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    Cyclic compound having pyrimidinylalkylthio group
    52.
    发明授权
    Cyclic compound having pyrimidinylalkylthio group 有权
    具有嘧啶基烷硫基的环状化合物

    公开(公告)号：US07906511B2

    公开(公告)日：2011-03-15

    申请号：US11887308

    申请日：2006-03-31

    申请人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    发明人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K31/5377

    CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/12 ,  C07D409/12

    摘要： The present invention has its object to study synthesis of novel cyclic compounds having a pyrimidinylalkylthio group and to find pharmacological actions of the compounds. According to the present invention, a compound represented by the formula (1) or a salt thereof is provided. In the formula, the ring X represents: R1 and R2 independently represent a hydrogen atom, an alkyl group, an aryl group, an aromatic heterocyclic group or the like; R3 represents a hydrogen atom, a halogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino group or the like; A1 represents a sulfur atom or the like; and A2 represents an alkylene group.

    摘要翻译： 本发明的目的是研究具有嘧啶基烷硫基的新型环状化合物的合成，并找到化合物的药理作用。 根据本发明，提供由式（1）表示的化合物或其盐。 在该式中，环X表示：R 1和R 2分别表示氢原子，烷基，芳基，芳香族杂环基等， R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基等; A1表示硫原子等; A2表示亚烷基。

    NOVEL OXADIAZOLE DERIVATIVES AND THIADIAZOLE DERIVATIVES HAVING NEOVASCULARIZATION INHIBITORY ACTIVITY
    53.
    发明申请
    NOVEL OXADIAZOLE DERIVATIVES AND THIADIAZOLE DERIVATIVES HAVING NEOVASCULARIZATION INHIBITORY ACTIVITY 失效
    新型氧化氮衍生物和具有新鲜血液活性抑制活性的噻唑衍生物

    公开(公告)号：US20100016354A1

    公开(公告)日：2010-01-21

    申请号：US12449159

    申请日：2008-01-29

    申请人： Takahiro Honda ,  Koushi Fujisawa ,  Hiroyuki Aono ,  Masakazu Ban

    发明人： Takahiro Honda ,  Koushi Fujisawa ,  Hiroyuki Aono ,  Masakazu Ban

    IPC分类号： A61K31/4725 ,  C07D413/12 ,  A61K31/4439 ,  C07D413/14 ,  A61K31/444 ,  A61P35/00 ,  A61P3/10 ,  A61P19/02

    CPC分类号： C07D285/135 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Ra represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; the ring B represents a pyridine ring, a pyrimidine ring, or a quinoline ring; the ring C represents a benzene ring; a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y, the same or different, represent an oxygen atom or a sulfur atom, with the proviso that the case X is a sulfur atom and Y is an oxygen atom be excluded; R1 represents a hydrogen atom, a halogen atom, an amino group, a cycloalkylamino group, an alkylcarbonylamino group, an alkyloxycarbonylamino group, an alkylaminocarbonyl group, or a non-aromatic heterocyclic group; and R2 and R2′, the same or different, represent a hydrogen atom, a halogen atom, an alkyl group, a halogeno-alkyl group, or a halogeno-alkoxy group.

    摘要翻译： 本发明涉及由式（I）表示的化合物或其盐。 在式（I）中，环A表示苯环，噻吩环或吡啶环; Ra表示氢原子，卤素原子，烷基或烷氧基; 环B表示吡啶环，嘧啶环或喹啉环; 环C表示苯环; 吡啶环，喹啉环或异喹啉环; X和Y相同或不同，表示氧原子或硫原子，条件是情况X为硫原子，Y为氧原子排除; R1表示氢原子，卤素原子，氨基，环烷基氨基，烷基羰基氨基，烷氧基羰基氨基，烷基氨基羰基或非芳香族杂环基; 和R2和R2'相同或不同，表示氢原子，卤素原子，烷基，卤代烷基或卤代 - 烷氧基。

