公开(公告)号：US5196530A

公开(公告)日：1993-03-23

申请号：US848939

申请日：1992-03-10

申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

IPC分类号： C07D499/00 ,  C07D499/86 ,  C07D499/87

CPC分类号： C07D499/00

摘要： The present invention provides a process for preparing a 2-exo-methylenepenam derivative represented by the formula (2), the process being characterized by reacting an allenyl .beta.-lactum compound represented by the formula (1) with a metallic reducing agent, in which R.sup.1, R.sup.2, R.sup.3 and X are defined in the specification. ##STR1##

公开(公告)号：US4891369A

公开(公告)日：1990-01-02

申请号：US123631

申请日：1987-11-23

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi ,  Tomoyasu Ohno

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D499/44 ,  C07D499/86

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Disclosed are 2.beta.-substituted-methylpenicillanic acid compounds of the formula ##STR1## wherein n is 0, 1 or 2; and ##STR2## is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.These compounds are useful as .beta.-lactamase inhibitor.

公开(公告)号：US4798890A

公开(公告)日：1989-01-17

申请号：US186693

申请日：1988-04-21

申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi

发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi

IPC分类号： C07D205/08 ,  C07D205/09 ,  C07D205/095 ,  C07D401/12 ,  C07D417/12 ,  C07B45/00 ,  C07D ,  C07D401/06 ,  C07D403/12

CPC分类号： C07D205/095 ,  C07D205/09

摘要： A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formulaR.sup.3 SO.sub.2 H (VII)wherein R.sup.3 is defined above.

摘要翻译： 制备式（I）表示的氮杂环丁酮衍生物的方法，其中R 1是氢，卤素或低级烷氧基，R 2是氢，卤素，低级烷氧基，氨基或基团（其中R 5是取代的或 未取代的苯基，取代或未取代的苯基甲基，取代或未取代的苯氧基甲基或取代或未取代的苯甲酰基），或R 1和R 2一起为羰基，R 3为取代或未取代的苯基，且R 4为氢，任选取代的烃残基或酰基 ，衍生自无机酸或有机酸的甲硅烷基，磺酰基或膦酰基，该方法包括使由式（VI）表示的二硫代氮杂环丁酮衍生物（其中R 1，R 2和R 4如上所定义）和R 9是取代或未取代的， 含有由式R3SO2H（Ⅶ）表示的化合物，其中R3定义如上的化合物。

公开(公告)号：US4599151A

公开(公告)日：1986-07-08

申请号：US711922

申请日：1985-03-15

申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

IPC分类号： C25B3/04 ,  C07D499/00 ,  C07D499/06 ,  C07D499/44 ,  C25B3/00 ,  C25B3/06

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： This invention provides a process for preparing a 2,2-bishalomethylpenam derivative represented by the formula ##STR1## wherein R.sup.1 represents a lower alkyl group, aryl group, arylmethyl group, arylcarbonyl group or aryloxymethyl group, R.sup.2 represents a carboxyl-protecting group, X.sup.1 and X.sup.2 are the same or different and represent a halogen atom, the process being characterized in that a disulfide represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and X.sup.1 are as defined above and R.sup.3 represents an aryl group or heterocyclic group is subjected to an electrolytic reaction in a solvent in the presence of a halogen acid and/or halogen salt.

摘要翻译： 本发明提供一种制备式（I）表示的2,2-二油基甲基联苯胺衍生物的方法，其中R1表示低级烷基，芳基，芳基甲基，芳基羰基或芳氧基甲基，R2表示羧基保护基 基团，X1和X2相同或不同，表示卤素原子，该方法的特征在于由式（II）表示的二硫化物，其中R 1，R 2和X 1如上所定义，R 3表示芳基 或杂环基在卤素酸和/或卤素盐的存在下在溶剂中进行电解反应。

