公开(公告)号：US08039486B2

公开(公告)日：2011-10-18

申请号：US12028189

申请日：2008-02-08

申请人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J. J. Kim Wright

发明人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J. J. Kim Wright

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

摘要翻译： 本发明提供具有药物和生物影响性质的式I化合物，包括其药学上可接受的盐，其药物组合物和使用方法。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。 式I的化合物具有下式：其中：Z为Q选自m为2; A选自噌啉基，萘啶基，喹喔啉基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹唑啉基，氮杂苯并呋喃基和酞嗪基，其各自可以任选被一个或两个独立地选自甲基，甲氧基，羟基，氨基 和卤素; 和-W-是

公开(公告)号：US07902204B2

公开(公告)日：2011-03-08

申请号：US12026633

申请日：2008-02-06

申请人： John A. Bender ,  Zhong Yang ,  John F. Kadow ,  Nicholas A. Meanwell

发明人： John A. Bender ,  Zhong Yang ,  John F. Kadow ,  Nicholas A. Meanwell

IPC分类号： A61K31/519 ,  C07D239/40 ,  A01N43/90

CPC分类号： C07D487/04

摘要： The invention comprises substituted diazaindole-dicarbonyl-piperazinyl derivatives of general Formula I wherein: Q is selected from the group consisting of -- may represent a bond; T is —C(O)— or —CH(CN)—; and —Y— is selected from the group consisting of compositions thereof and their use for treating HIV infection.

摘要翻译： 本发明包括通式I的取代二氮杂双 - 二羰基 - 哌嗪衍生物，其中：Q选自 - 可以表示键; T是-C（O） - 或-CH（CN） - ; 和-Y-选自其组合物及其用于治疗HIV感染的用途。

公开(公告)号：US07399758B2

公开(公告)日：2008-07-15

申请号：US11507731

申请日：2006-08-22

申请人： Nicholas A. Meanwell ,  Robert G. Gentles ,  Min Ding ,  John A. Bender ,  John F. Kadow ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  Xiaofan Zheng

发明人： Nicholas A. Meanwell ,  Robert G. Gentles ,  Min Ding ,  John A. Bender ,  John F. Kadow ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  Xiaofan Zheng

IPC分类号： A61P31/00 ,  A61K31/55 ,  C07D223/14

CPC分类号： C07D487/04

摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20110077280A1

公开(公告)日：2011-03-31

申请号：US12729940

申请日：2010-03-23

申请人： John A. Bender ,  Piyasena Hewawasam ,  John F. Kadow ,  Omar D. Lopez ,  Nicholas A. Meanwell ,  Van N. Nguyen ,  Jeffrey Lee Romine ,  Lawrence B. Snyder ,  Denis R. St. Laurent ,  Gan Wang ,  Ningning Xu ,  Makonen Belema

发明人： John A. Bender ,  Piyasena Hewawasam ,  John F. Kadow ,  Omar D. Lopez ,  Nicholas A. Meanwell ,  Van N. Nguyen ,  Jeffrey Lee Romine ,  Lawrence B. Snyder ,  Denis R. St. Laurent ,  Gan Wang ,  Ningning Xu ,  Makonen Belema

IPC分类号： A61K31/4178 ,  C07D403/14 ,  A61K31/4184 ,  C07D405/14 ,  A61P31/14

CPC分类号： C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

公开(公告)号：US08796466B2

公开(公告)日：2014-08-05

申请号：US12729940

申请日：2010-03-23

申请人： John A. Bender ,  Piyasena Hewawasam ,  John F. Kadow ,  Omar D. Lopez ,  Nicholas A. Meanwell ,  Van N. Nguyen ,  Jeffrey Lee Romine ,  Lawrence B. Snyder ,  Denis R. St. Laurent ,  Gan Wang ,  Ningning Xu ,  Makonen Belema

发明人： John A. Bender ,  Piyasena Hewawasam ,  John F. Kadow ,  Omar D. Lopez ,  Nicholas A. Meanwell ,  Van N. Nguyen ,  Jeffrey Lee Romine ,  Lawrence B. Snyder ,  Denis R. St. Laurent ,  Gan Wang ,  Ningning Xu ,  Makonen Belema