    METHOD FOR PRODUCING TONER, AND TONER
    54.
    发明申请
    METHOD FOR PRODUCING TONER, AND TONER 审中-公开
    生产墨粉和墨粉的方法

    公开(公告)号：US20090239170A1

    公开(公告)日：2009-09-24

    申请号：US12405741

    申请日：2009-03-17

    申请人： Takahiro Honda ,  Yohichiroh Watanabe ,  Kazumi Suzuki ,  Shinji Ohtani ,  Yoshihiro Norikane

    发明人： Takahiro Honda ,  Yohichiroh Watanabe ,  Kazumi Suzuki ,  Shinji Ohtani ,  Yoshihiro Norikane

    IPC分类号： G03G9/087 ,  G03G9/08

    CPC分类号： G03G9/0804 ,  G03G9/0819 ,  G03G9/08782

    摘要： A method for producing a toner, the method including discharging a toner composition liquid from a plurality of nozzles to form liquid droplets thereof, the toner composition liquid being prepared by dissolving or dispersing in a solvent a toner composition containing at least a binder resin, a colorant, an acid-modified hydrocarbon wax and an unmodified hydrocarbon wax, the waxes serving as a releasing agent, and solidifying the liquid droplets so as to form solid particles.

    摘要翻译： 一种调色剂的制造方法，该方法包括从多个喷嘴排出调色剂组合物液体以形成液滴，所述调色剂组合物液体通过将溶解或分散在溶剂中而制备，所述调色剂组合物至少含有粘合剂树脂， 着色剂，酸改性烃蜡和未改性烃蜡，所述蜡用作脱模剂，并固化液滴以形成固体颗粒。

    Compounds having 4-pyridylalkylthio group as substituent
    55.
    发明授权
    Compounds having 4-pyridylalkylthio group as substituent 有权
    具有4-吡啶基烷硫基作为取代基的化合物

    公开(公告)号：US07534802B2

    公开(公告)日：2009-05-19

    申请号：US10548283

    申请日：2004-03-05

    申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

    发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

    IPC分类号： C07D401/14 ,  A61K31/444

    CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

    摘要： A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R1 and R2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

    摘要翻译： 本发明的目的是提供一种新颖的具有4-吡啶基烷硫基作为取代基的五元或六元杂环衍生物或其盐，其可用作药物。 由以下通式[I]表示的化合物或其盐可用作涉及血管生成或增加血管通透性的疾病的治疗剂。 在该式中，环“A”是可以与环烷烃环稠合的苯环或芳族五元或六元杂环，“B”是亚烷基，R 1和R 2相同或不同，是H，OH 取代或未取代的烷氧基等，X和Y相同或不同，分别为选自H，卤素，OH，取代或未取代的烷氧基等的基团，p为0,1或2，q为0,1或2，q为 是0或1。

    Image forming method and apparatus, and developing device and process cartridge therefor
    56.
    发明申请
    Image forming method and apparatus, and developing device and process cartridge therefor 有权
    图像形成方法和装置，以及显影装置和处理盒

    公开(公告)号：US20060245794A1

    公开(公告)日：2006-11-02

    申请号：US11407368

    申请日：2006-04-20

    申请人： Takahiro Honda ,  Hiroyuki Fushimi ,  Shuuichi Endoh ,  Masato Iio ,  Shinya Tanaka

    发明人： Takahiro Honda ,  Hiroyuki Fushimi ,  Shuuichi Endoh ,  Masato Iio ,  Shinya Tanaka

    IPC分类号： G03G15/08

    CPC分类号： G03G15/0896 ,  G03G2215/0822

    摘要： An image forming apparatus including an image bearing member and a developing device configured to develop an electrostatic image on the image bearing member with a toner to form a toner image thereon and including a developing unit configured to develop the electrostatic image, and a toner cartridge configured to supply the toner to the developing unit through at least one opening, wherein the developing device circulates the toner between the toner cartridge and the developing unit through the at least one opening, and wherein the internal temperature of the hopper is higher than that of the cartridge and the ratio of a charge quantity distribution parameter of the toner under a condition of 45° C. and 54% RH to that under a condition of 25° C. and 54% RH is greater than 0.9 and less than 1.5.

