公开(公告)号：US11899010B2

公开(公告)日：2024-02-13

申请号：US17664790

申请日：2022-05-24

申请人： Labrador Diagnostics LLC

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/151 ,  A61B5/150755 ,  B01J19/0046 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L9/543 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G16H10/40 ,  A61B10/007 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J2219/005 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L7/5255 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N2035/0097 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/475 ,  G01N2333/4737 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/9129 ,  G01N2333/91205 ,  G01N2800/26 ,  G01N2800/60 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20230405598A1

公开(公告)日：2023-12-21

申请号：US18037033

申请日：2021-11-04

申请人： Yokogawa Electric Corporation

发明人： Masahiro KUWATA

IPC分类号： B01L7/00

CPC分类号： B01L7/5255 ,  B01L2300/1805 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2200/02

摘要： A container (30) includes a plurality of accommodation portions (310) accommodating the sample, and a lid portion (320) closing the plurality of accommodation portions (310). The treatment apparatus (6) includes a container support portion (41) configured to support the plurality of accommodation portions (310), and a container fixing portion (42) configured to overlap the lid portion (320). The container fixing portion (42) is configured to sandwich the container (30) together with the container support portion (41). The container fixing portion (42) is provided in a manner of being able to be opened and closed with respect to the container support portion (41). A plurality of hole portions (411) are provided in the container support portion (41). A plurality of hook portions (420) inserted into the plurality of hole portions (411) and engaging with edge portions (411a) of the plurality of hole portions (411) are provided in the container fixing portion (42).

公开(公告)号：US20230383333A1

公开(公告)日：2023-11-30

申请号：US18230549

申请日：2023-08-04

申请人： Gen-Probe Incorporated

发明人： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC分类号： C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC分类号： C12Q1/6806 ,  G01N35/04 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N2035/0418 ,  G01N2035/0436 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046

摘要： A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.

公开(公告)号：US11761027B2

公开(公告)日：2023-09-19

申请号：US17877776

申请日：2022-07-29

申请人： Gen-Probe Incorporated

发明人： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC分类号： C12Q1/6806 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00

CPC分类号： C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

摘要： A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.

公开(公告)号：US11732289B2

公开(公告)日：2023-08-22

申请号：US17878580

申请日：2022-08-01

申请人： Gen-Probe Incorporated

发明人： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC分类号： C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

摘要： A receptacle distribution system includes a rotary distributor and a receptacle handoff device. The rotary distributor includes a motorized turntable with an upright wall, a distributor head for holding a receptacle, a hook configured to engage a receptacle for moving the receptacle into or out of the distributor head, and an a system for powered elevation of the distributor head. The receptacle handoff device is configured to transfer a receptacle from a first receptacle distributor to the rotary distributor and includes a receptacle yoke configured to hold a receptacle placed in the receptacle yoke with the first receptacle distributor, the receptacle yoke being rotatable between a first position to receive the receptacle and a second position to present the receptacle to the rotary distributor to enable the hook of the rotary distributor to pull the receptacle from the receptacle yoke and into the distributor head.

公开(公告)号：US11732288B2

公开(公告)日：2023-08-22

申请号：US17877832

申请日：2022-07-29

申请人： Gen-Probe Incorporated

发明人： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC分类号： C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

摘要： An assembly includes a bracket, a magnetic elution slot, and a reagent pack loading station. The elution slot receives a multiple receptacle device having multiple receptacles interconnected by a connecting rib defining shoulders along either side of the receptacle device. The elution slot includes opposed walls attached to the bracket below a top surface of the bracket with the opposed walls disposed on either side of a slot formed in the bracket. The downwardly facing shoulders of the receptacle device are supported on the top surface of the bracket on opposed sides of the slot, and one or more magnets are attached to or embedded in one or both walls. The reagent pack loading station holds a multi-well reagent pack such that the wells of the reagent pack are accessible by a pipettor, and the reagent pack holding station includes spaced apart hold down features extending above the top surface of the bracket.

