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    Preferred ADI/R: a permanent pacing mode to eliminate ventricular pacing while maintaining backup support
    51.
    发明授权
    Preferred ADI/R: a permanent pacing mode to eliminate ventricular pacing while maintaining backup support 有权
    优选的ADI / R：一种永久起搏模式，可在维持备用支持的同时消除心室起搏

    公开(公告)号：US07957800B2

    公开(公告)日：2011-06-07

    申请号：US11550035

    申请日：2006-10-17

    申请人： David A. Casavant ,  Paul Belk ,  Thomas J. Mullen ,  John C. Stroebel

    发明人： David A. Casavant ,  Paul Belk ,  Thomas J. Mullen ,  John C. Stroebel

    IPC分类号： A61N1/368

    CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/3688

    摘要： A preferred atrial-based pacing method and apparatus is provided using an intelligent cardiac pacing system to having the ability to continue atrial-based pacing as long as relatively reliable AV conduction is present. In the event that such relatively reliable AV conduction is not present, mode switching to a DDD/R or a DDI/R pacing mode while continually biased to mode switch back to atrial-based pacing. The standard or relatively reliable AV conduction may be changed either automatically or manually. This increases pacing that utilizes natural AV conduction however possible so as to gain all the benefits of cardiac contractile properties resulting therefrom, while tolerating the occasional missed ventricular depolarization (i.e., non-conducted P-wave). In the event where relatively reliable AV conduction is not present, the pacing mode is switched to a DDD/R mode while detecting a return of the relatively reliable AV conduction (and resulting mode switch to preferred atrial based pacing).

    摘要翻译： 只要存在相对可靠的AV传导，使用智能心脏起搏系统提供优选的基于心房的起搏方法和装置，以具有继续心房起搏的能力。 在不存在这种相对可靠的AV传导的情况下，模式切换到DDD / R或DDI / R起搏模式，同时不断偏向模式切换回基于心房的起搏。 标准或相对可靠的AV传导可以自动或手动改变。 这增加了使用自然AV传导的起搏，尽可能地获得心脏收缩性质的所有益处，同时容忍偶尔的心室去极化（即，未传导的P波）。 在不存在相对可靠的AV导通的情况下，起搏模式被切换到DDD / R模式，同时检测到相对可靠的AV导通的返回（并且导致的模式切换到优选的心房起搏）。

    Method and apparatus for determining excitation-physiologic response delays
    54.
    发明授权
    Method and apparatus for determining excitation-physiologic response delays 有权
    用于确定激发 - 生理反应延迟的方法和装置

    公开(公告)号：US07672715B2

    公开(公告)日：2010-03-02

    申请号：US11343753

    申请日：2006-01-31

    申请人： Rajan Prakash ,  Edward Chinchoy ,  Thomas J. Mullen

    发明人： Rajan Prakash ,  Edward Chinchoy ,  Thomas J. Mullen

    IPC分类号： A61B5/04

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3682

    摘要： An implantable medical device system and associated method are provided for measuring an excitation-physiological response delay. The method includes sensing a first signal responsive to electrical activity in a first cardiac chamber, sensing a second signal responsive to a physiologic response to the electrical activity in the first cardiac chamber; and determining an excitation-physiologic response delay in response to the first signal and the second signal.

    摘要翻译： 提供了一种用于测量激发 - 生理反应延迟的可植入医疗装置系统和相关方法。 所述方法包括响应于第一心室中的电活动来感测第一信号，感测响应于对第一心室中的电活动的生理反应的第二信号; 以及响应于所述第一信号和所述第二信号确定激发 - 生理响应延迟。

    APPARATUS AND METHODS OF OPTIMIZING ATRIOVENTRICULAR PACING DELAY INTERVALS
    56.
    发明申请
    APPARATUS AND METHODS OF OPTIMIZING ATRIOVENTRICULAR PACING DELAY INTERVALS 有权
    优化ATRIOVENTRICULAR PACING DELAY INTERVALS的装置和方法

    公开(公告)号：US20090234411A1

    公开(公告)日：2009-09-17

    申请号：US12047876

    申请日：2008-03-13

    申请人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen

    发明人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/375 ,  A61N1/3752 ,  A61N1/3756

    摘要： Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval based upon ECG-based optimization is calculated as a linear function of P-wave duration, sensed PR (intrinsic) interval, sensed or paced QRS duration and heart rate. Since the relationship among these parameters is linear, once the coefficients are solved (which can be any value, including null) with reference to a known optimized AV interval (AVopt) such as from an echocardiographic study, an AVopt value can be dynamically adjusted in an ambulatory subject. The various combinations of values can be loaded into a look up table or calculated automatically. And, since some of the parameters do not typically change much over time they can be determined acutely and fed into the equation while the other values can be measured frequently. The parameter values can be measured by an implantable medical device such as a dual- or triple-chamber pacemaker.

