公开(公告)号：US07925327B2

公开(公告)日：2011-04-12

申请号：US10536843

申请日：2003-11-27

申请人： Juergen Weese

发明人： Juergen Weese

IPC分类号： A61B5/05

CPC分类号： A61B8/12 ,  A61B5/0066 ,  G06T19/00 ,  G06T2210/41

摘要： The invention relates to the assistance of the navigation of a catheter (1) in a vessel (2). A sequence of cross-sectional images of the portion of the vessel that is of interest is first obtained with the help of an intravascular ultrasound (IVUS) probe (3) and stored as a roadmap of the vessel. A cross-sectional image (10) that is obtained at the current position of the IVUS probe (3) can then be sorted to the position on the roadmap that is the best fit. A model (3′) of the probe, and a model (11′) of the instrument (a stent (11), for example) coupled to the probe, can be shown on a display (6) at the corresponding position on the roadmap.

摘要翻译： 本发明涉及导管（1）在血管（2）中导航的辅助。 首先通过血管内超声（IVUS）探针（3）的帮助首先获得感兴趣的血管部分的横截面图像序列，并存储为血管的路线图。 在IVUS探头（3）的当前位置处获得的横截面图像（10）可以被分类到路线图上最适合的位置。 耦合到探针的探针的模型（3'）和与仪器（例如支架）相连的模型（11'）可以在显示器（6）上显示在 路线图

公开(公告)号：US07738626B2

公开(公告)日：2010-06-15

申请号：US11815113

申请日：2006-01-31

申请人： Juergen Weese ,  Alexandra Groth ,  Joerg Bredno

发明人： Juergen Weese ,  Alexandra Groth ,  Joerg Bredno

IPC分类号： A61B6/02

CPC分类号： G06T11/003 ,  A61B6/481 ,  A61B6/504 ,  G06T7/0012 ,  G06T2207/10112 ,  G06T2207/10116 ,  G06T2207/30104 ,  G06T2211/404

摘要： The invention relates to a method and a system for the simultaneous reconstruction of the three-dimensional vessel geometry and the flow characteristics in a vessel system. According to one realization of the method, vessel segments (41) of a parametric models are fitted to differently oriented X-ray projections (P1, Pk, PN) of the vessel system that are generated during the passage of a bolus of contrast agent, wherein the fitting takes the imaged contrast agent dynamics and physiological a priori knowledge into account. In an alternative embodiment, the vessel geometry is reconstructed progressively along each vessel, wherein a new segment of a vessel is added based on the continuity of the vessel direction, vessel radius and reconstructed contrast agent dynamics.

摘要翻译： 本发明涉及用于同时重建血管系统中三维血管几何形状和流动特征的方法和系统。 根据该方法的一个实现，参数模型的血管段（41）被装配到在大量造影剂通过期间产生的血管系统的不同取向的X射线投影（P1，Pk，PN） 其中拟合将考虑了成像的造影剂动力学和生理学先验知识。 在替代实施例中，血管几何沿着每个血管逐渐重建，其中基于血管方向，血管半径和重建的造影剂动力学的连续性，添加血管的新部分。

公开(公告)号：US20080316226A1

公开(公告)日：2008-12-25

申请号：US12093762

申请日：2006-11-16

申请人： Martin Weibrecht ,  Olivier Ecabert ,  Juergen Weese ,  Gundolf Kiefer

发明人： Martin Weibrecht ,  Olivier Ecabert ,  Juergen Weese ,  Gundolf Kiefer

IPC分类号： G06T3/40 ,  G06T15/10

CPC分类号： G06T15/10

摘要： A method allowing display of time-varying merged high resolution and low resolution image data with a smooth frame rate. In one embodiment the high resolution data is structural image data and the low resolution image data is functional image data. The functional image data is gathered (20) into groups and each group is rendered and merged (24) together. The merged images produced are then stored (28) in a First In First Out (FIFO) buffer for display. While the merged images are displayed the next set of functional image data is merged and rendered and supplied to the FIFO buffer, allowing a smooth frame rate to be achieved. A computer program and a medical imaging apparatus using the method are also disclosed.

摘要翻译： 允许以平滑的帧速率显示时变合并的高分辨率和低分辨率图像数据的方法。 在一个实施例中，高分辨率数据是结构图像数据，低分辨率图像数据是功能图像数据。 将功能图像数据（20）收集到组中，并且将每个组渲染并合并（24）在一起。 然后将所生成的合并图像（28）存储在先进先出（FIFO）缓冲器中用于显示。 当显示合并的图像时，下一组功能图像数据被合并并呈现并提供给FIFO缓冲器，从而允许实现平滑的帧速率。 还公开了一种使用该方法的计算机程序和医学成像设备。

