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33 条记录 (耗时 0.053 秒)

    Process for preparing 2,2-bishalomethylpenam derivatives
    1.
    发明授权
    Process for preparing 2,2-bishalomethylpenam derivatives 失效
    2,2-二油基甲基衍生物的制备方法

    公开(公告)号：US4599151A

    公开(公告)日：1986-07-08

    申请号：US711922

    申请日：1985-03-15

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

    IPC分类号： C25B3/04 ,  C07D499/00 ,  C07D499/06 ,  C07D499/44 ,  C25B3/00 ,  C25B3/06

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： This invention provides a process for preparing a 2,2-bishalomethylpenam derivative represented by the formula ##STR1## wherein R.sup.1 represents a lower alkyl group, aryl group, arylmethyl group, arylcarbonyl group or aryloxymethyl group, R.sup.2 represents a carboxyl-protecting group, X.sup.1 and X.sup.2 are the same or different and represent a halogen atom, the process being characterized in that a disulfide represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and X.sup.1 are as defined above and R.sup.3 represents an aryl group or heterocyclic group is subjected to an electrolytic reaction in a solvent in the presence of a halogen acid and/or halogen salt.

    摘要翻译： 本发明提供一种制备式（I）表示的2,2-二油基甲基联苯胺衍生物的方法，其中R1表示低级烷基，芳基，芳基甲基，芳基羰基或芳氧基甲基，R2表示羧基保护基 基团，X1和X2相同或不同，表示卤素原子，该方法的特征在于由式（II）表示的二硫化物，其中R 1，R 2和X 1如上所定义，R 3表示芳基 或杂环基在卤素酸和/或卤素盐的存在下在溶剂中进行电解反应。

    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative
    2.
    发明授权
    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative 失效
    制备噻唑基氮杂环丁酮和2-外 - 亚甲基台am am嗪衍生物的方法

    公开(公告)号：US5288860A

    公开(公告)日：1994-02-22

    申请号：US3024

    申请日：1993-01-11

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/12 ,  C07D499/87 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D499/00 ,  Y02P20/55

    摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

    摘要翻译： 本发明提供由式（1）表示的噻唑并氮杂环丁酮衍生物，其中R 1是具有或不具有取代基的苯基，具有或不具有取代基的甲基或基团，R3是具有或不具有取代基的苯基， 不具有取代基，R2为氢原子或羧酸保护基，及其制备方法。 本发明进一步提供了制备2-异亚甲基台内叶酸衍生物的方法，其特征在于水解上述式（1）的噻唑并氮杂环丁酮衍生物的噻唑啉环以进行再循环，得到式（1）所示的2-外 - 亚甲基山梨醇衍生物， 图像（3）其中R1和R2如上所定义。

    Process for preparing azetidinone derivatives
    10.
    发明授权
    Process for preparing azetidinone derivatives 失效
    制备氮杂环丁酮衍生物的方法

    公开(公告)号：US4566996A

    公开(公告)日：1986-01-28

    申请号：US567736

    申请日：1984-01-03

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Takashi Shiroi ,  Michio Sasaoka ,  Norio Saito ,  Kiyotoshi Matsumura

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Takashi Shiroi ,  Michio Sasaoka ,  Norio Saito ,  Kiyotoshi Matsumura

    IPC分类号： C07D205/08 ,  C07D205/095 ,  C07D405/12

    CPC分类号： C07D205/095 ,  Y02P20/55

    摘要： A process for preparing an azetidinone derivative represented by the formula (1) ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted phenylmethyl group or a substituted or unsubstituted phenoxymethyl group, R.sup.2 represents a hydrogen atom or a group for protecting carboxylic acid and Ar represents a substituted or unsubstituted phenyl group, the process comprising reacting a thiazolineazetidinone derivative represented by the formula (2) ##STR2## wherein R.sup.1 and R.sup.2 are as defined above with a sulfonyl bromide represented by the formula (3)Ar--SO.sub.2 --Br (3)wherein Ar is as defined above in water-containing organic solvent.

    摘要翻译： 制备由式（1）表示的氮杂环丁酮衍生物的方法其中R1表示取代或未取代的芳基，取代或未取代的苯基甲基或取代或未取代的苯氧基甲基，R2表示氢原子或 用于保护羧酸和Ar的基团代表取代或未取代的苯基，该方法包括使式（2）表示的噻唑啉氮杂环丁酮衍生物（2）其中R1和R2如上定义， 式（3）Ar-SO 2-Br（3）其中Ar如上所述在含水有机溶剂中。