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72 条记录 (耗时 0.045 秒)

    SYK-UBP proteins, compositions and methods of use
    51.
    发明授权
    SYK-UBP proteins, compositions and methods of use 有权
    SYK-UBP蛋白，组合物和使用方法

    公开(公告)号：US06709839B1

    公开(公告)日：2004-03-23

    申请号：US09404967

    申请日：1999-09-24

    申请人： Ying Luo ,  Helena Mancebo

    发明人： Ying Luo ,  Helena Mancebo

    IPC分类号： C12N1512

    CPC分类号： C07K14/47

    摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    PCNA associated cell cycle proteins, compositions and methods of use
    52.
    发明授权
    PCNA associated cell cycle proteins, compositions and methods of use 有权
    PCNA相关细胞周期蛋白，组合物和使用方法

    公开(公告)号：US06696263B1

    公开(公告)日：2004-02-24

    申请号：US09404408

    申请日：1999-09-23

    申请人： Ying Luo ,  Betty Huang

    发明人： Ying Luo ,  Betty Huang

    IPC分类号： G01N33566

    CPC分类号： C07K16/40 ,  G01N33/5011

    摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    Exo1 and Exo2, exocytotic proteins
    53.
    发明授权
    Exo1 and Exo2, exocytotic proteins 有权
    Exo1和Exo2，胞吐蛋白

    公开(公告)号：US06623980B1

    公开(公告)日：2003-09-23

    申请号：US09255920

    申请日：1999-02-23

    申请人： Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

    发明人： Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

    IPC分类号： G01N33566

    CPC分类号： C07K14/4703

    摘要： The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    Tankyrase H, compositions involved in the cell cycle and methods of use
    55.
    发明授权
    Tankyrase H, compositions involved in the cell cycle and methods of use 失效
    催乳素酶H，参与细胞周期的组合和使用方法

    公开(公告)号：US06589725B1

    公开(公告)日：2003-07-08

    申请号：US09427154

    申请日：1999-10-25

    申请人： Ying Luo ,  Eva Chan ,  Xiang Xu ,  Betty Huang

    发明人： Ying Luo ,  Eva Chan ,  Xiang Xu ,  Betty Huang

    IPC分类号： C12Q100

    CPC分类号： C12N9/1077 ,  A61K38/00 ,  C12N2310/111

    摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    Nucleic acids encoding RIP3 associated cell cycle proteins
    56.
    发明授权
    Nucleic acids encoding RIP3 associated cell cycle proteins 有权
    编码RIP3相关细胞周期蛋白的核酸

    公开(公告)号：US06428980B1

    公开(公告)日：2002-08-06

    申请号：US09441039

    申请日：1999-11-16

    申请人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

    发明人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

    IPC分类号： C12N510

    CPC分类号： C12N9/1205 ,  C07K14/4738 ,  C07K16/18

    摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    PCNA-associated cell cycle proteins, compositions and methods of use
    57.
    发明授权
    PCNA-associated cell cycle proteins, compositions and methods of use 有权
    PCNA相关细胞周期蛋白，组合物和使用方法

    公开(公告)号：US06387658B1

    公开(公告)日：2002-05-14

    申请号：US09404627

    申请日：1999-09-23

    申请人： Ying Luo ,  Betty Huang

    发明人： Ying Luo ,  Betty Huang

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  C07K14/4738

    摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

    Methods and compositions for transferring DNA sequence information among vectors
    58.
    发明授权
    Methods and compositions for transferring DNA sequence information among vectors 失效
    用于在载体之间转移DNA序列信息的方法和组合物

    公开(公告)号：US5989872A

    公开(公告)日：1999-11-23

    申请号：US909525

    申请日：1997-08-12

    申请人： Ying Luo ,  Shaobing Hua ,  Li Zhu

    发明人： Ying Luo ,  Shaobing Hua ,  Li Zhu

    IPC分类号： C12N15/81 ,  C12P19/34 ,  C07H21/04 ,  C12N15/64 ,  C12N15/85

    CPC分类号： C12N15/81

    摘要： Methods and compositions are provided for transferring DNA sequence information from a first vector to a second vector. In the subject methods, a first vector comprising a region of DNA having a sequence of interest is contacted with a set of three pairs of oligonucleotide primers under conditions sufficient to produce three different PCR products, where each product corresponds to a different reading frame. The oligonucleotide primers comprise a first region of sequence identity with the first vector and a second region permissive of site specific recombination with the second vector. The resultant PCR products are combined with the second vector under conditions sufficient for site specific recombination to occur. Also provided are kits for use in performing the subject methods.

    摘要翻译： 提供了将DNA序列信息从第一载体转移到第二载体的方法和组合物。 在本主题方法中，将包含具有感兴趣序列的DNA区域的第一载体与一组三对寡核苷酸引物在足以产生三种不同PCR产物的条件下接触，其中每个产物对应于不同的阅读框。 寡核苷酸引物包含与第一载体具有序列同一性的第一区域和允许与第二载体进行位点特异性重组的第二区域。 将得到的PCR产物与足以进行位点特异性重组的条件与第二载体组合。 还提供了用于执行受试方法的试剂盒。

    Method and system for image resizing based on interpolation enhanced seam operations
    59.
    发明授权
    Method and system for image resizing based on interpolation enhanced seam operations 有权

    公开(公告)号：US09741092B2

    公开(公告)日：2017-08-22

    申请号：US12998387

    申请日：2008-10-29

    申请人： Ying Luo ,  Ju Guo

    发明人： Ying Luo ,  Ju Guo

    IPC分类号： G06K9/32 ,  G06T3/00

    CPC分类号： G06T3/0012

    摘要： Methods and systems for resizing an image utilizing content-aware seam operations include defining low-energy seams defining contextually less-important information and utilizing such information for interpolation based on one-dimensional manifolds. The interpolation can form new seams and/or regenerated pixels that can be combined with the image to provide a content-aware resized image exhibiting smooth and continuous features.