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公开(公告)号：US09808651B2
公开(公告)日：2017-11-07
申请号：US13900131
申请日：2013-05-22
CPC分类号： A61N5/1031 , A61N5/0618 , A61N5/1039 , A61N5/1042 , A61N5/1049 , A61N5/1084
摘要： Medical systems, devices, and methods provide improved radiosurgical techniques for treatment of anxiety disorders (such as Post-Traumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), Panic Disorder, Social Phobia, Specific Phobia, and the like). Radiation can be directed from a radiation source outside the patient toward a target tissue deep within the patient's brain using a stereotactic radiosurgical platform, typically without having to impose the surgical trauma associated with accessing deep brain tissues. The target will often include at least a portion of the amygdala, with exemplary treatments being directed to targets that are limited to a sub-region of the amygdala. Rather than applying sufficient radiation to kill the neural tissue within the target, a cellularly sub-lethal dose of the radiation may be applied. Without imposing frank cell death throughout the target, the radiation can mitigate the anxiety disorder, obesity, or the like, often by modulating the level of neural activity within the target and in associated tissues.
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公开(公告)号：US09238150B2
公开(公告)日：2016-01-19
申请号：US12185624
申请日：2008-08-04
CPC分类号： A61N5/0622 , A61K36/05 , A61K38/16 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651 , C12N7/00 , C12N2710/10043 , C12N2710/16643 , G06F19/00
摘要： In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
摘要翻译： 在一个实例中，系统使用由光纤布置提供的细长结构，调制电路和光通路电刺激活动物体的靶细胞。 细长结构用于插入到动物中的狭窄通道中，使得细长结构的端部足够靠近靶细胞以向其施加刺激。 调制电路用于在细长结构处于窄通道中时调制靶细胞，其中调制电路适于通过细长结构递送病毒载体，用于在靶细胞中表达光响应蛋白。 光通路用于通过将光传递到靶细胞中的光响应蛋白来刺激靶细胞。
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公开(公告)号：US09132277B2
公开(公告)日：2015-09-15
申请号：US14247087
申请日：2014-04-07
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译： 这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，该弯曲的磁性线圈环在顶点处连接，该顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45度和约70度，60度之间， 等等。）。 顶点区域成形为优化从TMS电磁体投射的磁场。 例如，顶点区域可以是水平的或垂直的。 在一些变型中，顶点区域通过重新排列形成两个线圈的导电绕组而形成，使得它们不再被布置在与弯曲的磁性线圈环的其它部分中相同的柱状结构中。 这些TMS电磁铁可能非常适合用于深脑经颅磁刺激。
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公开(公告)号：US08956363B2
公开(公告)日：2015-02-17
申请号：US12997158
申请日：2009-06-17
申请人： M. Bret Schneider , Karl Deisseroth
发明人： M. Bret Schneider , Karl Deisseroth
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00005 , A61B2018/00107 , A61B2018/00273 , A61B2018/00708 , A61B2018/00791 , A61B2018/2266 , A61B2018/2272 , A61B2018/2288 , A61K38/1767 , A61K48/00 , A61N5/0616 , A61N5/062 , A61N5/0622 , A61N2005/0626 , A61N2005/063 , A61N2005/0643 , A61N2005/0644 , A61N2005/0652 , A61N2005/067
摘要： Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one such device, target cells are stimulated using an implantable device. The device includes a light source for producing light from electrical power. An optical transmission element is made from a material that is substantially transparent to the light from the light source. This transmission element substantially encases the light source at a proximal end. The transmission element delivers light from the light source to a distal end. The shape and size of the transmission element facilitates implanting of the element within a patient. A fixation portion physically couples to the optical transmission element and secures the device to the patient. A heat dissipation portion removes heat from the near optical transmission element and the light source and dissipates the removed heat through the fixation portion.
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公开(公告)号：US20140221725A1
公开(公告)日：2014-08-07
申请号：US14247087
申请日：2014-04-07
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译： 这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，该弯曲的磁性线圈环在顶点处连接，该顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45度和约70度，60度之间， 等等。）。 顶点区域成形为优化从TMS电磁体投射的磁场。 例如，顶点区域可以是水平的或垂直的。 在一些变型中，顶点区域通过重新排列形成两个线圈的导电绕组而形成，使得它们不再被布置在与弯曲的磁性线圈环的其它部分中相同的柱状结构中。 这些TMS电磁铁可能非常适合用于深脑经颅磁刺激。
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6.发明授权Radiosurgical neuromodulation devices, systems, and methods for treatment of behavioral disorders by external application of ionizing radiation 有权放射外科神经调节装置，系统和通过外部应用电离辐射治疗行为障碍的方法公开(公告)号：US08747292B2
公开(公告)日：2014-06-10
申请号：US13708076
申请日：2012-12-07
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/10 , A61N5/1039 , A61N5/1049 , A61N5/1077
摘要： Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.
