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    Extracts of zanthoxylum bungeanum, and pharmaceutical and cosmetic formulations containing same
    3.
    发明授权
    Extracts of zanthoxylum bungeanum, and pharmaceutical and cosmetic formulations containing same 有权
    花椒的提取物，以及含有其的药物和化妆品制剂

    公开(公告)号：US06419950B2

    公开(公告)日：2002-07-16

    申请号：US09749448

    申请日：2000-12-28

    申请人： Ezio Bombardelli ,  Bruno Gabetta

    发明人： Ezio Bombardelli ,  Bruno Gabetta

    IPC分类号： A61K948

    CPC分类号： A61K36/758 ,  A61K8/97 ,  A61Q19/00

    摘要： The extract of the pericarp of Zanthoxylum bungeanum, prepared by extraction with carbon dioxide in supercritical conditions, has remarkable analgesic activity without exerting the local anesthetic activity characteristic of the extracts obtained by solvent means. The product of the present invention is prepared by extracting the pericarp of Zanthoxylurn bungeanum, finely ground or transformed into pellets, with carbon dioxide under pressure conditions ranging from 150 to 300 bars at temperatures ranging from 35 to 55° C.

    摘要翻译： 通过在超临界条件下用二氧化碳提取制备的花椒的果皮提取物具有显着的镇痛作用，而不会发挥通过溶剂方法获得的提取物的局部麻醉活性。 本发明的产品是通过在35至55℃的温度范围内，在150-300巴的压力条件下，用二氧化碳将Zanthoxylurn bungeanum的果皮精细研磨或转化成颗粒来制备的。

    Soya extract, process for its preparation and pharmaceutical composition
    4.
    发明授权
    Soya extract, process for its preparation and pharmaceutical composition 有权
    大豆提取物，其制备方法和药物组成

    公开(公告)号：US06280777B1

    公开(公告)日：2001-08-28

    申请号：US09492921

    申请日：2000-01-28

    申请人： Ezio Bombardelli ,  Bruno Gabetta

    发明人： Ezio Bombardelli ,  Bruno Gabetta

    IPC分类号： A01N6500

    CPC分类号： A61K36/48 ,  Y10S514/811 ,  Y10S514/899

    摘要： A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.

    摘要翻译： 含有每1重量份葡萄糖苷异黄酮的至少13重量％的葡萄糖苷异黄酮含量和0.6〜1.5重量份的3组大豆皂苷的含量的大豆提取物。 此外，含有该提取物的药物组合物和施用提取物以治疗诸如绝经前或绝经后症状的癌症，癌症，例如乳腺癌或前列腺癌或酒精中毒的方法。 提取物通过包括用脂肪醇处理成熟的大豆或无油大豆粉以获得第一提取物的步骤的方法制备; 浓缩第一提取物以形成浓缩的第一提取物; 通过用至少一种脂族烃处理纯化浓缩的第一提取物; 并用水不混溶的脂族醇从纯化的浓缩的第一提取物提取活性成分，得到第二提取物。 优选将最终的提取物浓缩干燥以形成所需的大豆提取物。

    Semi-synthetic taxanes with anti-tumoural activity
    5.
    发明授权
    Semi-synthetic taxanes with anti-tumoural activity 失效
    具有抗肿瘤活性的半合成紫杉烷

    公开(公告)号：US5756776A

    公开(公告)日：1998-05-26

    申请号：US505924

    申请日：1995-07-24

    申请人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo De Bellis

    发明人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo De Bellis

    IPC分类号： A61K31/00 ,  A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/06 ,  C07D305/14

    CPC分类号： C07D305/14

    摘要： The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues. The products of the invention have cytotoxic and anti-tumoural activities and, when suitably formulated, can be administered by injection and/or orally.

    摘要翻译： 本发明涉及通过氧化和10-脱乙酰基浆果赤霉素III的立体特异性还原获得的新衍生物，以及用各种取代的异丝氨酸链连续酯化制备紫杉酚类似物。 本发明的产品具有细胞毒性和抗肿瘤活性，并且当适当配制时，可以通过注射和/或口服施用。

    Extracts of Hypericum perforatum and formulations containing them
    6.
    发明授权
    Extracts of Hypericum perforatum and formulations containing them 失效
    金丝桃提取物和含有它们的制剂

    公开(公告)号：US06428820B2

    公开(公告)日：2002-08-06

    申请号：US09725938

    申请日：2000-11-30

    申请人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo Morazzoni

    IPC分类号： A01N6500

    CPC分类号： A61K36/38 ,  C07C45/78 ,  C07C49/743

    摘要： The invention relates to a method for extracting Hypericum perforatum (St.-Johns-wort) by fractioning water-alcohol, alcohol extracts of the plant with esters of water-immiscible C1-C5 alcohols. The extracts have high activity and are stable over time. The invention also relates to formulations containing the extract.

    摘要翻译： 本发明涉及通过用水不混溶的C1-C5醇的酯分馏水醇，植物的醇提取物来提取贯叶连翘（St.-Johns-wort）的方法。 提取物具有高活性，随时间稳定。 本发明还涉及含有提取物的制剂。

    Colchicine derivatives, the use thereof and formulations containing them
    8.
    发明授权
    Colchicine derivatives, the use thereof and formulations containing them 失效
    秋水仙碱衍生物，其使用和含有它们的制剂

    公开(公告)号：US5880160A

    公开(公告)日：1999-03-09

    申请号：US670878

    申请日：1996-06-27

    申请人： Ezio Bombardelli ,  Bruno Gabetta

    发明人： Ezio Bombardelli ,  Bruno Gabetta

    IPC分类号： A61K31/165 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P19/06 ,  A61P21/02 ,  A61P29/00 ,  A61P35/00 ,  C07C233/32 ,  C07C323/41 ,  C07H15/248 ,  A61K31/16 ,  C07C233/05

    CPC分类号： C07H15/248 ,  C07C233/32 ,  C07C323/41 ,  C07C2103/34 ,  Y10S514/886

    摘要： The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization of the hydroxyl at C.sub.3 of the aromatic ring and at C.sub.10 of the tropolone ring. These novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine but, in comparison with the latter, they are much more active on cells resistant to the usual antiblastics. The compounds can be included in pharmaceutical formulations useful for the intravenous, oral and topical administrations.

    摘要翻译： 本发明涉及具有抗增殖，抗肿瘤，抗炎和肌肉松弛活性的新型秋水仙碱衍生物; 所述衍生物包括用于本发明或在芳环的C 3的羟基衍生化和在氯普罗酮环的C 10之间使用的新型胆碱氮酰胺。 这些新型化合物对与秋水仙素相当的人肿瘤细胞系具有细胞毒性，但与后者相比，它们对通常抗生素耐药性的细胞活性更高。 该化合物可以包含在用于静脉内，口服和局部给药的药物制剂中。