    摘要翻译： 提供了用于优化基于ECG的优化的房室（AV）起搏延迟间隔的方法和装置，其被计算为P波持续时间，感测的PR（固有）间隔，感测或节奏QRS持续时间和心率的线性函数。 由于这些参数之间的关系是线性的，所以参考已知的优化AV间隔（AVopt）（例如来自超声心动图研究），一旦系数被解决（其可以是包括空值的任何值）可以动态调整AVopt值 一个流动的主题。 值的各种组合可以加载到查找表中或自动计算。 并且，由于一些参数通常不会随着时间而变化很大，因此它们可以被急剧地确定并且被馈送到方程式中，而可以频繁地测量其它值。 参数值可以通过诸如双室或三室起搏器的可植入医疗装置来测量。

    Preferred ADI/R: a permanent pacing mode to eliminate ventricular pacing while maintaining backup support
    57.
    发明授权
    Preferred ADI/R: a permanent pacing mode to eliminate ventricular pacing while maintaining backup support 有权
    优选的ADI / R：一种永久起搏模式，可在维持备用支持的同时消除心室起搏

    公开(公告)号：US07587242B2

    公开(公告)日：2009-09-08

    申请号：US11427571

    申请日：2006-06-29

    申请人： David A. Casavant ,  Paul A. Belk ,  Thomas J. Mullen ,  John C. Stroebel

    发明人： David A. Casavant ,  Paul A. Belk ,  Thomas J. Mullen ,  John C. Stroebel

    IPC分类号： A61N1/365

    CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/3688

    摘要： A preferred atrial-based pacing method and apparatus is provided using an intelligent cardiac pacing system to having the ability to continue atrial-based pacing as long as relatively reliable AV conduction is present. In the event that such relatively reliable AV conduction is not present, mode switching to a DDD/R or a DDI/R pacing mode while continually biased to mode switch back to atrial-based pacing. The standard or relatively reliable AV conduction may be changed either automatically or manually. This increases pacing that utilizes natural AV conduction however possible so as to gain all the benefits of cardiac contractile properties resulting therefrom, while tolerating the occasional missed ventricular depolarization (i.e., non-conducted P-wave). In the event where relatively reliable AV conduction is not present, the pacing mode is switched to a DDD/R mode while detecting a return of the relatively reliable AV conduction (and resulting mode switch to preferred atrial based pacing).

    摘要翻译： 只要存在相对可靠的AV传导，使用智能心脏起搏系统提供优选的基于心房的起搏方法和装置，以具有继续心房起搏的能力。 在不存在这种相对可靠的AV传导的情况下，模式切换到DDD / R或DDI / R起搏模式，同时不断偏向模式切换回基于心房的起搏。 标准或相对可靠的AV传导可以自动或手动改变。 这增加了使用自然AV传导的起搏，尽可能地获得心脏收缩性质的所有益处，同时容忍偶尔的心室去极化（即，未传导的P波）。 在不存在相对可靠的AV导通的情况下，起搏模式被切换到DDD / R模式，同时检测到相对可靠的AV导通的返回（并且导致的模式切换到优选的心房起搏）。

    Apparatus and methods of energy efficient, atrial-based Bi-ventricular fusion-pacing
    59.
    发明授权
    Apparatus and methods of energy efficient, atrial-based Bi-ventricular fusion-pacing 有权
    节能，基于心房的双心室融合起搏的装置和方法

    公开(公告)号：US07181284B2

    公开(公告)日：2007-02-20

    申请号：US10803570

    申请日：2004-03-17

    申请人： John E. Burnes ,  Thomas J. Mullen

    发明人： John E. Burnes ,  Thomas J. Mullen

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： The bi-ventricular implantable pulse generator described and depicted herein enables hemodynamic efficiencies for patients suffering from intraventricular conduction delays or conduction blockage. The pulse generator effectively overcomes such conduction delay or block (e.g., left bundle branch block, “LBBB,” or right bundle branch block, “RBBB”) by delivering a novel form of cardiac resynchronization therapy (CRT). Specifically, a single ventricular pre-excitation pacing stimulus is triggered from an atrial event (e.g., intrinsic or evoked depolarization). The triggering event may emanate from the right atrium (RA) or the left atrium (LA). A single ventricular pre-excitation pacing stimulus is delivered prior to the intrinsic depolarization of the other ventricle and thus promotes intraventricular electromechanical synchrony during CRT delivery.

    摘要翻译： 本文描述和描述的双心室可植入脉冲发生器能够对患有心室内传导延迟或传导阻塞的患者进行血液动力学效率。 通过递送心脏再同步治疗（CRT）的新形式，脉冲发生器有效地克服了这种传导延迟或阻滞（例如左束支传导阻滞“LBBB”或右束支传导阻滞“RBBB”）。 具体来说，从心房事件（例如内在或诱发的去极化）触发单个心室预激发起搏刺激。 触发事件可能从右心房（RA）或左心房（LA）发出。 在另一个心室的内在去极化之前输送单个心室预激励起搏刺激，从而在CRT输送期间促进脑室内机电同步。