利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

92 条记录 (耗时 0.042 秒)

    Real-time delivery of medical test data to portable communications devices
    53.
    发明授权
    Real-time delivery of medical test data to portable communications devices 有权

    公开(公告)号：US11074998B1

    公开(公告)日：2021-07-27

    申请号：US10130402

    申请日：2000-11-14

    申请人： Lance A. Liotta ,  Tyson Liotta

    发明人： Lance A. Liotta ,  Tyson Liotta

    IPC分类号： G16H20/10 ,  G16H40/67 ,  G16H40/20 ,  G16H10/40 ,  G16H50/30

    摘要： The present invention relates to a system and method for real-time delivery of medical tests and related data from laboratories (12) or similar sources (18) to portable communication devices such as mobile phones (14), text-enabled pagers (14) and web-enabled personal digital assistance (PDA's) (14) and other WAP devices (14). The subject system enables physicians to access test results remotely as soon as they become available. Also, the system allows the physician to develop an electronic prescription and submit the electronic prescription to a pharmacy using the portable communications device (14).

    Combinatorial therapy for protein signaling diseases
    54.
    发明授权
    Combinatorial therapy for protein signaling diseases 有权
    组合治疗蛋白信号传导疾病

    公开(公告)号：US08835360B1

    公开(公告)日：2014-09-16

    申请号：US13455111

    申请日：2012-04-24

    申请人： Arpita I. Mehta ,  Lance A. Liotta ,  Emanuel F. Petricoin

    发明人： Arpita I. Mehta ,  Lance A. Liotta ,  Emanuel F. Petricoin

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5041

    摘要： A method for selecting combinations of drugs for treatment of diseases that arise from deranged signaling pathways is disclosed. The method involves measuring the activity states for signaling proteins in a diseased cell and determining whether the activity states are different from the activity states observed for a reference cell such as a normal cell. Based on the observed differences, combinations of two or more drugs are selected to reduce these differences. Treatment of a subject with the combinations restores the activity states of the signaling proteins of the deranged disease-associated signaling pathways toward the activity states observed in the reference cell. Since the diseased cell and the reference cell can both be obtained from the same subject, combinations of drugs that specifically target patient-specific signaling derangements is possible.

    摘要翻译： 公开了一种用于选择用于治疗由紊乱信号传导途径引起的疾病的药物组合的方法。 该方法包括测量患病细胞中的信号蛋白的活性状态，并确定活性状态是否与观察到的参考细胞例如正常细胞的活性状态不同。 基于观察到的差异，选择两种或更多种药物的组合以减少这些差异。 用组合治疗受试者恢复了与参考细胞中观察到的活动状态相关的紊乱疾病相关信号通路的信号蛋白的活性状态。 由于患病细胞和参照细胞都可以从相同的受试者获得，所以特别针对患者特异性信号紊乱的药物的组合是可能的。

    Tissue Preservation and Fixation Method
    55.
    发明申请
    Tissue Preservation and Fixation Method 有权
    组织保存和固定方法

    公开(公告)号：US20130345075A1

    公开(公告)日：2013-12-26

    申请号：US13836995

    申请日：2013-03-15

    申请人： Virginia A. Espina ,  Lance A. Liotta ,  David Geho

    发明人： Virginia A. Espina ,  Lance A. Liotta ,  David Geho

    IPC分类号： G01N1/30

    CPC分类号： G01N1/30 ,  A01N1/00

    摘要： This invention relates, e.g., to a composition that, at room temperature, when contacted with a sample comprising phosphoproteins, can fix and stabilize cellular phosphoproteins, preserve cellular morphology, and allow the sample to be frozen to generate a cryostat frozen section suitable for molecular analysis. The composition comprises (1) a fixative that stabilizes the proteins in the sample and that has a sufficient water content for a stabilizer and/or a permeability enhancing agent to be soluble therein; (2) a stabilizer, comprising (a) a kinase inhibitor and (b) a phosphatase inhibitor and, optionally, (c) a protease (e.g., proteinase) inhibitor; (3) a permeability enhancing agent; and (4) lactic acid. Methods and kits are described for preserving phosphoproteins, using such a composition. Also described are endogenous surrogate markers for monitoring protein degradation, including the loss of posttranslational modifications (such as phosphorylation), e.g. following removal of a cell or tissue from a subject; and exogenous molecular sentinels (e.g. phosphoproteins attached to magnetic nanoparticles) that allow one to evaluate the processing history of a cellular or tissue population sample.

