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公开(公告)号：US20100158877A1
公开(公告)日：2010-06-24
申请号：US12642774
申请日：2009-12-19
摘要： Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.
摘要翻译： 使用衍生自脐带组织的细胞刺激和支持肺组织血管发生，改善肺组织的血液流动，再生，修复和改善肺部疾病，障碍和/或损伤损伤的肺组织的组合物和方法，并且保护 肺组织由患有肺部疾病，病症和/或损伤引起的损伤。
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52.发明申请REPAIR AND REGENERATION OF RENAL TISSUE USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 有权使用人脐带组织细胞的肾组织修复和再生公开(公告)号：US20090092653A1
公开(公告)日：2009-04-09
申请号：US12245571
申请日：2008-10-03
申请人： David C. COLTER , Anna Gosiewska
发明人： David C. COLTER , Anna Gosiewska
CPC分类号： A61K35/44 , A61K35/12 , C12N5/0605
摘要： Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有至少一种肾脏疾病或损伤的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 当施用时，细胞促进并支持患者中患病或损坏的肾组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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公开(公告)号：US20090004253A1
公开(公告)日：2009-01-01
申请号：US11824517
申请日：2007-06-29
摘要： The present invention is directed to composite devices comprising a tissue-engineering scaffold and an anionic polysaccharide/structural protein coating. The composite devices are useful for the reparation and regeneration of tissue, particularly in the treatment of chronic wounds.
摘要翻译： 本发明涉及包含组织工程支架和阴离子多糖/结构蛋白质涂层的复合装置。 复合装置可用于组织的修复和再生，特别是用于治疗慢性伤口。
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54.发明授权Mammary artery derived cells and methods of use in tissue repair and regeneration 有权乳腺动脉来源的细胞和组织修复和再生中使用的方法公开(公告)号：US08323972B2
公开(公告)日：2012-12-04
申请号：US12885855
申请日：2010-09-20
CPC分类号： C12N5/069 , C12N5/0668 , C12N5/0692 , C12N2509/00
摘要： An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.
摘要翻译： 公开了一种分离的哺乳动物内部乳腺动脉来源的细胞。 此外，公开了分离哺乳动物内部乳腺动脉的细胞的方法。 该细胞可用于组织工程技术，特别是在血管组织工程中。
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55.发明申请MAMMARY ARTERY DERIVED CELLS AND METHODS OF USE IN TISSUE REPAIR AND REGENERATION 有权主动脉导管细胞和组织修复和再生中使用的方法公开(公告)号：US20110076769A1
公开(公告)日：2011-03-31
申请号：US12885855
申请日：2010-09-20
IPC分类号： C12N5/071
CPC分类号： C12N5/069 , C12N5/0668 , C12N5/0692 , C12N2509/00
摘要： An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.
摘要翻译： 公开了一种分离的哺乳动物内部乳腺动脉来源的细胞。 此外，公开了分离哺乳动物内部乳腺动脉的细胞的方法。 该细胞可用于组织工程技术，特别是在血管组织工程中。
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公开(公告)号：US20100158880A1
公开(公告)日：2010-06-24
申请号：US12642773
申请日：2009-12-19
申请人： Agnieszka Seyda , Anna Gosiewska
发明人： Agnieszka Seyda , Anna Gosiewska
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0668
摘要： Methods, pharmaceutical compositions and kits for regenerating or repairing neural tissue, decreasing apoptosis and improving neurological function following injury are disclosed.
摘要翻译： 公开了用于再生或修复神经组织的药物组合物和试剂盒，减少细胞凋亡并改善损伤后的神经功能。
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57.发明申请公开(公告)号：US20090169597A1
公开(公告)日：2009-07-02
申请号：US12337439
申请日：2008-12-17
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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58.发明申请Human Umbilical Tissue-Derived Cell Compositions for the Treatment of Incontinence 审中-公开用于治疗失禁的人脐带组织衍生的细胞组合物公开(公告)号：US20080311087A1
公开(公告)日：2008-12-18
申请号：US12133792
申请日：2008-06-05
CPC分类号： A61K35/44 , A61K9/0019 , A61K47/34
摘要： Compositions for the treatment of incontinence are disclosed. More particularly, compositions of human umbilical tissue-derived cells and a carrier are disclosed. The compositions are useful in the treatment urinary and fecal incontinence.
摘要翻译： 公开了治疗失禁的组合物。 更具体地，公开了人脐带组织衍生细胞和载体的组合物。 该组合物可用于治疗尿失禁和大便失禁。
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公开(公告)号：US06783953B1
公开(公告)日：2004-08-31
申请号：US09468647
申请日：1999-12-21
申请人： Robert D. Gordon , Jörg J. Sprengel , Jeffrey R. Yon , Josiena J. H. Dijkmans , Anna Gosiewska , Sridevi N. Dhanaraj , Jean Xu
发明人： Robert D. Gordon , Jörg J. Sprengel , Jeffrey R. Yon , Josiena J. H. Dijkmans , Anna Gosiewska , Sridevi N. Dhanaraj , Jean Xu
IPC分类号： C12P2106
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.
摘要翻译： 除了编码它的核酸分子，用所述载体转化的宿主细胞和抑制或增强血管发生的化合物之外，还提供了新颖的血管内皮生长因子，其被称为VEGF-X。 还提供了存在于VEGF-X序列中的CUB结构域本身防止血管生成并用于治疗与不适当血管形成或血管发生相关的疾病的序列。
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公开(公告)号：US10557116B2
公开(公告)日：2020-02-11
申请号：US12642774
申请日：2009-12-19
摘要： Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.
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