公开(公告)号：US07745198B2

公开(公告)日：2010-06-29

申请号：US10532412

申请日：2003-11-27

申请人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

发明人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

IPC分类号： C12N1/20 ,  A01N43/02

CPC分类号： C07D407/06 ,  A61K31/336 ,  C12P17/162

摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution.

摘要翻译： 本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。 作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的肌肉和氧的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

公开(公告)号：US07667052B2

公开(公告)日：2010-02-23

申请号：US11213962

申请日：2005-08-30

申请人： Yoshiharu Mizui ,  Takashi Sakai ,  Satoshi Yamamoto ,  Keisuke Komeda ,  Masanori Fujita ,  Akifumi Okuda ,  Kumiko Kishi ,  Jun Niijima ,  Mitsuo Nagai ,  Kiyoshi Okamoto ,  Masao Iwata ,  Yoshihiko Kotake ,  Toshimitsu Uenaka ,  Naoki Asai ,  Motoko Matsufuji ,  Tomohiro Sameshima ,  Naoto Kawamura ,  Kazuyuki Dobashi ,  Takashi Nakashima ,  Masashi Yoshida ,  Toshio Tsuchida ,  Susumu Takeda ,  Tomonari Yamada ,  Koji Norihisa ,  Takao Yamori

发明人： Yoshiharu Mizui ,  Takashi Sakai ,  Satoshi Yamamoto ,  Keisuke Komeda ,  Masanori Fujita ,  Akifumi Okuda ,  Kumiko Kishi ,  Jun Niijima ,  Mitsuo Nagai ,  Kiyoshi Okamoto ,  Masao Iwata ,  Yoshihiko Kotake ,  Toshimitsu Uenaka ,  Naoki Asai ,  Motoko Matsufuji ,  Tomohiro Sameshima ,  Naoto Kawamura ,  Kazuyuki Dobashi ,  Takashi Nakashima ,  Masashi Yoshida ,  Toshio Tsuchida ,  Susumu Takeda ,  Tomonari Yamada ,  Koji Norihisa ,  Takao Yamori

IPC分类号： C07D313/00 ,  C07D407/06 ,  A61K31/365

CPC分类号： C07D405/14 ,  A61K31/335 ,  A61K31/336 ,  A61K31/4025 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/455 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/74 ,  C07D313/00 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C12P17/02

摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.

摘要翻译： 本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。 即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。 梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

公开(公告)号：US20090251736A1

公开(公告)日：2009-10-08

申请号：US12412822

申请日：2009-03-27

申请人： Naoto Kawamura

发明人： Naoto Kawamura

IPC分类号： H04N1/40

CPC分类号： H04N1/4052

摘要： A quantizing unit quantizes a pixel of interest of an input image. An error detector calculates an error generated upon quantizing the pixel of interest. An error diffusion matrix diffuses the error to non-quantized pixels, which are separated by a predetermined distance from the pixel of interest and are located in a ring pattern, based on an error diffusion matrix.

摘要翻译： 量化单元量化输入图像的感兴趣像素。 误差检测器计算在量化感兴趣像素时产生的误差。 误差扩散矩阵将误差扩散到非量化像素，该非量化像素基于误差扩散矩阵而与感兴趣像素隔开预定距离并且位于环形图案中。

公开(公告)号：US20060256174A1

公开(公告)日：2006-11-16

申请号：US11493059

申请日：2006-07-25

申请人： Naoto Kawamura ,  Erik Ness ,  William Eaton ,  Charles Headrick

发明人： Naoto Kawamura ,  Erik Ness ,  William Eaton ,  Charles Headrick

IPC分类号： B41J2/175

CPC分类号： B41J2/17526

摘要： A printing apparatus includes one of a first cartridge or a second cartridge. The first cartridge has a first contact array including a plurality of contact areas. The second cartridge has a second contact array including a plurality of contact areas. The locations of the contact areas of the first contact array are different from locations of the contact areas of the second contact array. The printing apparatus further includes a carriage that interchangeably receives the first cartridge and the second cartridge. A controller identifies whether the first cartridge or the second cartridge is installed in the carriage.