    摘要翻译： 一种图像形成装置，包括图像承载部件和显影装置，该显影装置被配置为利用调色剂在图像承载部件上显影静电图像以在其上形成调色剂图像，并且包括构造成使静电图像显影的显影单元和配置成 通过至少一个开口将调色剂供应到显影单元，其中显影装置通过至少一个开口使调色剂盒和显影单元之间的调色剂循环，并且其中料斗的内部温度高于 在45℃和54％RH的条件下，调色剂的电荷量分布参数与在25℃和54％RH的条件下的电荷量分布参数之比大于0.9且小于1.5。

    Image forming apparatus and image forming method
    57.
    发明授权
    Image forming apparatus and image forming method 有权

    公开(公告)号：US11592768B2

    公开(公告)日：2023-02-28

    申请号：US17743449

    申请日：2022-05-13

    申请人： Takahiro Honda ,  Yasuo Kamada ,  Hiroshi Yamada

    发明人： Takahiro Honda ,  Yasuo Kamada ,  Hiroshi Yamada

    IPC分类号： G03G15/00 ,  G03G15/01 ,  G03G15/16

    摘要： An image forming apparatus includes an image bearer, a developing unit configured to develop a latent image formed on the image bearer with a toner to form a toner image, and a transfer member including a contact area that comes in contact with the image bearer. The toner image is primary transferred from the image bearer to the transfer member. A speed difference between the image bearer and the transfer member at the contact area is 0.1% or greater but 0.8% or less. The toner has an average circularity of 0.971 or greater but 0.986 or less and a shape factor SF-2 of 110 or greater but 119 or less. The speed difference is represented by the following formula: Speed difference [%]={(V1−V2)/V2}×100  [Speed difference] where V1 is a linear speed of the image bearer, and V2 is a linear speed of the transfer member.

    Method and apparatus for producing toner
    58.
    发明授权
    Method and apparatus for producing toner 有权
    用于生产调色剂的方法和设备

    公开(公告)号：US08748072B2

    公开(公告)日：2014-06-10

    申请号：US12488843

    申请日：2009-06-22

    申请人： Takahiro Honda ,  Yukio Tabata ,  Yohichiroh Watanabe ,  Kazumi Suzuki ,  Shinji Ohtani ,  Yoshihiro Norikane

    发明人： Takahiro Honda ,  Yukio Tabata ,  Yohichiroh Watanabe ,  Kazumi Suzuki ,  Shinji Ohtani ,  Yoshihiro Norikane

    IPC分类号： G03G5/00

    CPC分类号： G03G9/0804 ,  G03G9/1136

    摘要： A method for producing a toner, including ejecting a toner composition liquid containing at least a resin and a colorant periodically from a plurality of nozzles into a chamber using a vibration unit, so as to form droplets in a gas phase; and solidifying the droplets, wherein the droplets are transported by transport air flow selected from at least one of vertical downward air flow and rotational air flow, and the method can prevent toner particles from aggregation.

    摘要翻译： 一种制造调色剂的方法，包括使用振动单元将从多个喷嘴周期性地至少含有树脂和着色剂的调色剂组合物液体周期性地喷射到室中，以便在气相中形成液滴; 并固化液滴，其中液滴由选自垂直向下空气流和旋转空气流中的至少一种的输送空气流输送，并且该方法可以防止调色剂颗粒聚集。

    Cyclic compound having pyrimidinylalkylthio group
    59.
    发明授权
    Cyclic compound having pyrimidinylalkylthio group 有权
    具有嘧啶基烷硫基的环状化合物

    公开(公告)号：US08507485B2

    公开(公告)日：2013-08-13

    申请号：US12931072

    申请日：2011-01-24

    申请人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    发明人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    IPC分类号： A61K31/5377 ,  A61K31/506

    CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/12 ,  C07D409/12

    摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.

    摘要翻译： 通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或 芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基 芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。