公开(公告)号：US20190091694A1

公开(公告)日：2019-03-28

申请号：US16199261

申请日：2018-11-26

申请人： STAR ARRAY PTE LTD

发明人： Haiqing GONG ,  Yan WEN ,  Xudong ZENG

IPC分类号： B01L7/00 ,  B01L7/02 ,  C12Q1/686

CPC分类号： B01L7/5255 ,  B01F11/0005 ,  B01L3/5027 ,  B01L3/5082 ,  B01L7/02 ,  B01L7/52 ,  B01L9/00 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/06 ,  B01L2200/14 ,  B01L2300/0618 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2300/1894 ,  B01L2400/065 ,  C12Q1/6848 ,  C12Q1/686 ,  G01N35/00584 ,  G01N35/04 ,  G01N2035/00366 ,  G01N2035/00386 ,  G01N2035/00396 ,  G01N2035/0412

摘要： A method and an apparatus for thermal processing of nucleic acid in a thermal profile. The method employs at least a first bath and a second bath, the method further employing a reactor holder for holding reactor(s) accommodating reaction material containing the nucleic acid. The method includes maintaining bath mediums in the baths at two different temperatures; and alternately allowing the reactor(s) to be in the two baths in a plurality of thermal cycles to alternately attain a predetermined high target temperature THT, and a predetermined low target temperature TLT, wherein the bath medium in at least one of the baths is a high thermal conductivity powder.

公开(公告)号：US09821314B2

公开(公告)日：2017-11-21

申请号：US14429407

申请日：2013-09-18

申请人： CORNELL UNIVERSITY

发明人： David Erickson ,  Li Jiang ,  Matthew Mancuso

IPC分类号： C12Q1/68 ,  C12P19/34 ,  B01L7/00 ,  G01N35/00 ,  B01L3/00

CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L3/502715 ,  B01L7/5255 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1861 ,  C12Q1/686 ,  G01N2035/00158 ,  C12Q2565/629

摘要： Disclosed are methods and apparatus for solar-thermal microfluidic polymerase chain reaction. A device comprises a microfluidic chip including at least one PCR region, an energy absorption layer disposed adjacent to the microfluidic chip, a solar energy concentrator adapted to produce a plurality of temperature profiles on the microfluidic chip adapted to facilitate PCR, and a photomask disposed between the solar energy concentrator and the microfluidic chip.

公开(公告)号：US20170160218A1

公开(公告)日：2017-06-08

申请号：US15440806

申请日：2017-02-23

申请人： GEN-PROBE INCORPORATED

发明人： David OPALSKY ,  Norbert D. HAGEN ,  Rolf SILBERT ,  Sean S. CHIU ,  Haitao LI

IPC分类号： G01N25/04 ,  B01L7/00

CPC分类号： G01N25/04 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/028 ,  B01L2300/0627 ,  B01L2300/1827 ,  G01N21/6428 ,  G01N2021/6432 ,  G01N2021/6439

摘要： The present disclosure provides apparatus, systems, and methods for conducting rapid, accurate, and consistent heated amplifications and/or thermal melt analyses.

公开(公告)号：US09662653B2

公开(公告)日：2017-05-30

申请号：US14846931

申请日：2015-09-07

申请人： Frank Leo Spangler

发明人： Frank Leo Spangler

IPC分类号： C12M1/34 ,  B01L7/00

CPC分类号： B01L7/5255 ,  B01L2300/0809 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1883

摘要： In one embodiment, a thermal array comprises a first heating element and a second heating element, each surrounded by insulators which cover five sides of each heating element, held in position by a cooling block. Two thermal arrays are placed opposite each other creating a conduction channel wherein a sample vessel is transported between the heating elements and cooling block as the reaction requires. Due to the low energy consumption of each array, the thermal array system may function using standard D-cell batteries.