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公开(公告)号：US20090116715A1
公开(公告)日：2009-05-07
申请号：US12301639
申请日：2007-05-14
申请人： Joerg Bredno , Juergen Weese , Alexandra Groth
发明人： Joerg Bredno , Juergen Weese , Alexandra Groth
摘要： Diagnostic angiograms only provide the projected lumen of a coronary, which is only an indirect measure of blood flow and pressure decline. According to an exemplary embodiment of the present invention, a motion compensated determination of a flow dynamics and a pressure decline for stenosis grading is provided, in which the motion compensation is performed on the basis of a tracking of a first position of a first marker and a second position of a second marker in the projection data set. This may provide for a robust and precise flow dynamics and pressure decline determination.
摘要翻译： 诊断性血管造影仅提供冠状动脉的预计管腔，这仅是血流量和压力下降的间接测量值。 根据本发明的示例性实施例，提供了针对狭窄分级的流动动力学和压力下降的运动补偿确定，其中基于第一标记的第一位置的跟踪和 在投影数据集中的第二标记的第二位置。 这可以提供鲁棒和精确的流动动力学和压力衰减测定。
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公开(公告)号：US20080294038A1
公开(公告)日：2008-11-27
申请号：US12096436
申请日：2006-11-15
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno , Tom Bruijns , Peter Rongen , Roel Hermans , Heidrun Steinhauser
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno , Tom Bruijns , Peter Rongen , Roel Hermans , Heidrun Steinhauser
摘要： A system (900), method (100, 200) and apparatus (600, 700, 800) are provided for analyzing a blood flow in a vascular system from a dynamic diagnostic observation sequence (101) to determine blood flow parameters (112) for further determination of filters, replay speed and finally visualization of the replayed original and filtered sequences. A first embodiment (100) extracts features of the observation and uses these features to select an appropriate model from a database of pre-determined models of vascular system of interest which have associated parameters. These parameters are varied to create an instance of the model that best matches the original observation. A second embodiment (200) visualizes a replay of the original observation (101) and the observation (101′) predicted by the model to highlight differences therebetween. A third embodiment (800) provides filtering and control of the replay speed.
摘要翻译： 提供了一种系统（900），方法（100,200）和装置（600,700,800），用于从动态诊断观察序列（101）分析血管系统中的血流，以确定血流参数（112） 进一步确定滤镜，重放速度以及最终可重播的原始和过滤序列。 第一实施例（100）提取观察的特征并且使用这些特征从具有相关参数的感兴趣的血管系统的预定模型的数据库中选择适当的模型。 改变这些参数以创建与原始观察结果最匹配的模型实例。 第二实施例（200）可视化通过模型预测的原始观察（101）和观察（101'）的重放以突出其间的差异。 第三实施例（800）提供重放速度的过滤和控制。
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3.发明申请公开(公告)号：US20080192887A1
公开(公告)日：2008-08-14
申请号：US11815113
申请日：2006-01-31
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno
CPC分类号： G06T11/003 , A61B6/481 , A61B6/504 , G06T7/0012 , G06T2207/10112 , G06T2207/10116 , G06T2207/30104 , G06T2211/404
摘要： The invention relates to a method and a system for the simultaneous reconstruction of the three-dimensional vessel geometry and the flow characteristics in a vessel system. According to one realization of the method, vessel segments (41) of a parametric models are fitted to differently oriented X-ray projections (Pl, Pk, PN) of the vessel system that are generated during the passage of a bolus of contrast agent, wherein the fitting takes the imaged contrast agent dynamics and physiological a priori knowledge into account. In an alternative embodiment, the vessel geometry is reconstructed progressively along each vessel, wherein a new segment of a vessel is added based on the continuity of the vessel direction, vessel radius and reconstructed contrast agent dynamics.