公开(公告)号：US4482435A

公开(公告)日：1984-11-13

申请号：US406518

申请日：1982-08-09

申请人： Sigeru Torii ,  Hideo Tanaka ,  Takashi Shiroi

发明人： Sigeru Torii ,  Hideo Tanaka ,  Takashi Shiroi

IPC分类号： C07D513/04 ,  C25B3/04 ,  C25B3/00

CPC分类号： C07D513/04 ,  C25B3/04

摘要： This invention provides a process for preparing a thiazolidine compound of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, alkyl group, aralkyl group, aryl group or aryloxymethyl group, and R.sup.2 represents a hydrogen atom or a group ##STR2## wherein R.sup.3 represents a hydrogen atom, alkyl group, halogenated alkyl group, benzyl group or silyl group, and X represents a hydrogen atom, halogen atom, hydroxy group, alkoxy group or acyloxy group, the process comprising electrolyzing a thiazoline compound represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above, in a mixture comprising a perchloric acid aqueous solution and an organic solvent.

摘要翻译： 本发明提供了制备式（I）的噻唑烷化合物的方法，其中R 1表示氢原子，烷基，芳烷基，芳基或芳氧基甲基，R 2表示氢原子或基团 其中R3表示氢原子，烷基，卤代烷基，苄基或甲硅烷基，X表示氢原子，卤素原子，羟基，烷氧基或酰氧基，该方法包括电解由式 在其中R 1和R 2如上定义的含有高氯酸水溶液和有机溶剂的混合物中的图像（II）。

公开(公告)号：US4120764A

公开(公告)日：1978-10-17

申请号：US869409

申请日：1978-01-16

申请人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

发明人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

IPC分类号： C25B3/02 ,  C07C155/10

CPC分类号： C25B3/02

摘要： A process for producing a tetraalkylthiuram disulfide which comprises electrolytically oxidizing a dialkylammonium dialkyldithiocarbamate having the formula ##STR1## wherein each R represents an alkyl group having from 1 to 4 carbon atoms, in the presence or absence of a supporting electrolyte to produce a tetraalkylthiuram disulfide, the electrolytic oxidation being carried out in one or more solvents which dissolve at least one of the starting dialkylammonium dialkyldithiocarbamate and the resulting tetraalkylthiuram disulfide.

摘要翻译： 一种生产四烷基秋兰姆二硫化物的方法，其包括电解氧化具有式“IMAGE”的二烷基二烷基二硫代氨基甲酸二烷基铵，其中每个R表示具有1至4个碳原子的烷基，在存在或不存在支持电解质的情况下，产生四烷基秋兰姆二硫化物， 电解氧化在一种或多种溶剂中进行，所述溶剂溶解起始二烷基二烷基二硫代氨基甲酸烷基酯和所得的四烷基秋兰姆二硫化物中的至少一种。

公开(公告)号：US07931782B2

公开(公告)日：2011-04-26

申请号：US10577510

申请日：2004-03-26

申请人： Sigeru Torii ,  Kouichi Miki

发明人： Sigeru Torii ,  Kouichi Miki

IPC分类号： B01D1/00 ,  B01D3/10 ,  B01D3/34 ,  B01D3/42 ,  B01D5/00

CPC分类号： B01D1/0047 ,  B01D1/0052 ,  B01D1/02 ,  B01D1/14 ,  B01D3/10 ,  B01D3/346 ,  B01D5/0063 ,  B01D5/009 ,  G01N2001/4066 ,  Y10S159/16 ,  Y10S159/901 ,  Y10S203/11

摘要： A method of recovering a liquid medium from a mixture containing the liquid medium, the method including: (a) blowing a first gas into the mixture containing the liquid medium to vaporize the liquid medium, in a first vaporizing means, thereby to form a second gas containing which is a mixture of the first gas and vaporized liquid medium; (b) continuously dropwise feeding the mixture containing the liquid medium into a second vaporizing means and counter-flowingly contacting the mixture containing the liquid medium, with the second gas to vaporize additional liquid medium to form a third gas which is a mixture of the second gas and additional vaporized liquid medium; and (c) feeding the third gas into a condensing means to condense the vaporized liquid medium into a liquid and separate the first gas, which is then blown into the first vaporizing means in step (a).