摘要翻译： 打印装置包括第一盒或第二盒中的一个。 第一盒具有包括多个接触区域的第一接触阵列。 第二盒具有包括多个接触区域的第二接触阵列。 第一接触阵列的接触区域的位置不同于第二接触阵列的接触区域的位置。 打印设备还包括可互换地接收第一盒和第二盒的托架。 控制器识别第一盒或第二盒是否安装在托架中。

公开(公告)号：US07101029B2

公开(公告)日：2006-09-05

申请号：US10699147

申请日：2003-10-31

申请人： Naoto Kawamura ,  Erik D. Ness ,  William S. Eaton ,  Charles R. Headrick

发明人： Naoto Kawamura ,  Erik D. Ness ,  William S. Eaton ,  Charles R. Headrick

IPC分类号： B41J2/175

CPC分类号： B41J2/17526

摘要： A printing apparatus includes one of a first cartridge or a second cartridge. The first cartridge has a first contact array including a plurality of contact areas. The second cartridge has a second contact array including a plurality of contact areas. The locations of the contact areas of the first contact array are different from locations of the contact areas of the second contact array. The printing apparatus further includes a carriage that interchangeably receives the first cartridge and the second cartridge. A controller identifies whether the first cartridge or the second cartridge is installed in the carriage.

公开(公告)号：US20060141589A1

公开(公告)日：2006-06-29

申请号：US10532412

申请日：2003-11-27

申请人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

发明人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

IPC分类号： C12P17/02 ,  C12N1/21

CPC分类号： C07D407/06 ,  A61K31/336 ,  C12P17/162

摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured mycelia and oxygen, and then 11107D substance which is a target material is collected from the treating solution.

摘要翻译： 本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。 作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的菌丝体和氧气的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

公开(公告)号：US06783689B2

公开(公告)日：2004-08-31

申请号：US10145605

申请日：2002-05-10

申请人： Naoto Kawamura ,  David R Thomas ,  David J Waller ,  Timothy L. Weber

发明人： Naoto Kawamura ,  David R Thomas ,  David J Waller ,  Timothy L. Weber

IPC分类号： B41J204

CPC分类号： B41J2/164 ,  B41J2/14145 ,  B41J2/1603 ,  B41J2/1626 ,  B41J2/1631 ,  B41J2/1645 ,  B41J2002/14403 ,  Y10T29/49083 ,  Y10T29/49401

摘要： Pillars are formed in a fully integrated thermal inkjet printhead to prevent particles from entering into a nozzle chamber along an ink refill channel. The pillars are formed after a step of applying a thin film structure to a substrate. At one step, pits are etched through the thin film structure. At another step, material for an orifice layer is deposited into the pits. At another step, a firing chamber is etched into the orifice layer. At another step, a trench is etched into the backside of the wafer in the vicinity of the filled pits. The material filling each pit is not removed and remains in place to define the respective pillars. Two or more pillars are formed within the trench for each inkjet nozzle chamber. Alternatively pillars are formed by depositing material into the underside trench and performing photoimaging processes.

公开(公告)号：US06719398B1

公开(公告)日：2004-04-13

申请号：US09677837

申请日：2000-10-02

申请人： David McElfresh ,  Satya Prakash ,  Naoto Kawamura

发明人： David McElfresh ,  Satya Prakash ,  Naoto Kawamura

IPC分类号： B41J2015

CPC分类号： B41J2/04586 ,  B41J2/04526 ,  B41J2202/02

摘要： An inkjet printer includes a printhead having a plurality of ink orifices formed therein. During printing, ink drops are ejected through the ink orifices into a print zone between the printhead and a print medium with an intended ink drop trajectory toward the print medium. An air movement system directs an air stream to the print zone substantially parallel to the intended ink drop trajectory as the ink drops are ejected during printing so as to affect air currents acting on the ink drops during printing and prevent print defects caused by the air currents. The air stream, however, does not disrupt the intended trajectory of the ink drops during printing.

