公开(公告)号：US20170224584A1

公开(公告)日：2017-08-10

申请号：US15394715

申请日：2016-12-29

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Stacy Greiner Chambliss ,  Marvin Van Every

IPC: A61H39/00 ,  A61N1/36 ,  A61N1/375 ,  A61N1/05

CPC classification number: A61H39/002 ,  A61H2201/164 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36175 ,  A61N1/3756

Abstract: An exemplary electroacupuncture device includes a central electrode of a first polarity centrally located on a surface of a housing of the electroacupuncture device and an annular electrode of a second polarity that is spaced apart from the central electrode. The electroacupuncture device is implanted beneath a skin surface of a patient at an acupoint corresponding to a tibial nerve and performs methods for treating overactive bladder in the patient. One exemplary method performed by the electroacupuncture device includes generating stimulation sessions each including a series of stimulation pulses and having a duty cycle less than 0.05, wherein the duty cycle is a ratio of a duration of each stimulation session to a rate at which each stimulation session occurs. The exemplary method also includes applying the stimulation sessions to the tibial nerve by way of the central electrode and the annular electrode in accordance with the duty cycle.

公开(公告)号：US20170135898A1

公开(公告)日：2017-05-18

申请号：US15421294

申请日：2017-01-31

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy Greiner Chambliss

IPC: A61H39/00 ,  A61F5/00 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of a saphenous nerve and a peroneal nerve of the patient by way of an electrode array located within the patient at an acupoint corresponding to at least one of the saphenous nerve and the peroneal nerve.

公开(公告)号：US09433788B2

公开(公告)日：2016-09-06

申请号：US14669155

申请日：2015-03-26

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/372 ,  A61H39/00 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61H39/00 ,  A61H2201/01 ,  A61N1/3606 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3782 ,  A61N1/3787 ,  Y10T29/49002

Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7, and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低功耗周期和精细的电源管理可以使IEAD在几年内完成其预期功能。

公开(公告)号：US09327134B2

公开(公告)日：2016-05-03

申请号：US13796314

申请日：2013-03-12

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61N1/36067 ,  A61N1/36096 ,  A61N1/36107 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  H01L2224/48091 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US09198828B2

公开(公告)日：2015-12-01

申请号：US13630322

申请日：2012-09-28

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/05 ,  A61H39/00 ,  A61N1/36 ,  A61N1/375 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61N1/36096 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3处施加的刺激脉冲来治疗抑郁症，双相情感障碍或焦虑症。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20150321007A1

公开(公告)日：2015-11-12

申请号：US14805355

申请日：2015-07-21

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/05

CPC classification number: A61N1/0504 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10S128/907

Abstract: A method of treating hypertension in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location by way of the central electrode and the annular electrode in accordance with the duty cycle.

Abstract translation: 一种治疗患者的高血压的方法包括：通过植入患者皮肤表面下方的针刺装置，在对应于患者内的目标组织位置的穴位，产生小于0.05的占空比的刺激会话， 其特征在于，所述占空比为T3〜T4的比例，所述刺激对象中包含的每个刺激对象具有T3分钟的持续时间，以T4分钟为单位的速度发生，所述电针装置包括第一极性的中心电极， 第二极性的环形电极，与中心电极间隔开; 以及2）通过电针装置根据占空比通过中心电极和环形电极施加刺激会话到目标组织位置。

公开(公告)号：US08938297B2

公开(公告)日：2015-01-20

申请号：US13622497

申请日：2012-09-19

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/05 ,  A61N1/362

CPC classification number: A61N1/362 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

Abstract: An implantable electroacupuncture device (IEAD) treats heart failure, coronary artery disease, myocardial ischemia or angina through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio of T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3施加的刺激脉冲来治疗心力衰竭，冠状动脉疾病，心肌缺血或心绞痛。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 T3 / T4的占空比或比例非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20150012056A1

公开(公告)日：2015-01-08

申请号：US14446512

申请日：2014-07-30

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0504 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10S128/907

Abstract: Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.

Abstract translation: 公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。 电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。 在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。 器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。 在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。 这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。

公开(公告)号：US20140214134A1

公开(公告)日：2014-07-31

申请号：US13779155

申请日：2013-02-27

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36139 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

Abstract: A closed loop electroacupuncture (EA) system monitors any change in sympathetic drive within the body of a patient undergoing EA stimulation. The sensed change in sympathetic drive is then used to adjust at least one parameter of the EA stimulation regimen in an appropriate manner that assists regulation of the patient's autonomic nervous system (ANS). One manner of determining an increase in sympathetic drive is to monitor the body temperature at the skin. A decrease in skin temperature is indicative of increased sympathetic drive and/or exercise stress due to vasoconstriction in the subcutaneous vascular bed. An adjunct to monitoring skin temperature is to monitor subcutaneous tissue impedance. Subcutaneous tissue impedance increases during vasoconstriction. Thus, a sensed change in tissue impedance may be used by itself, or as a compliment to sensed changes in temperature, to provide feedback within the closed loop EA system to adjust the stimulation regimen.

Abstract translation: 闭环电针（EA）系统监测经历EA刺激的患者体内的交感神经驱动变化。 然后，感觉到的交感神经驱动变化用于以适当的方式调整EA刺激方案的至少一个参数，这有助于调节患者的自主神经系统（ANS）。 确定交感神经驱动力增加的一种方法是监测皮肤的体温。 皮肤温度的降低表示由于皮下血管床中的血管收缩引起的交感神经驱动和/或运动压力增加。 监测皮肤温度的辅助工具是监测皮下组织阻抗。 血管收缩期皮下组织阻抗增加。 因此，感觉到的组织阻抗的变化本身可以被使用，或者作为感测温度变化的补充，以在闭环EA系统内提供反馈以调整刺激方案。

公开(公告)号：US20140214133A1

公开(公告)日：2014-07-31

申请号：US13777901

申请日：2013-02-26

Applicant: VALENCIA TECHNOLOGIES CORPORATION

Inventor： Chuladatta H. Thenuwara ,  David K. L. Peterson

IPC: A61N1/375

CPC classification number: A61N1/375 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3754 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医学状况。 在优选的实施方案中，IEAD是可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。