公开(公告)号：US20080194940A1

公开(公告)日：2008-08-14

申请号：US11815878

申请日：2006-02-13

申请人： Alexandra Groth ,  Juergen Weese ,  Joerg Bredno

发明人： Alexandra Groth ,  Juergen Weese ,  Joerg Bredno

IPC分类号： A61B5/00

CPC分类号： A61B6/507 ,  A61B5/4839 ,  A61B5/489 ,  A61B6/481 ,  A61B6/504 ,  A61M2005/14292 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/70 ,  G06T2207/20012 ,  G06T2207/30101

摘要： The present invention relates to an apparatus for determining an injection point for targeted drug delivery into a patient's body by injection of the drug into a vessel feeding a target area including a target. To provide the interventionalist with an objective and quantitative assessment of potential drug injection points instead of letting him rely on his subjective impression from the visual inspection of DSA sequences, an apparatus is proposed comprising: identification means (41) for identification of a vessel tree topology of vessels feeding said target area, flow determination means (42) for determining the percentage of drug material delivered to said target after injection into different potential injection points in said vessel tree, selection means (43) for selecting as optimal injection point the potential injection point resulting in the highest percentage of drug delivery to said target.

摘要翻译： 本发明涉及一种用于通过将药物注射到进食包括靶标的靶区域的血管中来确定靶向药物输送到患者体内的注射点的装置。 为了向介入者提供对潜在药物注射点的客观和定量评估，而不是让他依赖于他对DSA序列的视觉检查的主观印象，所以提出了一种装置，用于识别血管树形拓扑结构 供给所述目标区域的容器的流量确定装置（42），用于确定在注射到所述容器树中的不同潜在注入点之后输送到所述目标物的药物的百分比的选择装置（43），用于选择最佳注射点的潜在注射 指出，所述目标的药物分配比例最高。

公开(公告)号：US20070299639A1

公开(公告)日：2007-12-27

申请号：US11573795

申请日：2005-07-27

申请人： Juergen Weese ,  Gundolf Kiefer ,  Marc Busch ,  Helko Lehmann

发明人： Juergen Weese ,  Gundolf Kiefer ,  Marc Busch ,  Helko Lehmann

IPC分类号： G06F7/60

CPC分类号： G06T15/40 ,  G06T15/06

摘要： The present invention relates to direct volume rendering based on a light model applied to a 3D array of information data samples. Gradients are first estimated for the individuals samples, and a simple shading is done on the samples with low gradient, i.e. homogenous areas.

摘要翻译： 本发明涉及基于应用于信息数据样本的3D阵列的光模型的直接体绘制。 首先对个体样本估计渐变，并且对具有低梯度（即均匀区域）的样品进行简单的阴影。

公开(公告)号：US07043290B2

公开(公告)日：2006-05-09

申请号：US10235430

申请日：2002-09-05

申请人： Stewart Young ,  Vladimir Pekar ,  Juergen Weese

发明人： Stewart Young ,  Vladimir Pekar ,  Juergen Weese

IPC分类号： A61B5/05

CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30101 ,  G06T2210/41

摘要： An object, such as an example blood vessel, in a two or three dimensional image data set is segmented. An adaptable model, such as an example cylinder model, is defined around a starting point in the example blood vessel and is adapted or fit to the blood vessel. A plurality of candidate next active points are defined around the starting point and the adaptable model is defined around each candidate point. The models around the candidate points are adapted to the blood vessel. Based on results of the fitted models, a next active point is selected. In this manner, the blood vessel is segmented by adapting a series of cylinder models to an inner surface of the blood vessel.

摘要翻译： 在二维或三维图像数据集中的对象，例如血管，被分割。 围绕示例性血管的起始点定义适应性模型，例如示例性圆筒模型，并适于或适合于血管。 围绕起始点定义多个候选下一活动点，并且围绕每个候选点定义适应性模型。 候选点周围的模型适用于血管。 根据拟合模型的结果，选择下一个活动点。 以这种方式，通过使一系列圆柱模型适应于血管的内表面来分割血管。

公开(公告)号：US07010164B2

公开(公告)日：2006-03-07

申请号：US10091049

申请日：2002-03-05

申请人： Juergen Weese ,  Vladimir Pekar ,  Michael Kaus

发明人： Juergen Weese ,  Vladimir Pekar ,  Michael Kaus

IPC分类号： G06K9/34

CPC分类号： G06T7/0012 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/30012

摘要： A method of segmenting a selected region from a multi-dimensional dataset, which method comprises the steps of setting up a shape model representing the general outline of the selected region and setting up an adaptive mesh. The adaptive mesh represents an approximate contour of the selected region. The adaptive mesh is initialized on the basis of the shape model. Furthermore, the adaptive mesh is deformed in dependence on the shape model and on feature information of the selected region.