摘要翻译： 喷墨打印机包括其中形成有多个墨孔的打印头。 在打印期间，墨滴通过墨水孔喷射到打印头和打印介质之间的打印区域中，具有朝向打印介质的预期墨滴轨迹。 空气运动系统在印刷期间喷墨时基本平行于预期的墨滴轨迹将空气流引导到打印区域，以便影响在打印期间作用在墨滴上的气流，并防止由气流引起的打印缺陷 。 然而，空气流在打印期间不会破坏墨滴的预期轨迹。

公开(公告)号：US06692111B2

公开(公告)日：2004-02-17

申请号：US10081802

申请日：2002-02-22

申请人： Timothy E. Beerling ,  Marvin G. Wong ,  Wan Sin Ng ,  Juliana Arifin ,  Jiansan Sun ,  Arief Budiman Suriadi ,  Naoto Kawamura

发明人： Timothy E. Beerling ,  Marvin G. Wong ,  Wan Sin Ng ,  Juliana Arifin ,  Jiansan Sun ,  Arief Budiman Suriadi ,  Naoto Kawamura

IPC分类号： B41S205

CPC分类号： B41J2/1628 ,  B41J2/14024 ,  B41J2/14072 ,  B41J2/14129 ,  B41J2/1603 ,  B41J2/1623 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1643 ,  B41J2/1646

摘要： An electrical interconnect for an inkjet printhead comprising an ink-ejecting semiconductor die is described. The ink-ejecting die further comprises a substrate having an opposing upper surface, lower surface, and a thin film stack. The upper surface of the substrate is beveled on at least one edge such that a lower portion of the bevel is below an upper portion of the bevel. A conductive material trace is disposed on top of at least a portion of the upper surface and the thin film stack and on the bevel towards the lower portion of the bevel. An electrical conductor is coupled to the conductive material trace at a predetermined location below the upper portion of the bevel. In a preferred embodiment of the current invention, the conductive material trace is substantially below the surface of the printhead thereby creating a robust printhead having several advantages including but not limited to: (1) electrical interconnects that are solidified in an encapsulant and therefore protected from chemical etching of the ink and vibrational/physical forces generated by the printer, (2) minimized die to printing medium distance and (3) minimized ESD effects on the beveled die.

摘要翻译： 描述了一种用于包括喷墨半导体管芯的喷墨打印头的电互连。 喷墨模具还包括具有相对的上表面，下表面和薄膜叠层的基板。 基板的上表面在至少一个边缘上倾斜，使得斜面的下部在斜面的上部下方。 导电材料迹线设置在上表面和薄膜堆叠的至少一部分的顶部上，并且朝向斜面的下部的斜面上。 电导体在斜面的上部下方的预定位置处联接到导电材料迹线。 在本发明的优选实施例中，导电材料迹线基本上在打印头的表面下方，从而形成具有若干优点的坚固的打印头，包括但不限于：（1）在密封剂中固化的电互连， 油墨的化学蚀刻以及打印机产生的振动/物理力，（2）使模具与打印介质距离最小化，（3）最小化对斜面模具的ESD影响。

公开(公告)号：US06600828B1

公开(公告)日：2003-07-29

申请号：US09318819

申请日：1999-05-26

申请人： Naoto Kawamura

发明人： Naoto Kawamura

IPC分类号： G06K900

CPC分类号： G06T1/0035 ,  G06T2201/0051 ,  G06T2201/0061

摘要： When additional information is embedded into image data, both image quality and tolerance are improved. The image processing method includes the steps of: providing a plurality of pixels or a plurality of spatial-frequency components into which additional information is to be embedded; and changing the data value of the plurality of embedding pixels or spatial-frequency components in accordance with a value corresponding to the data value of the spatial-frequency components in order to embed the additional information.

摘要翻译： 当附加信息嵌入图像数据时，图像质量和容差都得到改善。 图像处理方法包括以下步骤：提供要嵌入附加信息的多个像素或多个空间频率分量; 并且根据与空间频率分量的数据值对应的值来改变多个嵌入像素的数据值或空间频率分量，以嵌入附加信息。