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公开(公告)号：US20090286849A1
公开(公告)日：2009-11-19
申请号：US12342025
申请日：2008-12-22
IPC分类号： A61K31/711 , C07H21/00 , C12Q1/68 , G01N33/68 , A61P17/06
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，该化合物可用于涉及IGF-1R的任何其它病症，包括炎症状况。
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公开(公告)号：US07563885B1
公开(公告)日：2009-07-21
申请号：US11135255
申请日：2005-05-23
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment of diseases and conditions associated with expression of Tudor-SN are provided.
摘要翻译： 提供化合物，组合物和方法用于调节Tudor-SN的表达。 组合物包含靶向编码Tudor-SN的核酸的寡核苷酸。 提供了使用这些化合物调节Tudor-SN表达和诊断和治疗与Tudor-SN表达相关的疾病和病症的方法。
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公开(公告)号：US20090082302A1
公开(公告)日：2009-03-26
申请号：US12274030
申请日：2008-11-19
申请人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
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公开(公告)号：US07507808B2
公开(公告)日：2009-03-24
申请号：US10319915
申请日：2002-12-12
申请人： Kenneth W. Dobie
发明人： Kenneth W. Dobie
CPC分类号： C07H21/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01003 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
摘要翻译： 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。
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公开(公告)号：US07468356B2
公开(公告)日：2008-12-23
申请号：US10545354
申请日：2004-02-11
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。
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公开(公告)号：US20080280845A1
公开(公告)日：2008-11-13
申请号：US11915309
申请日：2006-05-24
申请人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
发明人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
IPC分类号： A61K31/7125 , C07H21/04 , A61P3/10 , A61P3/04 , A61P3/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.
摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。
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公开(公告)号：US07399853B2
公开(公告)日：2008-07-15
申请号：US10832777
申请日：2004-04-27
申请人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
发明人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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公开(公告)号：US20080153766A1
公开(公告)日：2008-06-26
申请号：US11613144
申请日：2006-12-19
IPC分类号： A61K31/7088 , C07H21/04 , A61P43/00 , A61P3/10
CPC分类号： A61K45/06 , A61K38/00 , C12N9/0083 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/19001 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节硬脂酰辅酶A去饱和酶的表达。 组合物包含靶向编码硬脂酰辅酶A去饱和酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节硬脂酰辅酶A去饱和酶表达和治疗与硬脂酰辅酶A去饱和酶表达相关的疾病的方法。
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公开(公告)号：US07229976B2
公开(公告)日：2007-06-12
申请号：US10671074
申请日：2003-09-25
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US08642753B2
公开(公告)日：2014-02-04
申请号：US13566642
申请日：2012-08-03
申请人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
发明人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
IPC分类号： C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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