    摘要翻译： 本发明涉及例如在室温下与包含磷蛋白的样品接触时可以固定和稳定细胞磷酸蛋白的组合物，保留细胞形态，并允许样品冷冻以产生适于分子的低温恒温器冷冻切片 分析。 组合物包含（1）稳定样品中蛋白质并且具有足够的水含量的固定剂，用于稳定剂和/或渗透性增强剂可溶于其中; （2）稳定剂，其包含（a）激酶抑制剂和（b）磷酸酶抑制剂和任选的（c）蛋白酶（例如蛋白酶）抑制剂; （3）渗透增强剂; 和（4）乳酸。 描述了使用这种组合物来保存磷蛋白的方法和试剂盒。 还描述了用于监测蛋白质降解的内源替代标记，包括翻译后修饰（例如磷酸化）的丧失，例如， 从受试者中除去细胞或组织; 和外源性分子前哨蛋白（例如连接到磁性纳米颗粒的磷酸蛋白），其允许评价细胞或组织群体样品的加工历史。

    Combinatorial therapy for protein signaling diseases
    57.
    发明授权
    Combinatorial therapy for protein signaling diseases 有权
    组合治疗蛋白信号传导疾病

    公开(公告)号：US08168568B1

    公开(公告)日：2012-05-01

    申请号：US12581019

    申请日：2009-10-16

    申请人： Arpita I. Mehta ,  Lance A. Liotta ,  Emanuel F. Petricoin

    发明人： Arpita I. Mehta ,  Lance A. Liotta ,  Emanuel F. Petricoin

    IPC分类号： C40B30/06

    CPC分类号： G01N33/5041

    摘要： A method for selecting combinations of drugs for treatment of diseases that arise from deranged signaling pathways is disclosed. The method involves measuring the activity states for signaling proteins in a diseased cell and determining whether the activity states are different from the activity states observed for a reference cell such as a normal cell. Based on the observed differences, combinations of two or more drugs are selected to reduce these differences. Treatment of a subject with the combinations restores the activity states of the signaling proteins of the deranged disease-associated signaling pathways toward the activity states observed in the reference cell. Since the diseased cell and the reference cell can both be obtained from the same subject, combinations of drugs that specifically target patient-specific signaling derangements is possible.

    摘要翻译： 公开了一种用于选择用于治疗由紊乱信号传导途径引起的疾病的药物组合的方法。 该方法包括测量患病细胞中的信号蛋白的活性状态，并确定活性状态是否与观察到的参考细胞例如正常细胞的活性状态不同。 基于观察到的差异，选择两种或更多种药物的组合以减少这些差异。 用组合治疗受试者恢复了与参考细胞中观察到的活动状态相关的紊乱疾病相关信号通路的信号蛋白的活性状态。 由于患病细胞和参照细胞都可以从相同的受试者获得，所以特别针对患者特异性信号紊乱的药物的组合是可能的。

    REAL-TIME DELIVERY OF MEDICAL TEST DATA TO PORTABLE COMMUNICATIONS DEVICES
    58.
    发明申请
    REAL-TIME DELIVERY OF MEDICAL TEST DATA TO PORTABLE COMMUNICATIONS DEVICES 审中-公开
    医疗测试数据实时传递给便携式通信设备

    公开(公告)号：US20110208534A1

    公开(公告)日：2011-08-25

    申请号：US13026346

    申请日：2011-02-14

    申请人： Lance A. Liotta ,  Tyson Liotta

    发明人： Lance A. Liotta ,  Tyson Liotta

    IPC分类号： G06Q50/00 ,  G06Q10/00

    CPC分类号： G06Q50/22 ,  G16H10/40 ,  G16H40/20

    摘要： The present invention relates to a system and method for real-time delivery of medical tests and related data from laboratories or similar sources to portable communication devices such as mobile phones, text-enabled pagers and web-enabled personal digital assistance (PDA's) and other WAP devices. The subject system enables physicians to access test results remotely as soon as they become available. Also, the system allows the physician to develop an electronic prescription and submit the electronic prescription to a pharmacy using the portable communications device.

    摘要翻译： 本发明涉及一种用于将实验室或类似来源的医学测试和相关数据实时传递到诸如移动电话，支持文本的寻呼机和具有网络的个人数字助理（PDA）等便携式通信设备的系统和方法。 WAP设备。 主题系统使医师能够在可用时立即远程访问测试结果。 此外，该系统允许医生开发电子处方，并使用便携式通信设备将电子处方提交给药店。