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51.发明授权Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever 有权IL-6的拮抗剂可预防或治疗恶病质，虚弱，疲劳和/或发烧公开(公告)号：US09546213B2
公开(公告)日：2017-01-17
申请号：US13046860
申请日：2011-03-14
IPC分类号： A61K39/395 , C07K16/24 , C12P21/08 , A61K39/00
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
摘要翻译： 本发明涉及使用具有IL-6结合特异性的抗体及其片段以预防或治疗有需要的患者的恶病质，发热，乏力和/或疲劳的治疗方法。 在优选的实施方案中，这些患者将包括显示升高的血清C-反应蛋白水平（或具有发展风险）的那些。 在另一个优选实施例中，优选地改善患者的生存性或生活质量。
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公开(公告)号：US09207270B2
公开(公告)日：2015-12-08
申请号：US13600397
申请日：2012-08-31
申请人： Kenneth G. Caldeira , Alistair K. Chan , Daniel B. Cook , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Thomas J. Nugent, Jr. , Stephen H. Salter , Clarence T. Tegreene , David B. Tuckerman , Thomas Allan Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Kenneth G. Caldeira , Alistair K. Chan , Daniel B. Cook , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Thomas J. Nugent, Jr. , Stephen H. Salter , Clarence T. Tegreene , David B. Tuckerman , Thomas Allan Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01R21/133 , G06Q50/06 , G01D4/00 , G01R22/10
CPC分类号： G01R21/133 , G01D4/00 , G01R22/10 , G06Q50/06
摘要： The present invention may include measuring energy usage of one or more appliances for a selected usage metric, receiving reference energy usage data indicative of energy usage of one or more reference appliances for the selected usage metric, comparing the measured energy usage of the one or more appliances for the selected usage metric to the one or more received sets of reference energy usage data for the selected usage metric, and reporting an amount of energy savings based on the comparison of measured energy usage of the one or more appliances and the one or more received sets of reference energy data.
摘要翻译： 本发明可以包括测量用于所选择的使用度量的一个或多个设备的能量使用，接收指示所选择的使用度量的一个或多个参考设备的能量使用的参考能量使用数据，将所测量的一个或多个 用于所选择的使用度量的设备到所选择的使用度量的一个或多个接收的参考能量使用数据集合，以及基于所测量的一个或多个设备的能量使用与一个或多个设备的比较来报告节能量 接收到参考能量数据集。
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53.发明授权Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy 有权使用单倍体交配策略在酵母中合成异源多聚体多肽的方法公开(公告)号：US08709756B2
公开(公告)日：2014-04-29
申请号：US13598885
申请日：2012-08-30
CPC分类号： C07K16/2896 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K2317/24 , C12N15/81 , C12N15/815
摘要： Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.
摘要翻译： 提供了用于在交配感受态酵母中合成和分泌重组异源多聚体蛋白的方法。 将第一表达载体转化为第一单倍体细胞; 并将第二表达载体转化成第二单倍体细胞。 鉴定转化的单倍体细胞，每个细胞各自合成不相同的多肽，然后遗传交叉或融合。 所得的二倍体菌株用于产生和分泌完全组装和生物功能的杂多聚体蛋白。
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公开(公告)号：US08685254B2
公开(公告)日：2014-04-01
申请号：US12006805
申请日：2008-01-03
申请人： Jeffrey A. Bowers , Kenneth G. Caldeira , Alistair K. Chan , William H. Gates, III , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Stephen H. Salter , Clarence T. Tegreene , Willard H. Wattenburg , Lowell L. Wood, Jr.
发明人： Jeffrey A. Bowers , Kenneth G. Caldeira , Alistair K. Chan , William H. Gates, III , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Stephen H. Salter , Clarence T. Tegreene , Willard H. Wattenburg , Lowell L. Wood, Jr.
CPC分类号： A01G15/00 , B63B35/00 , E02B1/003 , G06Q40/00 , G06Q40/08 , Y02A10/48 , Y02E10/28 , Y02E10/38 , Y10T137/0318 , Y10T137/8593
摘要： A method is generally described which includes environmental alteration. The method includes determining a placement of at least one vessel capable of moving water to lower depths in the water via wave induced downwelling. The method also includes placing the at least one vessel in the determined placement. Further, the method includes generating movement of the water adjacent the surface of the water in response to the placing.
