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    Methods and apparatus for micro-fluidic analytical chemistry
    53.
    发明申请
    Methods and apparatus for micro-fluidic analytical chemistry 审中-公开

    公开(公告)号：US20050199299A1

    公开(公告)日：2005-09-15

    申请号：US11114396

    申请日：2005-04-26

    申请人： Hans Schick ,  Michael Balley ,  Thomas Dykas

    发明人： Hans Schick ,  Michael Balley ,  Thomas Dykas

    IPC分类号： F16K11/074 ,  G01N30/20

    CPC分类号： G01N30/20 ,  F16K11/074 ,  Y10T137/86863

    摘要： Improved valve and methods for analytical techniques and systems. The valve includes a main housing, together with a rotor and stator. The stator has openings therethrough which allow for fluid communication between tubing when connected to the valve, and one surface of the rotor. Ferrules can be used with a clamping assembly to tightly connect the tubing to the valve in a way which separates the clamp assemblies (for ease of connection and disassembly), yet still provides close proximity between the fluid connections. In one embodiment, a series of two or more discrete elements, which can be selectively moved relative to one another, are located within the valve in a “stacked” configuration. Each of the discrete elements includes at least one feature useful for performing chemical analysis, such as sample loops, columns, detectors, mixers and the like, all of which are useful in chromatography.

    Method for synthesizing oxetan-2-ones and intermediates for their preparation
    54.
    发明授权
    Method for synthesizing oxetan-2-ones and intermediates for their preparation 失效
    合成氧杂环丁烷-2-酮及其制备方法

    公开(公告)号：US5902886A

    公开(公告)日：1999-05-11

    申请号：US8057

    申请日：1998-01-16

    申请人： Hans Schick ,  Christine Wedler

    发明人： Hans Schick ,  Christine Wedler

    IPC分类号： C07C45/41 ,  C07C47/198 ,  C07C47/277 ,  C07C69/708 ,  C07D305/12

    CPC分类号： C07D305/12 ,  C07C45/41 ,  C07C47/198 ,  C07C47/277 ,  C07C69/708 ,  Y02P20/55

    摘要： A method is described for the synthesis of oxetan-2-ones comprising protection of the hydroxy group of an hydroxy ester with an acid-labile acetal protecting group, reduction of this O-protected hydroxy ester to an O-protected hydroxy aldehyde, condensation of this aldehyde with a metal enolate of an activated carboxylic acid derivative and spontaneous deprotection of the hydroxy group during the acidic workup procedure. Using the new O-protected hydroxy aldehydes as intermediates the oxetan-2-ones can be obtained after separation in diastereomerically and enantiomerically pure form, in a remarkably reduced number of steps, and in a significantly improved overall yield.

    摘要翻译： 描述了一种用于合成氧杂环丁烷-2-酮的方法，其包括用酸不稳定的缩醛保护基保护羟基酯的羟基，将该O-保护的羟基酯还原成O-保护的羟基醛，缩合 该醛与活化的羧酸衍生物的金属烯醇化物在酸性后处理过程中自发脱保护羟基。 使用新的O-保护的羟基醛作为中间体，可以以非常非对映和对映体纯的形式分离，以显着减少的步骤数量和显着提高的总产率获得氧杂环丁烷-2-酮。

    Manufacture of a modified titanium component for Ziegler-Natta catalysts
    55.
    发明授权
    Manufacture of a modified titanium component for Ziegler-Natta catalysts 失效
    制造用于齐格勒 - 纳塔催化剂的改性钛组分

    公开(公告)号：US3977997A

    公开(公告)日：1976-08-31

    申请号：US533144

    申请日：1974-12-16

    申请人： Hans Schick ,  Heinz Mueller-Tamm ,  Peter Hennenberger

    发明人： Hans Schick ,  Heinz Mueller-Tamm ,  Peter Hennenberger

    IPC分类号： C08F4/00 ,  C01G23/02 ,  C08F4/16 ,  C08F4/60 ,  C08F4/64 ,  C08F110/00 ,  B01J31/02

    CPC分类号： C08F110/00 ,  Y10S526/906

    摘要： A process for the manufacture of a modified titanium-containing component of a Ziegler-Natta catalyst for the polymerization of C.sub.3-6 .alpha.-monoolefins, wherein a specific titanium-containing compound and a specific phosphorus-containing compound are dry-milled at a specific grinding acceleration in a vibratory ball mill. The characteristic feature of the process of the invention is that a mill is used which has a specific useful volume and the mill is initially charged with a specific amount of the titanium-containing compound, which is milled at a low temperature while the phosphorus-containing compound is gradually added, whereupon milling is continued while the temperature of the process material is gradually raised to a specific value and maintained at said value for a specific period of time, whereupon, if desired, milling is again continued at a lower temperature for a specific period of time. In this manner, modified titanium-containing components are obtained which in the polymerization process produce highly reproducible yields of polymer.

