公开(公告)号：US08039486B2

公开(公告)日：2011-10-18

申请号：US12028189

申请日：2008-02-08

申请人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J. J. Kim Wright

发明人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J. J. Kim Wright

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

摘要翻译： 本发明提供具有药物和生物影响性质的式I化合物，包括其药学上可接受的盐，其药物组合物和使用方法。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。 式I的化合物具有下式：其中：Z为Q选自m为2; A选自噌啉基，萘啶基，喹喔啉基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹唑啉基，氮杂苯并呋喃基和酞嗪基，其各自可以任选被一个或两个独立地选自甲基，甲氧基，羟基，氨基 和卤素; 和-W-是

公开(公告)号：US20080132516A1

公开(公告)日：2008-06-05

申请号：US12028189

申请日：2008-02-08

申请人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J.J Kim Wright

发明人： Kap-Sun Yeung ,  Michelle E. Farkas ,  John F. Kadow ,  Nicholas A. Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Stephen Coulter ,  J.J Kim Wright

IPC分类号： A61K31/496 ,  C07D401/14 ,  A61P31/18

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

摘要翻译： 本发明提供具有药物和生物影响性质的式I化合物，包括其药学上可接受的盐，其药物组合物和使用方法。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。 式I的化合物具有下式：其中：Z为Q选自m为2; A选自噌啉基，萘啶基，喹喔啉基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹唑啉基，氮杂苯并呋喃基和酞嗪基，其各自可以任选被一个或两个独立地选自甲基，甲氧基，羟基，氨基 和卤素; 和-W-是

公开(公告)号：US20050261296A1

公开(公告)日：2005-11-24

申请号：US11029673

申请日：2005-01-05

申请人： Kap-Sun Yeung ,  Michelle Farkas ,  John Kadow ,  Nicholas Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Coulter ,  J. Wright

发明人： Kap-Sun Yeung ,  Michelle Farkas ,  John Kadow ,  Nicholas Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Coulter ,  J. Wright

IPC分类号： A61K31/405 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/502 ,  A61K31/517 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D43/14

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides compounds of Formula I, including pharmaceutically accceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

摘要翻译： 本发明提供具有药物和生物影响性质的式I化合物，包括其药学上可接受的盐，其药物组合物和使用方法。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。 式I的化合物具有下式：其中：Z为Q选自m为2; A选自噌啉基，萘啶基，喹喔啉基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹唑啉基，氮杂苯并呋喃基和酞嗪基，其各自可以任选被一个或两个独立地选自甲基，甲氧基，羟基，氨基 和卤素; 和-W-是

公开(公告)号：US20050075364A1

公开(公告)日：2005-04-07

申请号：US10871931

申请日：2004-06-18

申请人： Kap-Sun Yeung ,  Michelle Farkas ,  John Kadow ,  Nicholas Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Coulter ,  J. J. Wright

发明人： Kap-Sun Yeung ,  Michelle Farkas ,  John Kadow ,  Nicholas Meanwell ,  Malcolm Taylor ,  David Johnston ,  Thomas Coulter ,  J. J. Wright

IPC分类号： A61K31/405 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/502 ,  A61K31/517 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides compounds of Formula I, including pharmaceutically accceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

公开(公告)号：US09609284B2

公开(公告)日：2017-03-28

申请号：US13830665

申请日：2013-03-14

申请人： Julian Michael Urbach ,  Malcolm Taylor ,  Clay Sparks ,  Timothy Hawkins

发明人： Julian Michael Urbach ,  Malcolm Taylor ,  Clay Sparks ,  Timothy Hawkins

IPC分类号： H04N7/18 ,  G05D1/00 ,  G05D1/10

CPC分类号： H04N7/181 ,  G05D1/0094 ,  G05D1/104

摘要： A subject is imaged using imaging equipment arranged on portable, wireless vehicles. The vehicles are positioned in a pattern in proximity to the subject and illuminate the subject in order to collect image data. The image data can be collected by cameras carried by the vehicles in addition to or instead of external high speed cameras.