摘要翻译： 本发明涉及用于同时重建血管系统中三维血管几何形状和流动特征的方法和系统。 根据该方法的一个实现，参数模型的血管段（41）适合于不同取向的X射线投影（P ，P < 在造影剂团中通过期间产生的血管系统，其中拟合物考虑成像的造影剂动力学和生理学先验知识。 在替代实施例中，血管几何沿着每个血管逐渐重建，其中基于血管方向，血管半径和重建的造影剂动力学的连续性，添加血管的新的部分。
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公开(公告)号：US20100121316A1
公开(公告)日：2010-05-13
申请号：US12597361
申请日：2008-04-23
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno
CPC分类号： A61B90/36 , A61B2034/101 , G06T7/75 , G06T2207/30101
摘要： The invention relates to a system (100) for computing a risk, the risk relating to injuring an anatomical structure by a medical device during a medical procedure, the system comprising: a structure unit (110) for obtaining a position of the anatomical structure; a device unit (120) for obtaining a position of the medical device; and a risk unit (130) for computing the risk relating to injuring the anatomical structure, based on the position of the medical device and the position of the anatomical structure. The system (100) may be used for planning a path of a medical device, which path minimizes said risk, or for monitoring said risk during the medical procedure.
摘要翻译： 本发明涉及一种用于计算风险的系统（100），涉及在医疗过程中由医疗设备伤害解剖结构的风险，该系统包括：用于获得解剖结构位置的结构单元（110） 用于获得所述医疗装置的位置的装置单元（120）; 以及风险单元（130），用于基于医疗装置的位置和解剖结构的位置来计算与损伤解剖结构有关的风险。 系统（100）可以用于规划医疗设备的路径，该路径使所述风险最小化，或者用于在医疗过程期间监视所述风险。
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公开(公告)号：US10111726B2
公开(公告)日：2018-10-30
申请号：US12597361
申请日：2008-04-23
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno
摘要： The invention relates to a system (100) for computing a risk, the risk relating to injuring an anatomical structure by a medical device during a medical procedure, the system comprising: a structure unit (110) for obtaining a position of the anatomical structure; a device unit (120) for obtaining a position of the medical device; and a risk unit (130) for computing the risk relating to injuring the anatomical structure, based on the position of the medical device and the position of the anatomical structure. The system (100) may be used for planning a path of a medical device, which path minimizes said risk, or for monitoring said risk during the medical procedure.
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公开(公告)号：US08086001B2
公开(公告)日：2011-12-27
申请号：US12090359
申请日：2006-10-06
申请人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
发明人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
IPC分类号： G06K9/00
摘要： Adaptively controlling an imaging system (200, 205) includes constructing model feature characteristics (105) of a process over time, determining parameters and commands (110) for controlling the imaging system for each state of the process, performing data acquisition (120) for the process, extracting current features (130) of the process from the acquired data, matching (135) the current features (130) with the model feature characteristics (105) to determine a state of the process (140), and controlling the data acquisition based on the state of the process to produce optimized data.
摘要翻译： 自适应地控制成像系统（200,205）包括构建处理过程的模型特征特征（105），确定参数和命令（110），以控制成像系统对于每个处理状态，执行数据采集（120） 该过程从所获取的数据提取过程的当前特征（130），将当前特征（130）与模型特征特征（105）匹配（135）以确定过程（140）的状态，以及控制数据 根据进程的状态获取生成优化数据。
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7.发明授权System, apparatus, and method for reproducible and comparable flow acquisitions 有权用于可重复和可比较的流量采集的系统，装置和方法公开(公告)号：US08340744B2
公开(公告)日：2012-12-25
申请号：US12096995
申请日：2006-12-08
申请人： Joerg Bredno , Alexandra Groth , Juergen Weese , Antonius Johannes Cornelius Bruijns , Peter Maria Johannes Rongen , Ronaldus Petrus Johannes Hermans , Heidrun Steinhauser
发明人： Joerg Bredno , Alexandra Groth , Juergen Weese , Antonius Johannes Cornelius Bruijns , Peter Maria Johannes Rongen , Ronaldus Petrus Johannes Hermans , Heidrun Steinhauser
CPC分类号： G01R33/5635 , A61B5/0275 , A61B5/0456 , A61B6/481 , A61B6/504 , A61B6/507 , A61B8/06 , A61M5/007 , A61M5/1723 , A61M2230/04 , G01R33/281 , G01R33/5601 , G06T7/0012 , G06T7/20 , G06T2207/30101
摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.
