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公开(公告)号：US06764649B2
公开(公告)日：2004-07-20
申请号：US09825067
申请日：2001-04-04
申请人： Kelly G. Ammann
发明人： Kelly G. Ammann
IPC分类号： G01N2113
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，预处理分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。
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52.发明授权Method and apparatus for performing multidirectional tibial tubercle transfers 有权用于执行多方向胫骨结节转移的方法和装置公开(公告)号：US07794466B2
公开(公告)日：2010-09-14
申请号：US11788318
申请日：2007-04-19
IPC分类号： A61B17/58
CPC分类号： A61B17/15 , A61B17/1764
摘要： A method and apparatus for performing a multidirectional tibial tubercle transfer, comprising: positioning a jig against the anterior portion of the tibia, the jig comprising first and second cutting guides which simultaneously converge towards one another as they extend distally down the tibia and posteriorly towards the tibia; cutting first and second saw cuts into the tibia; attaching an extender to the jig, wherein the extender comprises a third cutting guide which simultaneously converges towards the first cutting guide as the third cutting guide extends distally down the tibia and posteriorly towards the tibia; cutting a third saw cut into the tibia; freeing a first and second bone block from the tibia; freeing a second bone block from the tibia; and transferring the position of the first bone block relative to the tibia.
摘要翻译： 一种用于执行多向胫骨结节转移的方法和装置，包括：将夹具定位在胫骨的前部，所述夹具包括第一和第二切割引导件，所述第一和第二切割引导件当它们朝向胫骨向下延伸并向后朝向 胫骨 切割第一和第二次切割成胫骨; 将延伸器附接到所述夹具，其中所述延伸器包括第三切割引导件，所述第三切割引导件随着所述第三切割引导件朝所述胫骨向远侧延伸并向后朝向所述胫骨向后朝向所述第一切割引导件收敛; 将第三只锯切割成胫骨; 从胫骨释放第一和第二骨块; 从胫骨释放第二个骨块; 并且相对于胫骨转移第一骨块的位置。
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公开(公告)号：US20080212400A1
公开(公告)日：2008-09-04
申请号：US11927856
申请日：2007-10-30
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。
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54.发明申请Method and apparatus for performing multidirectional tibial tubercle transfers 有权用于执行多方向胫骨结节转移的方法和装置公开(公告)号：US20080154267A1
公开(公告)日：2008-06-26
申请号：US11788318
申请日：2007-04-19
CPC分类号： A61B17/15 , A61B17/1764
摘要： A method and apparatus for performing a multidirectional tibial tubercle transfer, comprising: positioning a jig against the anterior portion of the tibia, the jig comprising first and second cutting guides which simultaneously converge towards one another as they extend distally down the tibia and posteriorly towards the tibia; cutting first and second saw cuts into the tibia; attaching an extender to the jig, wherein the extender comprises a third cutting guide which simultaneously converges towards the first cutting guide as the third cutting guide extends distally down the tibia and posteriorly towards the tibia; cutting a third saw cut into the tibia; freeing a first and second bone block from the tibia; freeing a second bone block from the tibia; and transferring the position of the first bone block relative to the tibia.
摘要翻译： 一种用于执行多向胫骨结节转移的方法和装置，包括：将夹具定位在胫骨的前部，所述夹具包括第一和第二切割引导件，所述第一和第二切割引导件当它们朝向胫骨向下延伸并向后朝向 胫骨 切割第一和第二次切割成胫骨; 将延伸器附接到所述夹具，其中所述延伸器包括第三切割引导件，所述第三切割引导件随着所述第三切割引导件朝所述胫骨向远侧延伸并向后朝向所述胫骨向后朝向所述第一切割引导件收敛; 将第三只锯切割成胫骨; 从胫骨释放第一和第二骨块; 从胫骨释放第二个骨块; 并且相对于胫骨转移第一骨块的位置。
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公开(公告)号：US07135145B2
公开(公告)日：2006-11-14
申请号：US10145695
申请日：2002-05-16
IPC分类号： B01L3/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
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