摘要翻译： 一种从含有液体介质的混合物中回收液体介质的方法，所述方法包括：（a）在第一蒸发装置中将第一气体吹入含有液体介质的混合物中以使液体介质蒸发，由此形成第二气体 含有第一气体和汽化液体介质的混合物的气体; （b）连续地将含有液体介质的混合物逐滴送入第二蒸发装置，并使包含液体介质的混合物与第二气体相反流接触，以蒸发附加的液体介质以形成第三气体，其是第二气体的混合物 气体和附加汽化液体介质; 和（c）将第三气体进料到冷凝装置中以将蒸发的液体介质冷凝成液体并分离第一气体，然后将其吹入步骤（a）中的第一蒸发装置。

公开(公告)号：US20080035467A1

公开(公告)日：2008-02-14

申请号：US10577510

申请日：2004-03-26

申请人： Sigeru Torii ,  Kouichi Miki

发明人： Sigeru Torii ,  Kouichi Miki

IPC分类号： B01D3/14 ,  B01D3/34

CPC分类号： B01D1/0047 ,  B01D1/0052 ,  B01D1/02 ,  B01D1/14 ,  B01D3/10 ,  B01D3/346 ,  B01D5/0063 ,  B01D5/009 ,  G01N2001/4066 ,  Y10S159/16 ,  Y10S159/901 ,  Y10S203/11

摘要： A method for recovering a liquid medium, comprising gas to be compulsorily contacted with the liquid medium to gasify the liquid medium, and condensing the gasified medium, and a device for recovering a liquid medium. Further, the present invention is directed to a device for recovering a liquid medium, wherein the device comprises: a gasifying means for bringing gas into contact with a mixed liquid comprising a liquid medium and a nonvolatile substance to gasify the liquid medium; a condensing-separating means for cooling the gas and the gasified medium fed from the gasifying means to separate the condensed medium from the separated gas; and a gas feeding means for feeding the separated gas as the gas to the gasifying means.

摘要翻译： 一种用于回收液体介质的方法，包括与液体介质强制接触的气体，以使液体介质气化，并冷凝气化介质，以及用于回收液体介质的装置。 此外，本发明涉及一种用于回收液体介质的装置，其中该装置包括：气体装置，用于使气体与包括液体介质和不挥发物质的混合液体接触，以使液体介质气化; 用于冷却气体的冷凝分离装置和从气化装置供给的气化介质，用于将冷凝介质与分离气体分离; 以及用于将分离的气体作为气体供给到气化装置的气体供给装置。

公开(公告)号：US4336202A

公开(公告)日：1982-06-22

申请号：US264463

申请日：1981-05-18

申请人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

发明人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

IPC分类号： C07C49/517 ,  C07D209/08 ,  C07D307/83 ,  C07C49/403

CPC分类号： C07D307/83 ,  C07C49/517 ,  C07D209/08

摘要： Novel cyclohexanone derivatives of general formula: ##STR1## (wherein R.sup.1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: ##STR2## (wherein R.sup.1 and R.sup.2 each is a hydrocarbon group of 1 to 15 carbon atoms) are produced by an electrooxidative coupling of 1,3-cyclohexanedione with a vinyl ether of general formula:CH.sub.2 .dbd.CH-O-R.sup.1(wherein R.sup.1 is as defined above) in the presence or absence of an alcohol of general formula:R.sup.2 OH(wherein R.sup.2 is as defined above). These new cyclohexanone derivatives can be easily converted to N-substituted or unsubstituted-4-oxo-4,5,6,7-tetrahydroindoles, which are of value as intermediates for the production of N-substituted or unsubstituted-4-hydroxyindoles and, thence, to pindolol and its analogs.

摘要翻译： 新型的通式为：IMA（其中R 1为1至15个碳原子的烃基）的环己酮衍生物和通式为新的环己酮衍生物：其中R1和R2各自为1至15个碳原子的烃基 原子）通过在通式R 2 OH的存在或不存在的情况下，通过1,3-环己二酮与通式为CH 2 = CH-O-R 1（其中R 1如上定义）的乙烯基醚的电氧偶合而产生 （其中R2如上所定义）。 这些新的环己酮衍生物可以容易地转化成N-取代或未取代的-4-氧代-4,5,6,7-四氢吲哚，它们作为制备N-取代或未取代的4-羟基吲哚的中间体， 因此，对吲哚洛尔及其类似物。