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公开(公告)号：US06476029B1
公开(公告)日：2002-11-05
申请号：US09720051
申请日：2001-03-23
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
摘要翻译： 本发明涉及7-烷基 - 和环烷基取代的咪唑并三嗪酮，其制备方法和用作药物，特别是作为cGMP代谢磷酸二酯酶的抑制剂。
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公开(公告)号：US5925674A
公开(公告)日：1999-07-20
申请号：US548403
申请日：1995-10-26
IPC分类号： A01N37/24 , A01N47/06 , A01N47/22 , C07C233/60 , C07C271/48 , C07C323/18 , C07C323/31 , C07C329/06 , A01N47/10 , C07C271/42
CPC分类号： C07C233/60 , A01N37/24 , A01N47/06 , A01N47/22 , C07C271/48 , C07C329/06 , C07C2101/08 , C07C2101/14
摘要： This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.
摘要翻译： 本发明涉及用于防治害虫的下式的环烷基甲酰苯胺。
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53.发明授权7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives 失效7-（1-吡咯烷基）-3-喹诺酮 - 和萘啶酮 - 羧酸衍生物作为抗菌剂和饲料添加剂
公开(公告)号：US5607942A
公开(公告)日：1997-03-04
申请号：US406448
申请日：1995-03-20
申请人： Uwe Petersen , Thomas Schenke , Andreas Krebs , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Schenke , Andreas Krebs , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： A23K20/195 , A61K31/435 , A61K31/47 , A61K31/535 , A61P31/04 , C07D207/14 , C07D215/56 , C07D401/04 , C07D403/04 , C07D407/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D513/04 , C07D513/06 , C07D519/00
CPC分类号： C07D215/56 , C07D207/14 , C07D401/04 , C07D407/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,X.sup.2 is hydrogen, halogen, amino or other radical,R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1,and addition products thereof.
摘要翻译： 7-（1-吡咯烷基）-3-喹诺酮 - 和 - 萘啶酮 - 羧酸衍生物作为抗菌剂和饲料添加剂，其中X 1为卤素，X 2为氢，卤素，氨基或其它基团，式 是烷基，环烷基，任选取代的苯基或其它基团，R 2是氢，烷基或二氧杂环戊基甲基，R 3是A，N是CH，C-卤素等，或与 R1及其加成产物。
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公开(公告)号：US5480879A
公开(公告)日：1996-01-02
申请号：US131253
申请日：1993-10-01
申请人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
发明人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
IPC分类号： A61K31/43 , A61K31/435 , A61K31/47 , A61K31/535 , A61K31/545 , A61P31/04 , C07D417/12 , C07D463/00 , C07D477/00 , C07D477/14 , C07D498/04 , C07D499/88 , C07D501/00 , C07D501/16 , C07D513/06 , C07D519/00 , C07D519/06 , C07D487/04
CPC分类号： C07D477/14 , C07D499/88 , C07D501/00
摘要： The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.
摘要翻译： 本发明涉及与β-内酰胺抗生素连接的喹诺酮羧酸和萘啶酮羧酸的新型衍生物，其盐，其制备方法和含有这些衍生物的抗菌剂。
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公开(公告)号：US5468742A
公开(公告)日：1995-11-21
申请号：US146569
申请日：1993-11-01
申请人： Uwe Petersen , Thomas Himmler , Thomas Schenke , Andreas Krebs , Klaus Grohe , Klaus-Dieter Bremm , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Himmler , Thomas Schenke , Andreas Krebs , Klaus Grohe , Klaus-Dieter Bremm , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D215/56 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/04 , A61K31/47 , A61K31/535 , C07D498/02
CPC分类号： C07D215/56 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
摘要翻译： 本发明涉及新的8-乙烯基和8-乙炔基喹诺酮羧酸，其制备方法，以及含有它们的抗菌剂和饲料添加剂。
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56.发明授权Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them 失效喹诺酮和萘啶酮羧酸衍生物，其制备方法，抗菌组合物和含有它们的饲料添加剂
公开(公告)号：US5453422A
公开(公告)日：1995-09-26
申请号：US151603
申请日：1993-11-12
申请人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D207/12 , C07D211/42 , C07D211/48 , C07D401/04 , C07D405/14 , C07D455/04 , C07D471/04 , C07D487/10 , C07D491/10 , C07D498/06 , C07D498/10 , C07D513/10 , C07D519/00 , A61K31/47
CPC分类号： C07D401/04 , C07D207/12 , C07D211/42 , C07D211/48 , C07D405/14 , C07D455/04 , C07D471/04 , C07D487/10 , C07D491/10 , C07D513/10
摘要： An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,R.sup.2 stands for hydrogen, alkyl having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,R.sup.3 stands for hydrogen or amino,R.sup.4 stands for a radical of the formula ##STR2## A stands for N or C--R.sup.5, whereinR.sup.5 stands for hydrogen, halogen methyl, cyano or nitro or else together with R.sup.1 can form a bridge of the structure ##STR3## or a pharmaceutically utilizable hydrate, acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt of the carboxylic acid when R.sup.2 is hydrogen.
