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154 条记录 (耗时 0.07 秒)

    Antibodies to cytokine receptor ZCYTOR17
    52.
    发明授权
    Antibodies to cytokine receptor ZCYTOR17 有权
    细胞因子受体ZCYTOR17的抗体

    公开(公告)号：US08309692B2

    公开(公告)日：2012-11-13

    申请号：US13090316

    申请日：2011-04-20

    申请人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    发明人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K14/00

    CPC分类号： C07K14/715

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    METHODS FOR DETECTING MODULATORS OF CYTOKINE RECEPTOR ZALPHA11
    54.
    发明申请
    METHODS FOR DETECTING MODULATORS OF CYTOKINE RECEPTOR ZALPHA11 有权
    检测细胞因子受体ZALPHA11的调节剂的方法

    公开(公告)号：US20120208236A1

    公开(公告)日：2012-08-16

    申请号：US13339779

    申请日：2011-12-29

    申请人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    发明人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    IPC分类号： C12P21/06

    CPC分类号： C07H21/04 ,  C07K14/715 ,  C07K16/1232 ,  C07K16/2866 ,  C07K2317/32 ,  C07K2319/00

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    Methods for detecting modulators of cytokine receptor zalpha11
    56.
    发明授权
    Methods for detecting modulators of cytokine receptor zalpha11 有权
    检测细胞因子受体zalpha11调节剂的方法

    公开(公告)号：US08110372B2

    公开(公告)日：2012-02-07

    申请号：US13039459

    申请日：2011-03-03

    申请人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    发明人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    IPC分类号： G01N33/53 ,  G01N33/531 ,  G01N33/532 ,  C07K14/00 ,  C07K14/52

    CPC分类号： C07H21/04 ,  C07K14/715 ,  C07K16/1232 ,  C07K16/2866 ,  C07K2317/32 ,  C07K2319/00

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。