公开(公告)号：US06950542B2

公开(公告)日：2005-09-27

申请号：US09962386

申请日：2001-09-25

申请人： Peter Roesch ,  Juergen Weese

发明人： Peter Roesch ,  Juergen Weese

IPC分类号： A61B6/03 ,  A61B5/055 ,  G06K9/64 ,  G06T1/00 ,  G06T17/40 ,  G06K9/00

CPC分类号： G06K9/6206

摘要： The invention relates to a method of computing the transformation which transforms two different images (10, 10′) of an object one into the other while describing the motion or deformation of the object. In accordance with the method first the local transformation parameters are computed for sub-regions (1, 2, 3, 4, 5). By choosing the sub-regions so as to be sufficiently small, a rigid transformation can be used for this purpose. Starting from at least one first predetermined sub-region (1), the local transformation parameters of the neighboring sub-regions (2, 3, 4, 5) are successively computed, the starting values on which each computation is based being the already determined local transformation parameters of neighboring sub-regions. Using the local transformation parameters thus determined for sub-regions, the overall transformation can subsequently be computed.

摘要翻译： 本发明涉及一种计算变换的方法，该方法在描述对象的运动或变形的同时将对象的两个不同图像（10,10'）变换为另一个。 根据该方法首先计算子区域（1,2,3,4,5）的局部变换参数。 通过选择子区域足够小，可以为此目的使用刚性变换。 从至少一个第一预定子区域（1）开始，连续地计算邻近子区域（2,3,4,5）的局部变换参数，每个计算所基于的起始值是已经确定的 相邻子区域的局部变换参数。 使用如此确定的子区域的局部变换参数，可以随后计算整体变换。

公开(公告)号：US20050002556A1

公开(公告)日：2005-01-06

申请号：US10488433

申请日：2002-09-03

申请人： Michael Kaus ,  Juergen Weese ,  Steven Lobregt

发明人： Michael Kaus ,  Juergen Weese ,  Steven Lobregt

IPC分类号： A61B5/107 ,  G06T5/00 ,  G06T7/00 ,  G06T7/60 ,  G06T19/00 ,  G06K9/00

CPC分类号： G06T19/00 ,  G06T7/12 ,  G06T7/149 ,  G06T7/60 ,  G06T2207/20081 ,  G06T2207/30008 ,  G06T2210/41

摘要： The invention relates to a method of measuring geometric variables of a three-dimensional structure contained in an object from at least on image representing the object, having the following steps:—use of a deformable first model describing the structure, the shape of which model can be described by parameters,—adjustment of the first model to the structure in the image,—determination of the parameters at which the first model exhibits optimum conformity with the structure,—use of a deformable second model describing the structure, which second model in shape corresponds to the first model, and which in addition contains at least one geometric variable,—modification of the second model according to the parameters determined, and—derivation of the geometric variable(s) from the modified second model.

摘要翻译： 本发明涉及一种从表示物体的至少一个图像上测量包含在物体中的三维结构的几何变量的方法，具有以下步骤： - 使用描述该结构的可变形的第一模型，其模型的形状 可以通过参数来描述， - 将第一模型调整到图像中的结构， - 确定第一模型与结构最佳一致的参数， - 使用描述结构的可变形第二模型，第二模型 形状对应于第一模型，并且还包括至少一个几何变量，根据确定的参数来修改第二模型，以及从修改的第二模型推导出几何变量。

公开(公告)号：US09129387B2

公开(公告)日：2015-09-08

申请号：US11917937

申请日：2006-06-20

申请人： Olivier Ecabert ,  Peters Jochen ,  Juergen Weese

发明人： Olivier Ecabert ,  Peters Jochen ,  Juergen Weese

IPC分类号： G06F17/50 ,  G06T7/00

CPC分类号： G06T7/0089 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/30004 ,  G06T2207/30008

摘要： The invention relates to an adaptation system for adapting a deformable model comprising a plurality of model elements to an object of interest in an image data set, the adaptation system comprising a selector for selecting at least one image- driven model element from the plurality of model elements and an adapter for adapting the deformable model on the basis of optimizing a model energy of the deformable model, the model energy comprising an internal energy of the plurality of model elements and an external energy of the at least one image-driven model element, thereby adapting the deformable model. By enabling the adaptation system to selectively choose the image- driven model elements, the adaptation system of the current invention allows excluding a poorly adaptable model element from interacting with the image data set and thus from being pulled and/or pushed by the image data set into a wrong location.

摘要翻译： 本发明涉及一种用于将包括多个模型元素的可变形模型适配成图像数据集中的感兴趣对象的自适应系统，所述自适应系统包括用于从多个模型中选择至少一个图像驱动模型元素的选择器 元件和用于在优化可变形模型的模型能量的基础上适配可变形模型的适配器，模型能量包括多个模型元素的内部能量和至少一个图像驱动模型元素的外部能量， 从而适应可变形模型。 通过使自适应系统能够选择性地选择图像驱动的模型元素，本发明的自适应系统允许排除不良适应性模型元素与图像数据集的交互，从而被图像数据集拉拽和/或推动 进入错误的位置。