公开(公告)号：US20100192688A1

公开(公告)日：2010-08-05

申请号：US12670715

申请日：2008-07-30

Applicant: Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Romano Hoofman

Inventor： Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Romano Hoofman

IPC: G01N17/04

CPC classification number: G01N17/04

Abstract: A sensor senses a characteristic of an environment, e.g., humidity. The sensor has a substrate with strips of material that is sensitive to corrosion as a result of the characteristic. The strips are configured to respond differently to the characteristic. By means of repeatedly measuring the resistances of the strips, the environment can be monitored in terms of accumulated exposure to the characteristic. The strips are manufactured in a semiconductor technology so as to generate accurate sensors that behave predictably.

Abstract translation: 传感器感测环境的特性，例如湿度。 传感器具有由于特性而对腐蚀敏感的材料条带的基板。 条带被配置为对特性做出不同的响应。 通过重复测量条的电阻，可以根据特征的累积暴露来监测环境。 这些条以半导体技术制造，以便产生可预测地行为的精确传感器。

公开(公告)号：US20080214920A1

公开(公告)日：2008-09-04

申请号：US11995846

申请日：2006-07-11

Applicant: Matthias Merz ,  Youri Ponomarev ,  Remco Pijnenburg

Inventor： Matthias Merz ,  Youri Ponomarev ,  Remco Pijnenburg

IPC: A61B5/04

CPC classification number: A61B5/04001 ,  A61B5/6805 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0543 ,  A61N1/0551 ,  B82Y15/00

Abstract: An apparatus and method for improving electrical contact between an implanted device (10) for recording or stimulating neuronal activity and surrounding tissue (12) (e.g., brain tissue, nerve fibers, etc.). In an exemplary embodiment, a nanometer sized topographic structure (36, 136) (e.g., a nanometer scale pillar) is processed for electrical connection with a corresponding electrode (30, 32) of the implanted device (10). The nanometer scale topographic structure (36, 136) bridges a gap (26) between the implanted device (10) and surrounding tissue (12), thus improving neuron-electrode coupling therebetween. The present disclosure can also be extended to any application where capacitive coupling to single or multiple cells (20) can be used for sensing and/or stimulation thereof.

Abstract translation: 一种用于改善用于记录或刺激神经元活动的植入装置（10）与周围组织（12）（例如脑组织，神经纤维等）之间的电接触的装置和方法。 在示例性实施例中，处理纳米尺度的地形结构（例如纳米尺度柱）（例如纳米尺度的柱），以与植入装置（10）的对应电极（30,32）电连接。 纳米级地形结构（36,136）桥接植入装置（10）和周围组织（12）之间的间隙（26），从而改善其间的神经元 - 电极耦合。 本公开还可以扩展到任何应用，其中可将单个或多个单元（20）的电容耦合用于感测和/或刺激它们。

公开(公告)号：US20080200967A1

公开(公告)日：2008-08-21

申请号：US12066690

申请日：2006-09-13

Applicant: Youri Ponomarev ,  Matthias Merz ,  Remco Pijnenburg

Inventor： Youri Ponomarev ,  Matthias Merz ,  Remco Pijnenburg

IPC: A61N1/04

CPC classification number: A61N1/0551 ,  A61N1/40

Abstract: An apparatus and method for electrostimulation treatment of neurological diseases is disclosed herein. The apparatus and method include an array (22) of sub-micron (and sub-cell size) FET electrodes (24) that are capacitively coupled to nervous system elements (both neurons (50) and axons (66)) as a replacement for traditional metal shanks in both single- and multi-electrode(s) electrostimulation implantable devices. By using such an approach, significant improvements in selectivity, power consumption and biocompatibility can be achieved, as well as relying on mainstream IC manufacture techniques for the manufacture thereof, making it cost-effective. The present disclosure can also be extended to any application where capacitive coupling to single or multiple cells can be used for sensing and/or stimulation thereof.

Abstract translation: 本文公开了神经疾病的电刺激治疗的装置和方法。 该装置和方法包括电容耦合到神经系统元件（神经元（50）和轴突（66））的亚微米（和子电池尺寸）FET电极（24）的阵列（22） 单电极和多电极电刺激可植入装置中的传统金属柄。 通过使用这种方法，可以实现选择性，功率消耗和生物相容性的显着改善，以及依靠主流IC制造技术来制造它，使其具有成本效益。 本公开还可以扩展到任何可以将单个或多个单元的电容耦合用于感测和/或刺激的应用。