IPC分类号： A61K31/4178 ,  A61K31/4184 ,  A61P31/14 ,  C07D403/14 ,  C07D405/14

CPC分类号： C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

公开(公告)号：US20130121957A1

公开(公告)日：2013-05-16

申请号：US13465298

申请日：2012-05-07

申请人： Qi Chen ,  Omar D. Lopez ,  John A. Bender ,  Gan Wang ,  Van N. Nguyen ,  John F. Kadow ,  Nicholas A. Meanwell ,  Makonen Belema

发明人： Qi Chen ,  Omar D. Lopez ,  John A. Bender ,  Gan Wang ,  Van N. Nguyen ,  John F. Kadow ,  Nicholas A. Meanwell ,  Makonen Belema

IPC分类号： C07D403/14 ,  A61K45/06 ,  A61K31/4184 ,  A61K31/5377 ,  A61K31/4178 ,  C07D405/14

CPC分类号： C07D403/14 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：US20080125439A1

公开(公告)日：2008-05-29

申请号：US12026633

申请日：2008-02-06

申请人： John A. Bender ,  Zhong Yang ,  John F. Kadow ,  Nicholas A. Meanwell

发明人： John A. Bender ,  Zhong Yang ,  John F. Kadow ,  Nicholas A. Meanwell

IPC分类号： A61K31/497 ,  C07D487/04 ,  A61P31/18

CPC分类号： C07D487/04

摘要： The invention comprises substituted diazaindole-dicarbonyl-piperazinyl derivatives of general Formula I wherein: Q is selected from the group consisting of -- may represent a bond; T is —C(O)— or —CH(CN)—; and —Y— is selected from the group consisting of compositions thereof and their use for treating HIV infection.

摘要翻译： 本发明包括通式I的取代二氮杂双 - 二羰基 - 哌嗪衍生物，其中：Q选自 - 可以表示键; T是-C（O） - 或-CH（CN） - ; 和-Y-选自其组合物及其用于治疗HIV感染的用途。

公开(公告)号：US08552047B2

公开(公告)日：2013-10-08

申请号：US13361541

申请日：2012-01-30

申请人： John A. Bender ,  Omar D. Lopez ,  Gan Wang ,  Makonen Belema ,  John F. Kadow

发明人： John A. Bender ,  Omar D. Lopez ,  Gan Wang ,  Makonen Belema ,  John F. Kadow

IPC分类号： A01N43/50 ,  A61K31/415 ,  C07D403/02

CPC分类号： C07D309/06 ,  A61K31/4178 ,  A61K45/06 ,  C07D405/14 ,  A61K2300/00

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：US08309558B2

公开(公告)日：2012-11-13

申请号：US13371786

申请日：2012-02-13

申请人： Kap-Sun Yeung ,  Kyle E. Parcella ,  John A. Bender ,  Brett R. Beno ,  Katharine A. Grant-Young ,  Ying Han ,  Piyasena Hewawasam ,  John F. Kadow ,  Andrew Nickel

发明人： Kap-Sun Yeung ,  Kyle E. Parcella ,  John A. Bender ,  Brett R. Beno ,  Katharine A. Grant-Young ,  Ying Han ,  Piyasena Hewawasam ,  John F. Kadow ,  Andrew Nickel

IPC分类号： A61K31/506 ,  C07D405/02

CPC分类号： A61K31/506 ,  A61K45/06 ,  C07D307/84 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D453/00 ,  C07D491/10

摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US20110020275A1

公开(公告)日：2011-01-27

申请号：US12922722

申请日：2009-03-25

申请人： Kap-Sun Yeung ,  Ying Han ,  John F. Kadow

发明人： Kap-Sun Yeung ,  Ying Han ,  John F. Kadow

IPC分类号： A61K38/20 ,  C07D487/04 ,  A61K31/55 ,  A61K38/21 ,  A61K38/13 ,  A61P31/14

CPC分类号： C07D487/04

摘要： The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

摘要翻译： 本公开提供式（I）化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。