摘要翻译： 其中R1代表各种有机基团，R2代表氢，具有1至4个碳原子的烷基或（5-甲基-2-氧代-1,3-二氧杂环戊烯）的式为“IMAGE”的抗菌活性喹诺酮或萘啶酮羧酸衍生物 -4-基） - 甲基，R 3代表氢或氨基，R 4代表式“IMAGE”或“IMAGE”的基团，A代表N或C-R 5，其中R 5代表氢，卤素甲基，氰基 或硝基，或者与R 1一起形成桥结构，其结构可以是“IMAGE”，“IMAGE”或“IMAGE”或其药学上可利用的水合物，酸加成盐，碱金属盐，碱土金属盐，银盐或胍盐 羧酸，当R2是氢时。
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57.发明授权Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthyridonecarboxylic acids 失效7-（3-氨基 - 和3-氨基 - 甲基-1-吡咯烷基）-3-喹啉酮羧酸和 - 壬基苯甲酰氧基酸的制备
公开(公告)号：US5061712A
公开(公告)日：1991-10-29
申请号：US529016
申请日：1990-05-25
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D227/04 , A61K31/397 , A61K31/435 , A61K31/47 , A61P31/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D227/10 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06 , C07D513/06
CPC分类号： C07D401/04 , C07D207/14 , C07D471/04 , Y02P20/55
摘要： Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##
摘要翻译： 用于制备式（I）的抗菌化合物的方法包括将式IMA的（V）的氧代化合物与式VI的氨基化合物缩合以产生式 （III）使式（III）的化合物与式（II）的化合物反应，得到式（IV）的化合物，然后除去氨基保护基
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公开(公告)号：US08110528B2
公开(公告)日：2012-02-07
申请号：US12294821
申请日：2007-03-28
申请人： Heike Hungenberg , Peter Jeschke , Robert Velten , Thomas Schenke , Wolfram Andersch , Wolfgang Thielert
发明人： Heike Hungenberg , Peter Jeschke , Robert Velten , Thomas Schenke , Wolfram Andersch , Wolfgang Thielert
CPC分类号： A01N43/40 , A01N51/00 , A01N2300/00
摘要： The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) in which R is as defined in the description, and a further known active compound from the class of the neonicotinoids, which combinations are highly suitable for controlling animal pests such as insects.
摘要翻译： 本发明涉及包含至少一种已知的式（I）化合物的新型活性化合物组合物，其中R如说明书中所定义，另外已知的来自新烟碱类的活性化合物，其组合高度适用于 控制动物害虫如昆虫。
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公开(公告)号：US20060128700A1
公开(公告)日：2006-06-15
申请号：US10528601
申请日：2003-09-16
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
IPC分类号： A61K31/538 , A61K31/506 , C07D491/04
CPC分类号： C07D471/04
摘要： The present invention relates to novel morpholine-bridged indazole derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of disorders of the central nervous system.
摘要翻译： 本发明涉及刺激可溶性鸟苷酸环化酶的新型吗啉桥连吲唑衍生物，其制备方法及其用于制备药物的用途，特别是用于治疗中枢神经系统疾病的药物。
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公开(公告)号：US06943163B2
公开(公告)日：2005-09-13
申请号：US10850510
申请日：2004-05-20
申请人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
发明人： Ulrich Niewöhner , Mazen Es-Sayed , Helmut Haning , Thomas Schenke , Gunter Schmidt , Karl-Heinz Schlemmer , Erwin Bischoff , Klaus Dembowsky , Elisabeth Perzborn
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/539 , A61K31/55 , A61K31/5513 , A61K31/675 , A61P7/12 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/00 , A61P15/10 , A61P21/02 , A61P43/00 , C07D487/04 , C07D519/00 , C07F9/6561 , A61P9/12 , A61P13/08
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
摘要翻译： 本发明涉及7-烷基 - 和环烷基取代的咪唑并三嗪酮，其制备方法和用作药物，特别是作为cGMP代谢磷酸二酯酶的抑制剂。
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