摘要翻译： 放射外科技术和系统通过将来自患者外部的辐射引导到患者大脑内的目标组织来治疗行为障碍（例如抑郁症，强迫症（Obcessive-compulsive Disorder，“OCD”），成瘾，食欲过盛等），通常不施加外科手术 外伤。 目标通常被包括在与行为障碍相关的神经回路中。 可以施用细胞亚致死剂量的辐射，并且可以通过调节靶和相关组织内的神经活性水平来减轻行为障碍，肥胖症等。 过敏和/或过度活跃的神经元组织可能被靶向，辐射向下调节过度活跃的神经元活动。 通过下调通常对相关神经电路施加负反馈或限制作用的目标的活动，可以增加电路的活动。
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公开(公告)号：US08723628B2
公开(公告)日：2014-05-13
申请号：US13141100
申请日：2010-01-07
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译： 这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，该弯曲的磁性线圈环在顶点处连接，该顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45度和约70度，60度之间， 等等。）。 顶点区域成形为优化从TMS电磁体投射的磁场。 例如，顶点区域可以是水平的或垂直的。 在一些变型中，顶点区域通过重新排列形成两个线圈的导电绕组而形成，使得它们不再被布置在与弯曲的磁性线圈环的其它部分中相同的柱状结构中。 这些TMS电磁铁可能非常适合用于深脑经颅磁刺激。
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8.发明申请TRANSVERSE TRANSCRANIAL MAGNETIC STIMULATION COIL PLACEMENT FOR IMPROVED ANALGESIA 审中-公开用于改进的放射治疗的横断面磁刺激线圈放置公开(公告)号：US20130267763A1
公开(公告)日：2013-10-10
申请号：US13877428
申请日：2011-10-10
IPC分类号： A61N2/00
摘要： Described herein are methods for neuromodulating brain activity of one or more target brain regions, the methods using Transcranial Magnetic Stimulation (TMS) to produce robust analgesia. In particular, described herein are systems for arranging one or more (e.g., a plurality) of TMS electromagnets oriented in a transverse direction, perpendicular to the posterior-anterior axis of the head, and applying sufficient energy to neuromodulate the target deep brain region.
摘要翻译： 本文描述的是用于神经调节一个或多个靶脑区域的脑活动的方法，使用经颅磁刺激（TMS）产生强力镇痛的方法。 特别地，本文所描述的是用于布置一个或多个（例如，多个）TMS电磁体的系统，所述TMS电磁体在横向方向上定向，垂直于头部的前后轴线，并且施加足够的能量以对目标深部脑区域进行神经调制。
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公开(公告)号：US08523753B2
公开(公告)日：2013-09-03
申请号：US13586640
申请日：2012-08-15
IPC分类号： A61N2/02
CPC分类号： A61N2/02
摘要： The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.
摘要翻译： 使用经颅磁刺激（TMS）治疗特定的神经和精神疾病需要使用特定的脉搏参数来靶向特定的神经解剖结构。 这里描述了定位和供电TMS电磁体以选择性地刺激深脑靶区域同时最小化对TMS电磁体和目标之间的非目标区域的影响的方法。 使用这些配置可以涉及物理，空间和/或时间求和的组合。 详细说明了实现时间求和的具体方法。
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10.发明申请NEUROMODULATION OF DEEP-BRAIN TARGETS BY TRANSCRANIAL MAGNETIC STIMULATION ENHANCED BY TRANSCRANIAL DIRECT CURRENT STIMULATION 审中-公开通过转移性直接电流刺激增强的转移性磁刺激对神经细胞的神经调节作用公开(公告)号：US20130096363A1
公开(公告)日：2013-04-18
申请号：US13636022
申请日：2011-03-30
IPC分类号： A61N2/02
摘要： Described herein are methods, devices and systems for neuromodulation of deep brain targets using a combination of transcranial magnetic stimulation (TMS) and transcranial direct current (DC) stimulation to reduce or eliminate side-effects when modulating one or more deep brain targets. For example, transcranial magnetic stimulation of a deep brain target may be synchronized with modulation of more superficially located cortical brain regions using transcranial direct current stimulation to prevent seizures and other side effects. Systems configured to regulate (or synchronize) the application of transcranial magnetic stimulation of deep brain targets and transcranial direct current stimulation are also described.
摘要翻译： 本文描述的是使用经颅磁刺激（TMS）和经颅直流（DC）刺激的组合来神经调节深部脑靶标的方法，装置和系统，以在调节一个或多个深脑靶标时减少或消除副作用。 例如，通过使用经颅直流刺激来防止癫痫发作和其他副作用，深脑靶的经颅磁刺激可以与更多表面定位的皮层脑区域的调制同步。 还描述了被配置为调节（或同步）深脑靶和经颅直流刺激的经颅磁刺激的应用的系统。
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