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204 条记录 (耗时 0.037 秒)

    Hyperforin derivatives, use thereof and formulations containing them
    58.
    发明授权
    Hyperforin derivatives, use thereof and formulations containing them 有权
    Hyperforin衍生物，其使用和含有它们的制剂

    公开(公告)号：US06656510B2

    公开(公告)日：2003-12-02

    申请号：US09730536

    申请日：2000-12-07

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K3578

    CPC分类号： A61K31/122 ,  C07C69/013 ,  C07C69/734 ,  C07C69/92

    摘要： The invention relates to compounds of the formula: in which R is a saturated or unsaturated, straight or branched, C1-C22 acyl group, optionally having one or more substituents, which can be the same or different, selected from halogen atoms, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-acylamino groups; a cycloaliphatic or aromatic acyl residue in which the aromatic moiety optionally has one or more substituents, which can be the same or different, selected from halogen atoms, hydroxy, methoxy, amino groups; a glycidic residue in which one or more hydroxy groups are optionally alkylated or acylated. The invention further relates to methods for extracting and extracts of these compounds from Hypericum perforatum as well as their use as active ingredients in antidepression medication.

    摘要翻译： 本发明涉及下式的化合物：其中R是饱和或不饱和的直链或支链C 1 -C 22酰基，任选具有一个或多个可以相同或不同的取代基，可以选自卤素原子，硝基， 氨基，C 1 -C 6烷基氨基，二-C 1 -C 6烷基氨基，C 1 -C 6酰基氨基; 芳族部分任选具有一个或多个选自卤素原子，羟基，甲氧基，氨基中的相同或不同的取代基的脂环族或芳族酰基残基; 其中一个或多个羟基任选被烷基化或酰化的缩水甘油基残基。 本发明还涉及从贯叶连翘提取和提取这些化合物的方法以及它们作为抗抑郁药物中的活性成分的用途。

    Semi-synthetic taxanes with antitumor and antiangiogenetic activities
    59.
    发明授权
    Semi-synthetic taxanes with antitumor and antiangiogenetic activities 有权
    具有抗肿瘤和抗血管发生作用的半合成紫杉烷

    公开(公告)号：US06589979B2

    公开(公告)日：2003-07-08

    申请号：US10187995

    申请日：2002-07-03

    申请人： Ezio Bombardelli ,  Alessandro Pontiroli

    发明人： Ezio Bombardelli ,  Alessandro Pontiroli

    IPC分类号： A61K31337

    CPC分类号： C07D305/14

    摘要： Seco-baccatin III derivatives of formula: wherein R, R1-R4, R1, R11, and R111 are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administering to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed.

    摘要翻译： 本文公开了其中R，R 1 -R 4，R 1，R 11和R 111的式-β-浆果赤霉素III衍生物; 含有浆果赤霉素Ⅲ衍生物的药物组合物; 以及用于治疗动物中的癌症，关节炎和抑制血管生成的方法，其包括向有需要的患者施用治疗有效量的浆果赤霉素Ⅲ衍生物。