公开(公告)号：US20130204330A1

公开(公告)日：2013-08-08

申请号：US13808806

申请日：2011-07-15

申请人： M. Bret Schneider ,  Michael J. Partsch

发明人： M. Bret Schneider ,  Michael J. Partsch

IPC分类号： A61N5/00

CPC分类号： A61N2/002 ,  A61N1/06 ,  A61N1/406 ,  A61N2/02

摘要： Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.

摘要翻译： 本文描述的是调节一种或多种目标或组织区域，特别是一个或多个脑区域对治疗剂如药物，免疫剂，化合物，辐射等的敏感性的方法。特别地，方法和系统 本文描述的可以包括目标或非靶区域的磁刺激（包括经颅磁刺激），以调节一个或多个靶组织区域对治疗剂的敏感性。

公开(公告)号：US20130184511A1

公开(公告)日：2013-07-18

申请号：US13708076

申请日：2012-12-07

申请人： M. Bret Schneider ,  John R. Adler, JR.

发明人： M. Bret Schneider ,  John R. Adler, JR. ,  Doyle John Borchers, III

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/10 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1077

摘要： Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.

摘要翻译： 放射外科技术和系统通过将来自患者外部的辐射引导到患者大脑内的目标组织来治疗行为障碍（例如抑郁症，强迫症（Obcessive-compulsive Disorder，“OCD”），成瘾，食欲过盛等），通常不施加外科手术 外伤。 目标通常被包括在与行为障碍相关的神经回路中。 可以施用细胞亚致死剂量的辐射，并且可以通过调节靶和相关组织内的神经活性水平来减轻行为障碍，肥胖症等。 过敏和/或过度活跃的神经元组织可能被靶向，辐射向下调节过度活跃的神经元活动。 通过下调通常对相关神经电路施加负反馈或限制作用的目标的活动，可以增加电路的活动。

公开(公告)号：US08337382B2

公开(公告)日：2012-12-25

申请号：US12261347

申请日：2008-10-30

申请人： M. Bret Schneider ,  John R. Adler, Jr. ,  Doyle John Borchers, III ,  Michele Borchers, legal representative

发明人： M. Bret Schneider ,  John R. Adler, Jr. ,  Doyle John Borchers, III

IPC分类号： A61N5/10

CPC分类号： A61N5/1084 ,  A61N5/10 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1077

摘要： Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.

摘要翻译： 放射外科技术和系统通过将来自患者外部的辐射引导到患者大脑内的目标组织来治疗行为障碍（例如抑郁症，强迫症，强迫症，强奸症，痴呆等），通常不会引起手术创伤。 目标通常被包括在与行为障碍相关的神经回路中。 可以施用细胞亚致死剂量的辐射，并且可以通过调节靶和相关组织内的神经活性水平来减轻行为障碍，肥胖症等。 过敏和/或过度活跃的神经元组织可能被靶向，辐射向下调节过度活跃的神经元活动。 通过下调通常对相关神经电路施加负反馈或限制作用的目标的活动，可以增加电路的活动。

公开(公告)号：US08246649B2

公开(公告)日：2012-08-21

申请号：US12383094

申请日：2009-03-18

申请人： M. Bret Schneider ,  Rogelio Moncada

发明人： M. Bret Schneider ,  Rogelio Moncada

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2230/0093 ,  A61F2250/0001

摘要： An intravascular filter is constructed to electrostatically capture and retain particles of a targeted type (for example fat or methacrylate emboli), even if those particles are physically small enough to slip through the filter in the absence of electrostatic attraction. Specific types of targeted particles are thereby captured and retained with improved efficiency, while permitting free flow of non-targeted particles. This improvement permits intravascular filters to be constructed with low-resistance, widely spaced filter elements. Accordingly, more targeted particles are captured, less thrombosis occurs, less pressure drop occurs across the filter, and perfusion or blood collection in downstream areas is maintained.

摘要翻译： 构造血管内过滤器以静电捕获和保留靶向类型的颗粒（例如脂肪或甲基丙烯酸酯栓塞），即使这些颗粒物理上足够小以在没有静电吸引力的情况下穿过过滤器。 从而捕获并保持特定类型的目标颗粒，同时提供非目标颗粒的自由流动。 这种改进允许血管内过滤器由低电阻，宽间隔的过滤元件构成。 因此，捕获更有针对性的颗粒，发生较少的血栓形成，在过滤器上发生较少的压降，并维持下游区域的灌注或血液收集。

公开(公告)号：US20120016177A1

公开(公告)日：2012-01-19

申请号：US13240060

申请日：2011-09-22

申请人： David J. Mishelevich ,  M. Bret Schneider

发明人： David J. Mishelevich ,  M. Bret Schneider

IPC分类号： A61N2/02 ,  A61N2/00

CPC分类号： A61N2/004 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.