    摘要翻译： 制备用于C3-6α-单烯烃聚合的齐格勒 - 纳塔催化剂的改性含钛组分的方法，其中特定的含钛化合物和特定的含磷化合物在特定的 在振动球磨机中研磨加速度。 本发明方法的特征在于，使用具有特定有用体积的研磨机，并且最初将研磨机装入特定量的在低温下研磨的含钛化合物，同时含磷 逐渐添加化合物，随后继续研磨，同时将工艺材料的温度逐渐升高至特定值，并将其保持在所述值一段特定的时间段内，因此，如果需要，再次在较低温度下继续研磨以进行 具体一段时间。 以这种方式，获得了改性的含钛组分，其在聚合过程中产生高度可重复的聚合物产率。

    Manufacture of a titanium-containing component for catalysts of the Ziegler-Natta type
    57.
    发明授权
    Manufacture of a titanium-containing component for catalysts of the Ziegler-Natta type 失效
    制造齐格勒 - 纳塔型催化剂的含钛组分

    公开(公告)号：US4154700A

    公开(公告)日：1979-05-15

    申请号：US855876

    申请日：1977-11-30

    申请人： Heinz Mueller-Tamm ,  Hans Schick ,  James F. R. Jaggard ,  Johann Nickl

    发明人： Heinz Mueller-Tamm ,  Hans Schick ,  James F. R. Jaggard ,  Johann Nickl

    IPC分类号： C08F4/00 ,  C01G23/02 ,  C08F4/60 ,  C08F4/64 ,  C08F10/00

    CPC分类号： C08F10/00

    摘要： A process for the manufacture of a titanium-containing component of a catalyst for the polymerization of monoolefins by the Ziegler-Natta method by milling (a) a particular titanium-containing compound, viz. a titanium trichloride/aluminum trichloride complex and (b) a particular ether with one another, in which process (1) a vibratory ball mill producing a particular milling acceleration is used, (2) the mill is first charged with the titanium-containing compound (a) and may or may not then be run for some time in the absence of diluents, (3) while milling, the ether (b) is added at a particular rate, continuously or in small portions, and in the absence of diluents, thereafter (4) the grist is brought to an elevated temperature, while milling, and is kept at this temperature until from 6 to 85% of the aluminum trichloride originally present in a bonded form in the titanium-containing compound (a) have been eliminated from the said compound (a), after which (5) the product obtained according to (4) is washed with a hydrocarbon and then (6) the product obtained in accordance with (5) is dried and milled for a certain length of time at a low temperature in the absence of a diluent. Polyolefins of high stereoregularity can be obtained in a high specific yield by means of the catalyst component manufactured according to the invention.

    摘要翻译： 用于通过齐格勒 - 纳塔法通过研磨（a）特定的含钛化合物制造用于单烯烃聚合的催化剂的含钛组分的方法， 三氯化钛/三氯化铝配合物和（b）特定的醚，其中使用生产特定研磨加速度的振动球磨机，（2）首先将研磨机装入含钛化合物 （a），并且在没有稀释剂的情况下可以运行一段时间，（3）在研磨时，以特定速率，连续地或以小部分加入乙醚（b），并且在没有稀释剂的情况下 （4）在研磨时将砂轮升至高温，并保持在该温度下，直到含钛化合物（a）中最初以粘合形式存在的三氯化铝的6至85％为 从所述化合物（a）中除去，然后（5）将根据（4）获得的产物用烃洗涤，然后（6）将根据（5）获得的产物干燥并研磨一定长度的 在不存在稀释剂的情况下在低温下进行。 可以通过根据本发明制备的催化剂组分以高比产率获得高立构规整性的聚烯烃。

    Cyclohexylurea compounds
    59.
    发明授权
    Cyclohexylurea compounds 失效
    环己基脲化合物

    公开(公告)号：US07348354B2

    公开(公告)日：2008-03-25

    申请号：US11126161

    申请日：2005-05-11

    申请人： Claudia Hinze ,  Hans Schick

    发明人： Claudia Hinze ,  Hans Schick

    IPC分类号： A61K31/404 ,  C07D209/04

    CPC分类号： C07C335/14 ,  C07C275/24 ,  C07C275/26 ,  C07C2601/14 ,  C07D209/14 ,  C07D209/18

    摘要： Cyclohexylurea compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and the use of such compounds as pharmaceutically active agents with nociceptin/ORL1 receptor system activity for treating pain or other conditions associated with the nociceptin/ORL1 receptor system.

    摘要翻译： 对应于式I的环己基脲化合物，其制备方法，含有它们的药物组合物，以及这些化合物作为药物活性剂与伤害感受肽/ ORL1受体系统活性的用途，用于治疗与伤害感受肽/ ORL1受体系统相关的疼痛或其它病症。