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    Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
    53.
    发明授权
    Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof 失效
    具有一氧化氮生物活性的活性氧发生酶抑制剂及其应用

    公开(公告)号：US07067659B2

    公开(公告)日：2006-06-27

    申请号：US10829940

    申请日：2004-04-23

    申请人： Jonathan S. Stamler ,  Eric J. Toone ,  Joshua M. Hare

    发明人： Jonathan S. Stamler ,  Eric J. Toone ,  Joshua M. Hare

    IPC分类号： C07D475/04 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/519

    摘要： A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, e.g., 1,5-bis(3-nitrooxypropyyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle. Where the disorder is heart failure, administration of the enzyme inhibitor mediates amelioration of acute coronary symptoms and/or myocardial infarction.

    摘要翻译： 具有NO供体生物活性的活性氧产生酶抑制剂，例如硝化别嘌呤醇，例如1,5-双（3-硝基氧基丙基）-1,5-二氢-4H-吡唑并[3,4-d]嘧啶-4-酮 可用于治疗心力衰竭，稳定型心绞痛，缺血障碍，缺血再灌注损伤，动脉粥样硬化，镰状细胞病，糖尿病，阿尔茨海默氏病，帕金森病，ALS和哮喘，并获得心脏，骨骼和平滑肌的适当收缩。 在疾病是心力衰竭的地方，酶抑制剂的施用介导急性冠状动脉症状和/或心肌梗死的改善。

    Stable NO-delivering compounds
    54.
    发明授权
    Stable NO-delivering compounds 失效
    稳定的NO-递送化合物

    公开(公告)号：US06488951B2

    公开(公告)日：2002-12-03

    申请号：US10026851

    申请日：2001-12-18

    申请人： Eric J. Toone ,  Jonathan S. Stamler

    发明人： Eric J. Toone ,  Jonathan S. Stamler

    IPC分类号： A61F202

    CPC分类号： A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

    摘要： Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.

    摘要翻译： 公开了包含稳定的S-亚硝酰基和游离醇或游离巯基的新型NO释放化合物。 还公开了制备释放NO的化合物的方法。 该方法包括使多硫醇或硫代醇与亚硝酰化剂反应。 还公开了涂覆有所公开的化合物的医疗装置，通过利用医疗装置和灭菌表面的方法将NO递送到受试者的治疗部位的方法。

    Polymers for delivering nitric oxide in vivo
    57.
    发明授权
    Polymers for delivering nitric oxide in vivo 失效
    用于在体内递送一氧化氮的聚合物

    公开(公告)号：US06232434B1

    公开(公告)日：2001-05-15

    申请号：US09103225

    申请日：1998-06-23

    申请人： Jonathan S. Stamler ,  Eric J. Toone ,  Richard S. Stack

    发明人： Jonathan S. Stamler ,  Eric J. Toone ,  Richard S. Stack

    IPC分类号： C08G7500

    CPC分类号： A61K31/785 ,  A61K47/61 ,  A61K47/6951 ,  A61L29/10 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/42 ,  B82Y5/00 ,  C08B37/0012 ,  C08G75/00 ,  C08L5/16 ,  C09D105/16 ,  G06F19/00 ,  Y10T428/1393

    摘要： Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized —S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: R is an organic radical. Each X′ is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X′ is the same and is a C2-C6 alkylene group, more preferably —CH2—, —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2—. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

    摘要翻译： 公开了每聚合物的每1200原子质量单位衍生自至少一个-SNO基团的新型聚合物。 在一个实施方案中，S-亚硝基化聚合物具有稳定的-S-亚硝酰基。 在另一个实施方案中，通过聚合由以下结构式表示的化合物制备的S-亚硝基化聚合物：R是有机基团。每个X'是独立选择的脂族基团或取代的脂族基团。 优选地，每个X'相同并且是C2-C6亚烷基，更优选-CH 2 - ， - CH 2 CH 2 - ， - CH 2 CH 2 CH 2 - 或-CH 2 CH 2 CH 2 CH 2 -P-，m独立地为正整数，使得p + m更大 本发明的聚合物可以用于涂覆医疗装置以将体内的一氧化氮输送到治疗部位。

    Stable no-delivering compounds
    58.
    发明授权
    Stable no-delivering compounds 失效
    稳定的不输送化合物

    公开(公告)号：US06207855B1

    公开(公告)日：2001-03-27

    申请号：US09103227

    申请日：1998-06-23

    申请人： Eric J. Toone ,  Jonathan S. Stamler

    发明人： Eric J. Toone ,  Jonathan S. Stamler

    IPC分类号： C07C32108

    CPC分类号： A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

    摘要： Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.

    摘要翻译： 公开了包含稳定的S-亚硝酰基和游离醇或游离巯基的新型NO释放化合物。 还公开了制备释放NO的化合物的方法。 该方法包括使多硫醇或硫代醇与亚硝酰化剂反应。 还公开了涂覆有所公开的化合物的医疗装置，通过利用医疗装置和灭菌表面的方法将NO递送到受试者的治疗部位的方法。

    NOVEL MEDICAL USES FOR NO AND NO DONOR COMPOUNDS
    60.
    发明申请
    NOVEL MEDICAL USES FOR NO AND NO DONOR COMPOUNDS 审中-公开
    用于无和无复合化合物的新型医疗用途

    公开(公告)号：US20140314881A1

    公开(公告)日：2014-10-23

    申请号：US14318825

    申请日：2014-06-30

    申请人： James D. Reynolds ,  Jonathan S. Stamler

    发明人： James D. Reynolds ,  Jonathan S. Stamler

    IPC分类号： A01N1/02 ,  A61K31/21 ,  A61K33/00

    CPC分类号： A01N1/0226 ,  A61K31/04 ,  A61K31/21 ,  A61K33/00

    摘要： A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxygen supply. A subject at risk for developing high altitude illness is administered a red blood nitrosylating agent in gaseous form that does not directly release nitric oxide, preferably ethyl nitrite.

    摘要翻译： 使用不直接释放一氧化氮的一氧化氮和/或一氧化氮供体或红细胞亚硝酰化剂（优选亚硝酸乙酯）以促进氧供应来保存身体部分。 处于发展高原病风险的受试者服用不直接释放一氧化氮（优选亚硝酸亚乙酯）的气态形式的红血亚硝酰化剂。