摘要翻译： 本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。 通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。 成像技术也可用于确定指定目标的位置。

公开(公告)号：US20110273251A1

公开(公告)日：2011-11-10

申请号：US13141100

申请日：2010-01-07

申请人： David J. Mishelevich ,  M. Bret Schneider

发明人： David J. Mishelevich ,  M. Bret Schneider

IPC分类号： H01F5/00

CPC分类号： A61N2/02 ,  A61N2/006

摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.

摘要翻译： 这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，该弯曲的磁性线圈环在顶点处连接，该顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45度和约70度，60度之间， 等等。）。 顶点区域成形为优化从TMS电磁体投射的磁场。 例如，顶点区域可以是水平的或垂直的。 在一些变型中，顶点区域通过重新排列形成两个线圈的导电绕组而形成，使得它们不再被布置在与弯曲的磁性线圈环的其它部分中相同的柱状结构中。 这些TMS电磁铁可能非常适合用于深脑经颅磁刺激。

公开(公告)号：US08052591B2

公开(公告)日：2011-11-08

申请号：US11429504

申请日：2006-05-05

申请人： David J. Mishelevich ,  M. Bret Schneider

发明人： David J. Mishelevich ,  M. Bret Schneider

IPC分类号： A61N2/00

CPC分类号： A61N2/004 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.

摘要翻译： 本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。 通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。 成像技术也可用于确定指定目标的位置。

公开(公告)号：US20110004450A1

公开(公告)日：2011-01-06

申请号：US12679960

申请日：2008-10-09

申请人： David J. Mishelevich ,  M. Bret Schneider

发明人： David J. Mishelevich ,  M. Bret Schneider

IPC分类号： G06F17/10 ,  G06F7/60

CPC分类号： A61N2/02 ,  A61N1/08 ,  A61N2/006

摘要： Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.

摘要翻译： 描述了经颅磁刺激（TMS）期间建模和显示磁场强度的方法和系统，特别是使用重叠磁场来建模和显示TMS以刺激深部脑区域的方法和系统。

公开(公告)号：US20090156884A1

公开(公告)日：2009-06-18

申请号：US12324227

申请日：2008-11-26

申请人： M. Bret Schneider ,  David J. Mishelevich

发明人： M. Bret Schneider ,  David J. Mishelevich

IPC分类号： A61N2/04 ,  A61N2/02

CPC分类号： A61N2/02

摘要： The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.

摘要翻译： 使用经颅磁刺激（TMS）治疗特定的神经和精神疾病需要使用特定的脉搏参数来靶向特定的神经解剖结构。 这里描述了定位和供电TMS电磁体以选择性地刺激深脑靶区域同时最小化对TMS电磁体和目标之间的非目标区域的影响的方法。 使用这些配置可以涉及物理，空间和/或时间求和的组合。 详细说明了实现时间求和的具体方法。

公开(公告)号：US06372973B1

公开(公告)日：2002-04-16

申请号：US09315384

申请日：1999-05-18

申请人： M. Bret Schneider

发明人： M. Bret Schneider

IPC分类号： G10H700

CPC分类号： G10H1/20 ,  G10H3/125 ,  G10H5/005 ,  G10H2210/066 ,  G10H2240/056

摘要： Musical instruments that generate notes according to sounds (e.g., vocal sounds) and manually selected scales are provided. Vocal sounds of the user are analyzed to select a note that will be generated in a scale selected by the user. The user can enter the scale or scale constraints by depressing a chord on a keyboard and the vocal sounds can be analyzed to determine which note on the selected scale is closest in pitch to the vocal sounds. Additionally, the generated notes can be augmented in other ways including having the onset and/or offset of the note generated adjusted to correspond to an identified rhythm in the ambient sounds.

摘要翻译： 提供根据声音（例如声乐声音）和手动选择的音阶产生音符的乐器。 分析用户的声音以选择将以用户选择的比例生成的音符。 用户可以通过按下键盘上的和弦来输入缩放或缩放约束，并且可以分析声音，以确定所选择的音阶上的音符与声音的间距最接近。 另外，生成的音符可以以其他方式增强，包括调整音符的开始和/或偏移以对应于环境声音中所识别的节奏。