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133 条记录 (耗时 0.073 秒)

    Tumor necrosis factor 6α and 6β
    51.
    发明授权
    Tumor necrosis factor 6α and 6β 有权
    肿瘤坏死因子6α和6beta

    公开(公告)号：US07186800B1

    公开(公告)日：2007-03-06

    申请号：US09518931

    申请日：2000-03-03

    申请人： Reiner L. Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    发明人： Reiner L. Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    IPC分类号： C07K14/715 ,  C07K14/435

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Apoptosis Inducing Molecule II and methods of use
    52.
    发明授权
    Apoptosis Inducing Molecule II and methods of use 有权
    细胞凋亡诱导分子II及其使用方法

    公开(公告)号：US06495520B2

    公开(公告)日：2002-12-17

    申请号：US09252656

    申请日：1999-02-19

    申请人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jun Zhang ,  Stephen Ullrich ,  Yifan Zhai

    发明人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jun Zhang ,  Stephen Ullrich ,  Yifan Zhai

    IPC分类号： A61K3818

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  C12N2799/027

    摘要： The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

    摘要翻译： 本发明涉及TNF-配体超家族的新成员。 更具体地，提供编码人细胞凋亡诱导分子II（AIM II）的分离的核酸分子。 还提供了AIM II多肽，载体，宿主细胞以及用于制备其的重组方法也是如此。 本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。 还提供了治疗淋巴结病，异常骨发育，自身免疫和其他免疫系统疾病，移植物抗宿主病，类风湿性关节炎，骨关节炎和抑制肿瘤形成如肿瘤细胞生长的治疗方法。

    Apoptosis inducing molecule II
    53.
    发明授权
    Apoptosis inducing molecule II 失效
    凋亡诱导分子II

    公开(公告)号：US06479254B2

    公开(公告)日：2002-11-12

    申请号：US09027287

    申请日：1998-02-20

    申请人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben

    发明人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben

    IPC分类号： C12P2102

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/411 ,  Y10S930/144

    摘要： The present invention relates to a novel member of the TNF-Ligand superfamily, Apoptosis Inducing Molecule II (AIM II). In particular, isolated nucleic acid molecules are provided encoding the human AIM II protein. AIM II polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, autoimmune disease, graft versus host disease, and to inhibit neoplasia, such as tumor cell growth.

    摘要翻译： 本发明涉及TNF-配体超家族，细胞凋亡诱导分子II（AIM II）的新成员。 特别地，提供编码人AIM II蛋白质的分离的核酸分子。 还提供AIM II多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗淋巴结病，自身免疫疾病，移植物抗宿主病和抑制肿瘤形成如肿瘤细胞生长的治疗方法。

    Therapeutic peptides
    54.
    发明授权
    Therapeutic peptides 失效
    治疗肽

    公开(公告)号：US08748575B2

    公开(公告)日：2014-06-10

    申请号：US13984523

    申请日：2011-06-08

    申请人： Henry Wolfe ,  Reinhard Ebner

    发明人： Henry Wolfe ,  Reinhard Ebner

    IPC分类号： A61K38/04 ,  C07K7/08 ,  C07K7/00 ,  C07K1/107 ,  C07K1/00 ,  A61K38/10 ,  A61K38/00 ,  A61P1/10

    CPC分类号： A61K38/10 ,  A61K38/00 ,  A61K38/03 ,  A61K45/06 ,  C07K4/00 ,  C07K7/08 ,  Y02A50/473

    摘要： Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.

    摘要翻译： 公开了具有鸟苷酸环化酶C激动剂活性的治疗肽。 治疗性肽是具有非天然氨基酸的大肠杆菌STa肽，等熵或D-氨基酸取代基的类似物。 治疗性肽可用于治疗慢性意识障碍便秘，炎性肠病和其他疾病。 还公开了包含治疗性肽的药物组合物。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    57.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 审中-公开
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20100330073A1

    公开(公告)日：2010-12-30

    申请号：US12870394

    申请日：2010-08-27

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/00 ,  C07K16/18

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    58.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 有权
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20090068201A1

    公开(公告)日：2009-03-12

    申请号：US12170333

    申请日：2008-07-09

    申请人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： A61K39/395 ,  A61K38/00 ,  C12N5/06 ,  A61P31/00

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Cancer-linked gene as target for chemotherapy
    60.
    发明申请
    Cancer-linked gene as target for chemotherapy 审中-公开
    癌症相关基因作为化疗靶标

    公开(公告)号：US20050220798A1

    公开(公告)日：2005-10-06

    申请号：US10516476

    申请日：2003-06-04

    申请人： Reinhard Ebner ,  Martin Shea

    发明人： Reinhard Ebner ,  Martin Shea

    IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68 ,  A61K39/395 ,  C07K16/46

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5011 ,  G01N33/574 ,  G01N2500/00

    摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based an their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

    摘要翻译： 癌基因连锁基因序列和衍生的氨基酸序列与其对这些癌症相关基因的表达调节的潜在抗肿瘤剂的测定方法一起公开。 还公开了与所公开的多肽反应的抗体以及使用抗体治疗癌症的方法，例如通过使用该抗体靶向靶向癌细胞的体内用于递送治疗剂的目的。 还描述了使用基因序列进行诊断的方法。