组合物是适于给予哺乳动物眼睛的形式。 本文公开的眼科药物组合物包括至少一种DP2受体拮抗剂化合物，并用于治疗或预防眼科疾病或病症。
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8.发明申请LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT FIBROSIS 有权赖氨酸磷酸受体拮抗剂及其在治疗性纤维化中的应用公开(公告)号：US20130253004A1
公开(公告)日：2013-09-26
申请号：US13992053
申请日：2011-12-06
申请人： Thomas Jon Seiders , Bowei Wang , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas Jon Seiders , Bowei Wang , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
IPC分类号： C07C271/28 , C07D263/48 , C07D333/16 , C07D417/12 , C07D231/12 , C07D217/18 , C07D401/12 , C07D403/06 , C07D213/02 , C07C59/11
CPC分类号： C07C271/28 , C07C59/11 , C07C62/32 , C07C69/757 , C07C2601/02 , C07D213/02 , C07D213/75 , C07D217/16 , C07D217/18 , C07D231/12 , C07D231/36 , C07D263/48 , C07D333/16 , C07D401/12 , C07D403/06 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20120184496A1
公开(公告)日：2012-07-19
申请号：US13387064
申请日：2010-07-28
IPC分类号： A61K31/195 , A61K31/437 , A61K31/403 , A61K38/13 , A61K31/56 , A61P27/02 , A61P37/00 , A61P35/00 , A61P37/08 , A61P31/00 , A61P29/00 , A61P27/04 , A61P27/06 , A61P25/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P27/14 , A61K31/4418
CPC分类号： A61K31/435 , A61K31/4355 , A61K31/4418
摘要： Described herein are ophthalmic pharmaceutical compositions, wherein the ophthalmic pharmaceutical compositions are in a form suitable for administration to an eye of a mammal. Ophthalmic pharmaceutical compositions disclosed herein include at least one DP2 receptor antagonist compound and are used to treat or prevent ophthalmic diseases or conditions.
摘要翻译： 本文描述的是眼用药物组合物，其中眼用药物组合物是适于给予哺乳动物眼睛的形式。 本文公开的眼科药物组合物包括至少一种DP2受体拮抗剂化合物，并用于治疗或预防眼科疾病或病症。
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公开(公告)号：US08217066B2
公开(公告)日：2012-07-10
申请号：US12896080
申请日：2010-10-01
申请人： Thomas Jon Seiders , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas Jon Seiders , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/14 , C07D261/08
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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