摘要翻译： 提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。 一旦知道了心脏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而使准静态，常规流动获取传递到随后的可视化和分析过程。 还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达 因此在获取血流序列时控制主要不需要的变量之一。
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8.发明授权公开(公告)号：US08150490B2
公开(公告)日：2012-04-03
申请号：US11815878
申请日：2006-02-13
申请人： Alexandra Groth , Juergen Weese , Joerg Bredno
发明人： Alexandra Groth , Juergen Weese , Joerg Bredno
IPC分类号： A61B6/00
CPC分类号： A61B6/507 , A61B5/4839 , A61B5/489 , A61B6/481 , A61B6/504 , A61M2005/14292 , G06F19/00 , G06T7/0012 , G06T7/70 , G06T2207/20012 , G06T2207/30101
摘要： An apparatus determines an injection point for targeted drug delivery into a patient's body by injection of the drug into a vessel feeding a target area including a target. To provide the interventionalist with an objective and quantitative assessment of potential drug injection points instead of letting him rely on his subjective impression from the visual inspection of DSA sequences, a processor (4) includes an identification routine (41) for identification of a vessel tree topology of vessels feeding the target area, a flow determination routine (42) for determining the percentage of drug material delivered to said target after injection into different potential injection points in the vessel tree, a selection routine (43) for selecting as optimal injection point the potential injection point resulting in the highest percentage of drug delivery to the target.
摘要翻译： 装置通过将药物注射到进食包括靶的靶区域的血管中来确定靶向药物向患者体内输送的注射点。 为了向介入者提供对潜在药物注射点的客观和定量评估，而不是让他依赖于他对DSA序列的视觉检查的主观印象，处理器（4）包括用于识别血管树的识别程序（41） 供给目标区域的血管的拓扑结构，用于确定在注射到血管树中的不同潜在注射点之后输送到所述靶的药物材料的百分比的流量确定程序（42），用于选择最佳注射点的选择程序 潜在的注射点导致药物递送至目标的最高百分比。
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9.发明申请System, Apparatus, and Method for Repreoducible and Comparable Flow Acquisitions 有权可再生和可比流量采集的系统，仪器和方法公开(公告)号：US20080319309A1
公开(公告)日：2008-12-25
申请号：US12096995
申请日：2006-12-08
申请人： Joerg Bredno , Alexandra Groth , Juergen Weese , Tom Bruijns , Peter M.J. Rongen , Roel Hermans , Heidrun Steinhauser
发明人： Joerg Bredno , Alexandra Groth , Juergen Weese , Tom Bruijns , Peter M.J. Rongen , Roel Hermans , Heidrun Steinhauser
CPC分类号： G01R33/5635 , A61B5/0275 , A61B5/0456 , A61B6/481 , A61B6/504 , A61B6/507 , A61B8/06 , A61M5/007 , A61M5/1723 , A61M2230/04 , G01R33/281 , G01R33/5601 , G06T7/0012 , G06T7/20 , G06T2207/30101
摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.
摘要翻译： 提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。 一旦知道心搏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而将“准静态”常规流量采集传递给随后的可视化和分析过程。 还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达 因此在获取血流序列时控制主要不需要的变量之一。
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公开(公告)号：US20080205723A1
公开(公告)日：2008-08-28
申请号：US12090359
申请日：2006-10-06
申请人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
发明人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
IPC分类号： A61B6/00
摘要： Adaptively controlling an imaging system (200, 205) includes constructing model feature characteristics (105) of a process over time, determining parameters and commands (110) for controlling the imaging system for each state of the process, performing data acquisition (120) for the process, extracting current features (130) of the process from the acquired data, matching (135) the current features (130) with the model feature characteristics (105) to determine a state of the process (140), and controlling the data acquisition based on the state of the process to produce optimized data.
摘要翻译： 自适应地控制成像系统（200,205）包括构建处理过程的模型特征特征（105），确定参数和命令（110），以控制成像系统对于每个处理状态，执行数据采集（120） 该过程从所获取的数据提取过程的当前特征（130），将当前特征（130）与模型特征特征（105）匹配（135）以确定过程（140）的状态，以及控制数据 根据进程的状态获取生成优化数据。
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