摘要翻译： 通常描述包括环境变化的方法。 该方法包括确定至少一个容器能够通过波浪下降流将水移动到水中的较低深度的位置。 该方法还包括将至少一个容器放置在确定的放置中。 此外，该方法包括响应于放置而产生邻近水表面的水的运动。
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公开(公告)号：US20140067296A1
公开(公告)日：2014-03-06
申请号：US13600397
申请日：2012-08-31
申请人： Kenneth G. Caldeira , Alistair K. Chan , Daniel B. Cook , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Stephen H. Salter , Clarence T. Tegreene , David B. Tuckerman , Thomas Allan Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Kenneth G. Caldeira , Alistair K. Chan , Daniel B. Cook , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , John Latham , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Stephen H. Salter , Clarence T. Tegreene , David B. Tuckerman , Thomas Allan Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： G01R21/133
CPC分类号： G01R21/133 , G01D4/00 , G01R22/10 , G06Q50/06
摘要： The present invention may include measuring energy usage of one or more appliances for a selected usage metric, receiving reference energy usage data indicative of energy usage of one or more reference appliances for the selected usage metric, comparing the measured energy usage of the one or more appliances for the selected usage metric to the one or more received sets of reference energy usage data for the selected usage metric, and reporting an amount of energy savings based on the comparison of measured energy usage of the one or more appliances and the one or more received sets of reference energy data.
摘要翻译： 本发明可以包括测量用于所选择的使用度量的一个或多个设备的能量使用，接收指示所选择的使用度量的一个或多个参考设备的能量使用的参考能量使用数据，将所测量的一个或多个 用于所选择的使用度量的设备到所选择的使用度量的一个或多个接收的参考能量使用数据集合，以及基于所测量的一个或多个设备的能量使用与一个或多个设备的比较来报告节能量 接收到参考能量数据集。
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公开(公告)号：US08637643B2
公开(公告)日：2014-01-28
申请号：US13741887
申请日：2013-01-15
申请人： John Latham , David G. Winkler
发明人： John Latham , David G. Winkler
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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57.发明申请MULTI-COPY STRATEGY FOR HIGH-TITER AND HIGH-PURITY PRODUCTION OF MULTI-SUBUNIT PROTEINS SUCH AS ANTIBODIES IN TRANSFORMED MICROBES SUCH AS PICHIA PASTORIS 审中-公开用于高倍数和高纯度生产多亚种蛋白质的多重策略如转化微生物中的抗体如PICHIA PASTORIS公开(公告)号：US20130045888A1
公开(公告)日：2013-02-21
申请号：US13589584
申请日：2012-08-20
申请人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
发明人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
CPC分类号： C12N15/815 , C07K16/00 , C07K2317/14 , C07K2319/036 , C07K2319/50 , C12N1/16 , C12P21/005 , C12P21/02
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
摘要翻译： 公开了在转化细胞中产生异源多亚基蛋白的方法。 特别地，本公开提供了产生多亚单位蛋白质的改进方法，所述多亚单位蛋白质包括抗体和其它多亚基蛋白质，其可以分泌或不分泌，具有更高的产量和减少不期望的副产物的产生。 在示例性实施方案中，转化的细胞是酵母，例如甲基营养酵母，例如巴斯德毕赤酵母。
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58.发明申请METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY 有权使用髋关节置换策略合成YEAST中异源多聚体的方法公开(公告)号：US20130029880A1
公开(公告)日：2013-01-31
申请号：US13598885
申请日：2012-08-30
CPC分类号： C07K16/2896 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K2317/24 , C12N15/81 , C12N15/815
摘要： Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.
摘要翻译： 提供了用于在交配感受态酵母中合成和分泌重组异源多聚体蛋白的方法。 将第一表达载体转化为第一单倍体细胞; 并将第二表达载体转化成第二单倍体细胞。 鉴定转化的单倍体细胞，每个细胞各自合成不相同的多肽，然后遗传交叉或融合。 所得的二倍体菌株用于产生和分泌完全组装和生物功能的杂多聚体蛋白。
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公开(公告)号：US20120142900A1
公开(公告)日：2012-06-07
申请号：US13277390
申请日：2011-10-20
申请人： Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
发明人： Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
IPC分类号： C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76
摘要： The present invention relates to anti-IL-6 antibodies and antibody fragments having a particular epitopic specificity. These antibodies and antibody fragments have clinical therapeutic and diagnostic applications in treating and detecting disease conditions wherein Il-6 levels are elevated.
摘要翻译： 本发明涉及具有特定表位特异性的抗IL-6抗体和抗体片段。 这些抗体和抗体片段在治疗和检测其中Il-6水平升高的疾病状况方面具有临床治疗和诊断应用。
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60.发明申请Antibodies Specific for Sclerostin and Methods for Increasing Bone Mineralization 审中-公开特异于硬皮蛋白的抗体和增加骨矿化的方法公开(公告)号：US20110206678A1
公开(公告)日：2011-08-25
申请号：US13101455
申请日：2011-05-05
申请人： David G. Winkler , Jiye Shi , John Latham
发明人： David G. Winkler , Jiye Shi , John Latham
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46 , C12N5/18 , C07H21/04 , C12N15/63 , C12N1/00 , C12P21/02 , C12N5/10 , A61P19/08 , A61P19/10
CPC分类号： C07K16/22 , A61K47/643 , A61K47/646 , C07K14/475 , C07K14/51 , C07K16/18 , C07K2317/76 , G01N33/6854 , G01N2333/4704
摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
摘要翻译： 提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。
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