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93 条记录 (耗时 0.027 秒)

    Disubstituted triphenylmethylmidazoles for treating mycotic infections
    56.
    发明授权
    Disubstituted triphenylmethylmidazoles for treating mycotic infections 失效
    用于治疗肌肉感染的三甲基甲酰胺

    公开(公告)号：US4117142A

    公开(公告)日：1978-09-26

    申请号：US726568

    申请日：1976-09-27

    申请人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    IPC分类号： C07D521/00 ,  A61K31/415

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro,Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, andZ is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen,Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.

    1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses
    57.
    发明授权
    1-Propyl-triazolyl antimycotic compositions and methods of treating mycoses 失效
    1-丙基 - 三唑基抗真菌组合物和治疗真菌病的方法

    公开(公告)号：US4079142A

    公开(公告)日：1978-03-14

    申请号：US638754

    申请日：1975-12-08

    申请人： Karl Heinz Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Wolfgang Kramer ,  Manfred Plempel

    IPC分类号： C07D249/08 ,  A61K31/41

    CPC分类号： C07D249/08

    摘要： Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable non-toxic inert diluent or carrier.

    摘要翻译： 制备药物组合物，其包含抗真菌有效量的下式化合物或其药学上可接受的无毒盐，其中R 1是未取代或取代的芳基部分，R 2是氢，烷基，烯基，环烷基，未取代的或未取代的 取代的芳基或未取代或取代的芳烷基，并且R 3是氢，烷基或环烷基，当R3是氢时，R2不能是氢，与药学上可接受的无毒惰性稀释剂或载体组合。