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54 条记录 (耗时 0.079 秒)

    Process for preparing 2,2-bishalomethylpenam derivatives
    1.
    发明授权
    Process for preparing 2,2-bishalomethylpenam derivatives 失效
    2,2-二油基甲基衍生物的制备方法

    公开(公告)号：US4599151A

    公开(公告)日：1986-07-08

    申请号：US711922

    申请日：1985-03-15

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Takashi Shiroi ,  Seiryu Uto

    IPC分类号： C25B3/04 ,  C07D499/00 ,  C07D499/06 ,  C07D499/44 ,  C25B3/00 ,  C25B3/06

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： This invention provides a process for preparing a 2,2-bishalomethylpenam derivative represented by the formula ##STR1## wherein R.sup.1 represents a lower alkyl group, aryl group, arylmethyl group, arylcarbonyl group or aryloxymethyl group, R.sup.2 represents a carboxyl-protecting group, X.sup.1 and X.sup.2 are the same or different and represent a halogen atom, the process being characterized in that a disulfide represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and X.sup.1 are as defined above and R.sup.3 represents an aryl group or heterocyclic group is subjected to an electrolytic reaction in a solvent in the presence of a halogen acid and/or halogen salt.

    摘要翻译： 本发明提供一种制备式（I）表示的2,2-二油基甲基联苯胺衍生物的方法，其中R1表示低级烷基，芳基，芳基甲基，芳基羰基或芳氧基甲基，R2表示羧基保护基 基团，X1和X2相同或不同，表示卤素原子，该方法的特征在于由式（II）表示的二硫化物，其中R 1，R 2和X 1如上所定义，R 3表示芳基 或杂环基在卤素酸和/或卤素盐的存在下在溶剂中进行电解反应。

    Process for preparing thiosulfonate derivatives
    2.
    发明授权
    Process for preparing thiosulfonate derivatives 失效
    硫代磺酸衍生物的制备方法

    公开(公告)号：US4609438A

    公开(公告)日：1986-09-02

    申请号：US673309

    申请日：1984-11-20

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Yutaka Kameyama

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Yutaka Kameyama

    IPC分类号： C25B3/10 ,  C07D277/78 ,  C25B3/00

    CPC分类号： C07D277/78 ,  C25B3/00

    摘要： This invention provides a process for preparing a thiosulfonate derivative represented by the formulaR.sup.2 SO.sub.2 SR.sup.1 (III)wherein R.sup.1 is substituted or unsubstituted 2-benzothiazolyl, and R.sup.2 is substituted or unsubstituted phenyl, the process being characterized in that a compound represented by the formulaR.sup.1 SX (I)wherein R.sup.1 is as defined above, and X is hydrogen, alkali metal or SR.sup.1, and a sulfinic acid or a salt thereof represented by the formulaR.sup.2 SO.sub.2 Y (II)wherein R.sup.2 is as defined above, and Y is a hydrogen atom, alkali metal atom, alkaline earth metal atom or quaternary ammonium are subjected to an electrolytic reaction in a mixture of water and an organic solvent in the presence of a halogen salt.

    摘要翻译： 本发明提供一种制备由式R 2 SO 2 S R 1（III）表示的硫代磺酸酯衍生物的方法，其中R 1为取代或未取代的2-苯并噻唑基，R 2为取代或未取代的苯基，该方法的特征在于式R1SX I）其中R1如上所定义，X是氢，碱金属或SR1，以及由式R2SO2Y（Ⅱ）表示的亚磺酸或其盐，其中R2如上定义，Y是氢原子，碱 金属原子，碱土金属原子或季铵在卤素盐存在下，在水和有机溶剂的混合物中进行电解反应。

    Process for preparation of azetidinone derivatives
    3.
    发明授权
    Process for preparation of azetidinone derivatives 失效
    氮杂环丁酮衍生物的制备方法

    公开(公告)号：US4713452A

    公开(公告)日：1987-12-15

    申请号：US680723

    申请日：1984-12-12

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Syozo Hayase

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Syozo Hayase

    IPC分类号： C07D205/08 ,  A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  C07D205/09 ,  C07D205/095 ,  C07D417/12 ,  C07B45/00 ,  C07F7/10 ,  C07F9/65

    CPC分类号： C07D205/09 ,  C07D205/095

    摘要： A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formulaR.sup.3 SO.sub.2 CN (VII)wherein R.sup.3 is defined above.

    摘要翻译： 制备式（I）表示的氮杂环丁酮衍生物的方法，其中R 1是氢，卤素或低级烷氧基，R 2是氢，卤素，低级烷氧基，氨基或基团（其中R 5是取代的或 未取代的苯基，取代或未取代的苯基甲基，取代或未取代的苯氧基甲基或取代或未取代的苯甲酰基），或R 1和R 2一起为羰基，R 3为取代或未取代的苯基，且R 4为氢，任选取代的烃残基或酰基 ，衍生自无机酸或有机酸的甲硅烷基，磺酰基或膦酰基，该方法包括使由式（VI）表示的二硫代氮杂环丁酮衍生物（其中R 1，R 2和R 4如上所定义）和R 9是取代或未取代的， 含有由式R 3 SO 2 CN（Ⅶ）表示的化合物的芳族杂环残基，其中R 3如上定义。

    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative
    4.
    发明授权
    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative 失效
    制备噻唑基氮杂环丁酮和2-外 - 亚甲基台am am嗪衍生物的方法

    公开(公告)号：US5288860A

    公开(公告)日：1994-02-22

    申请号：US3024

    申请日：1993-01-11

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/12 ,  C07D499/87 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D499/00 ,  Y02P20/55

    摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

    摘要翻译： 本发明提供由式（1）表示的噻唑并氮杂环丁酮衍生物，其中R 1是具有或不具有取代基的苯基，具有或不具有取代基的甲基或基团，R3是具有或不具有取代基的苯基， 不具有取代基，R2为氢原子或羧酸保护基，及其制备方法。 本发明进一步提供了制备2-异亚甲基台内叶酸衍生物的方法，其特征在于水解上述式（1）的噻唑并氮杂环丁酮衍生物的噻唑啉环以进行再循环，得到式（1）所示的2-外 - 亚甲基山梨醇衍生物， 图像（3）其中R1和R2如上所定义。