公开(公告)号：US20110172296A1

公开(公告)日：2011-07-14

申请号：US13005508

申请日：2011-01-12

申请人： C. Frank Bennett ,  Susan M. Freier ,  Nicholas M. Dean ,  J. Gordon Foulkes ,  William A. Gaarde

发明人： C. Frank Bennett ,  Susan M. Freier ,  Nicholas M. Dean ,  J. Gordon Foulkes ,  William A. Gaarde

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C07H21/02 ,  A61P17/02

CPC分类号： A61K31/7088 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/3521 ,  C12N2310/3525

摘要： Provided are compounds capable of inhibiting expression of TGF-beta 1 and compositions containing same as well as methods using such compounds for treating fibrotic diseases including the reduction of scarring resulting from wound healing.

摘要翻译： 提供能够抑制TGF-β1的表达的化合物及其含有组合物的化合物以及使用这些化合物治疗纤维化疾病的方法，包括减少由伤口愈合导致的瘢痕形成。

公开(公告)号：US07879992B2

公开(公告)日：2011-02-01

申请号：US11339785

申请日：2006-01-24

申请人： Timothy Vickers ,  Nicholas M. Dean

发明人： Timothy Vickers ,  Nicholas M. Dean

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节MyD88的表达。 组合物包含靶向编码MyD88的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MyD88表达和治疗MyD88表达相关疾病的方法。

公开(公告)号：US20100130595A1

公开(公告)日：2010-05-27

申请号：US12547474

申请日：2009-08-25

申请人： Nicholas M. Dean ,  J. Gordon Foulkes ,  Niall O'Donnell ,  C. Frank Bennett ,  Susan M. Frier

发明人： Nicholas M. Dean ,  J. Gordon Foulkes ,  Niall O'Donnell ,  C. Frank Bennett ,  Susan M. Frier

IPC分类号： A61K31/7088 ,  C07H21/00 ,  C12N5/071 ,  A61P43/00

CPC分类号： C12N15/1136 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2310/3521

摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。

公开(公告)号：US20100041047A1

公开(公告)日：2010-02-18

申请号：US12511437

申请日：2009-07-29

申请人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

发明人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/53 ,  C12N2310/3525

摘要： The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds.

摘要翻译： 本发明尤其提供了选择用于抑制RNA表达的单链寡聚化合物的方法，产生双链寡聚化合物的方法，鉴定优化的双链寡聚化合物的方法，选择优化的单链寡聚化合物的方法 选择优化的双链寡聚化合物的方法，鉴定多功能寡聚化合物的方法，用于优化用于调节RNA表达的靶区选择的方法，优化RNA表达调节的方法等。 本发明进一步提供低聚化合物，长度靶向靶RNA的8-80个核碱基，其中所述寡聚化合物与所述靶RNA杂交并且以单链和双链形式抑制至少50％的RNA水平，以及 多官能寡聚化合物。

公开(公告)号：US20090264502A1

公开(公告)日：2009-10-22

申请号：US12064330

申请日：2006-08-24

申请人： C. Frank Bennett ,  Nicholas M. Dean ,  Kenneth W. Dobie

发明人： C. Frank Bennett ,  Nicholas M. Dean ,  Kenneth W. Dobie

IPC分类号： A61K31/7125 ,  C07H21/02 ,  A61P35/00

CPC分类号： A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/345 ,  C12N2310/3527

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HSP27 in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

摘要翻译： 本文公开了用于调节细胞，组织或动物中HSP27表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

公开(公告)号：US06312900B1

公开(公告)日：2001-11-06

申请号：US09364416

申请日：1999-07-30

申请人： Nicholas M. Dean ,  Robert McKay ,  Loren Miraglia ,  Brenda Baker

发明人： Nicholas M. Dean ,  Robert McKay ,  Loren Miraglia ,  Brenda Baker

IPC分类号： C12Q168

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/3525 ,  C12N2310/3521 ,  C12N2310/3527

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.

摘要翻译： 提供了通过调节活化蛋白1（AP-1）表达来治疗和诊断易于治疗的组合物和方法。 根据本发明的各种实施方案，提供了与c-fos或c-jun，分别编码c-Fos或c-Jun的基因特异性杂交的寡核苷酸。 在优选的实施方案中，提供了通过调节一种或多种AP-1亚基来调节恶性肿瘤的转移的方法。 该方法可以使用本发明的寡核苷酸或调节AP-1或AP-1介导的转录的任何其它试剂来实现。

公开(公告)号：US06214986B1

公开(公告)日：2001-04-10

申请号：US09323743

申请日：1999-06-02

申请人： C. Frank Bennett ,  Nicholas M. Dean ,  Brett P. Monia ,  Brian J. Nickoloff ,  QingQing Zhang

发明人： C. Frank Bennett ,  Nicholas M. Dean ,  Brett P. Monia ,  Brian J. Nickoloff ,  QingQing Zhang

IPC分类号： C07H2104

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3233 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.