公开(公告)号：US20130314502A1

公开(公告)日：2013-11-28

申请号：US13830665

申请日：2013-03-14

申请人： Julian Michael Urbach ,  Malcolm Taylor ,  Clay Sparks ,  Timothy Hawkins

发明人： Julian Michael Urbach ,  Malcolm Taylor ,  Clay Sparks ,  Timothy Hawkins

IPC分类号： H04N7/18

CPC分类号： H04N7/181 ,  G05D1/0094 ,  G05D1/104

摘要： A subject is imaged using imaging equipment arranged on portable, wireless vehicles. The vehicles are positioned in a pattern in proximity to the subject and illuminate the subject in order to collect image data. The image data can be collected by cameras carried by the vehicles in addition to or instead of external high speed cameras.

摘要翻译： 使用布置在便携式无线车辆上的成像设备对被摄体进行成像。 车辆定位在靠近被摄体的图案中并照亮被摄体以便收集图像数据。 图像数据可以由除了外部高速摄像机之外的车辆或由外部高速摄像机代替的车辆携带的摄像机来收集。

公开(公告)号：US20050077225A1

公开(公告)日：2005-04-14

申请号：US10684215

申请日：2003-10-10

申请人： Kathryn Usher ,  George Foster ,  Edward Kolvek ,  Andrew Harvey ,  Malcolm Taylor ,  Thomas Lovell ,  Colin Hart ,  William Girzone

发明人： Kathryn Usher ,  George Foster ,  Edward Kolvek ,  Andrew Harvey ,  Malcolm Taylor ,  Thomas Lovell ,  Colin Hart ,  William Girzone

IPC分类号： A61M5/14 ,  A61M5/165 ,  A61M5/36 ,  A61M5/38 ,  B01D19/00 ,  B01D61/00 ,  B01D63/10 ,  B01D63/14 ,  C02F1/44

CPC分类号： B01D63/10 ,  A61M5/1408 ,  A61M5/36 ,  A61M5/385 ,  A61M2005/1657 ,  A61M2205/7527 ,  A61M2205/7536 ,  B01D19/0031 ,  B01D61/00 ,  B01D63/14 ,  B01D2313/18

摘要： Medical devices for removing gasses, such as gas bubbles and/or dissolved gasses, from a liquid to be delivered to a patient, and methods of use and making of such devices. In at least some embodiments, a gas permeable membrane material is used in the construction of the gas removal devices. In some embodiments, layers of gas permeable membrane material are used to construct a filter structure for removing gas from the liquid. In other embodiments, hollow tubes and/or fibers of the gas permeable membrane material are used to construct a filter structure for removing gas from the liquid. The gas removal devices may be used in any of a broad variety of liquid delivery systems and/or configurations.

摘要翻译： 用于从待输送到患者的液体中除去诸如气泡和/或溶解气体的气体的医疗装置，以及使用和制造这种装置的方法。 在至少一些实施例中，在气体去除装置的构造中使用透气膜材料。 在一些实施例中，使用透气膜材料层来构建用于从液体中除去气体的过滤器结构。 在其他实施例中，气体可渗透膜材料的中空管和/或纤维用于构建用于从液体中除去气体的过滤器结构。 气体去除装置可以用于各种各样的液体输送系统和/或构造中的任何一种。

公开(公告)号：US20070142399A1

公开(公告)日：2007-06-21

申请号：US10561784

申请日：2004-06-21

申请人： Charles Altar ,  Malcolm Taylor ,  Derek Hook ,  Michael Palfreyman

发明人： Charles Altar ,  Malcolm Taylor ,  Derek Hook ,  Michael Palfreyman

IPC分类号： A61K31/495 ,  C07D241/04

CPC分类号： C07D213/69 ,  C07C211/42 ,  C07C255/53 ,  C07C2603/42 ,  C07D211/22 ,  C07D213/74 ,  C07D217/20 ,  C07D221/18 ,  C07D223/16 ,  C07D295/092 ,  C07D295/116 ,  C07D295/13 ,  C07D495/04

摘要： Dual action compounds are provided that are inhibitors of catechol-omethyltransferase (COMT) enzyme and are also partial agonists or antagonists of the D2 receptor, or agonists of the D1 receptor, or interact in these ways with both D1 and D2 receptors. Use of the compounds for treating neuropsychiatric disorders, particularly schizophrenia and mild cognitive impairment, is also described.

摘要翻译： 提供了双作用化合物，其是儿茶酚 - 甲基转移酶（COMT）酶的抑制剂，也是D2受体的部分激动剂或拮抗剂或D1受体的激动剂，或者以这些方式与D1和D2受体相互作用。 还描述了用于治疗神经精神障碍，特别是精神分裂症和轻度认知障碍的化合物的用途。

公开(公告)号：US20070100317A1

公开(公告)日：2007-05-03

申请号：US11586818

申请日：2006-10-25

申请人： Gregory Fischer ,  Malcolm Taylor ,  Edward Kolvek

发明人： Gregory Fischer ,  Malcolm Taylor ,  Edward Kolvek

IPC分类号： A61N1/30 ,  A61M31/00

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： An iontophoretic drug delivery device storage apparatus and a method of using that device is disclosed. The device comprises a fluid reservoir, an electrode assembly and a tray apparatus. The fluid reservoir is capable of retaining a medicament and has a sealed fluid chamber defined by at least one seal. The seal includes a weaker region and a pinch-like configuration associated with that region such that application of pressure to the fluid reservoir breaks the weaker region of the seal, releasing the retained medicament. The electrode assembly comprises an active electrode, at least two passive electrodes a medicament carrying region, and a moat region around the medicament carrying region so that once fluid is delivered from the fluid reservoir to the electrode assembly the fluid is substantially retained in the medicament carrying means.

摘要翻译： 公开了一种离子电渗药物输送装置的储存装置及其使用方法。 该装置包括流体储存器，电极组件和托盘装置。 流体储存器能够保持药物并且具有由至少一个密封件限定的密封流体室。 密封件包括与该区域相关联的较弱区域和夹紧形状，使得向流体储存器施加压力破坏密封件的较弱区域，释放保留的药剂。 电极组件包括有源电极，至少两个钝化电极，药物承载区域，以及围绕药物承载区域的护城河区域，使得一旦流体从流体储存器输送到电极组件，流体基本上保留在携带 手段。

公开(公告)号：US20050189332A1

公开(公告)日：2005-09-01

申请号：US11105635

申请日：2005-04-14

申请人： Brian Farrell ,  Paul Jaynes ,  Malcolm Taylor

发明人： Brian Farrell ,  Paul Jaynes ,  Malcolm Taylor

IPC分类号： H01L21/50 ,  H01L23/04 ,  H01L23/06 ,  H01L23/10 ,  B23K26/20

CPC分类号： H01L21/00 ,  H01L21/50 ,  H01L23/02 ,  H01L23/04 ,  H01L23/06 ,  H01L23/10 ,  H01L24/97 ,  H01L2924/01006 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01077 ,  H01L2924/09701 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/16152 ,  H01L2924/16153 ,  Y10T29/49126 ,  H01L2924/00

摘要： A method of manufacturing a package including manufacturing a substrate to include at least one layer of LCP material, manufacturing a cover made of LCP material to include a lower lip, and sealing the cover to the substrate by heating the interface between the lower lip and the substrate.

摘要翻译： 一种制造包装的方法，其包括制造基材以包括至少一层LCP材料，制造由LCP材料制成的盖以包括下唇，并且通过加热下唇和下唇之间的界面将盖密封到基底上 基质。