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公开(公告)号：US07488805B2
公开(公告)日：2009-02-10
申请号：US11739267
申请日：2007-04-24
Applicant: Ying Luo , Betty Huang , Mary Shen , Pei Wen Yu
Inventor： Ying Luo , Betty Huang , Mary Shen , Pei Wen Yu
IPC: C07K16/00
CPC classification number: C07K14/4747 , A61K38/00
Abstract: The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。
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2.发明授权公开(公告)号：US07420045B1
公开(公告)日：2008-09-02
申请号：US10130555
申请日：2000-11-17
Applicant: Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
Inventor： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
CPC classification number: C07K14/4747 , A61K38/00
Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also, provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 此外，本文提供的是包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及用于产生本发明多肽的方法 本发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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公开(公告)号：US07223850B1
公开(公告)日：2007-05-29
申请号：US09762491
申请日：1999-08-06
Applicant: Ying Luo , Betty Huang , Mary Shen , Pei Wen Yu
Inventor： Ying Luo , Betty Huang , Mary Shen , Pei Wen Yu
CPC classification number: C12N9/12
Abstract: The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及新的凋亡多肽，例如涉及调节凋亡的Apop1和Apop3蛋白和相关分子以及编码那些多肽的核酸分子。 此处还提供了包含这些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明进一步提供了用于鉴定调节Apop1，Apop2和Apop3的生物活性的新组合物的方法，以及这些组合物在诊断和治疗疾病中的用途。
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公开(公告)号：US07863222B2
公开(公告)日：2011-01-04
申请号：US12221325
申请日：2008-08-01
Applicant: Donald G. Payan , Mary Shen , Simon Yu , Todd M. Kinsella , Yasumichi Hitoshi
Inventor： Donald G. Payan , Mary Shen , Simon Yu , Todd M. Kinsella , Yasumichi Hitoshi
CPC classification number: C12N15/1093 , C12N15/66 , C12P19/34 , C40B40/08 , C40B50/06
Abstract: As noted above, certain aspects of this disclosure relate to a library of nucleic acid vectors, as well as a method for making the same. In certain embodiments, the library of nucleic acid vectors comprises: a plurality of nucleic acid molecules of the following formula: S1—R—S2 wherein, in each nucleic acid of the plurality: S1 and S2 are each at least 15 nucleotides in length; S1 and S2 are complementary to each other along their entire length; either S1 or S2 is complementary along its entire length to a sequence in eukaryotic mRNA; and R is a six base recognition site for a restriction endonuclease; and wherein S1 and S2 vary in nucleotide sequence between different members of the plurality. A method for amplifying a circular nucleic acid is also provided.
Abstract translation: 如上所述，本公开的某些方面涉及核酸载体文库以及其制备方法。 在某些实施方案中，核酸载体文库包含：多个下式的核酸分子：S1-R-S2，其中在多个的每个核酸中，S1和S2的长度各自为至少15个核苷酸; S1和S2沿其整个长度彼此互补; S1或S2在其整个长度上与真核mRNA中的序列互补; R是限制性内切核酸酶的六碱基识别位点; 并且其中S1和S2在多个不同成员之间的核苷酸序列变化。 还提供了扩增环状核酸的方法。
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5.发明授权Directionally cloned random cDNA expression vector libraries, compositions and methods of use 有权定向克隆的随机cDNA表达载体文库，组合物和使用方法公开(公告)号：US06808906B2
公开(公告)日：2004-10-26
申请号：US10142662
申请日：2002-05-08
Applicant: Mary Shen , Simon Yu , Xian Wu , Donald Payan
Inventor： Mary Shen , Simon Yu , Xian Wu , Donald Payan
IPC: C12N1566
CPC classification number: C12N15/86 , C12N15/66 , C12N2740/13043 , C12N2800/70 , C12Q1/6855 , C12Q2525/185
Abstract: The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.
Abstract translation: 本发明提供随机cDNA表达载体文库，其包含表达载体，其包含位于正义取向的随机cDNA。 还提供了随机cDNA表达载体文库，其包含表达载体，其包含以反义方向定位的随机cDNA。 还提供了通过定向克隆随机cDNA产生这些文库的方法。 本文还提供了使用这些文库筛选能够以期望的方式调节细胞表型的试剂的方法。
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Patent Agency Ranking
6.发明授权公开(公告)号：US07423118B1
公开(公告)日：2008-09-09
申请号：US09715725
申请日：2000-11-16
Applicant: Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
Inventor： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
IPC: C07K14/00
CPC classification number: C07K14/4747 , A61K38/00
Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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公开(公告)号：US20080021202A1
公开(公告)日：2008-01-24
申请号：US11739267
申请日：2007-04-24
Applicant: Ying Luo , Betty Huang , Mary Shen , Pei Yu
Inventor： Ying Luo , Betty Huang , Mary Shen , Pei Yu
IPC: C07K16/18
CPC classification number: C07K14/4747 , A61K38/00
Abstract: The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。
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公开(公告)号：US06623980B1
公开(公告)日：2003-09-23
申请号：US09255920
申请日：1999-02-23
Applicant: Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
Inventor： Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
IPC: G01N33566
CPC classification number: C07K14/4703
Abstract: The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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公开(公告)号：US06428980B1
公开(公告)日：2002-08-06
申请号：US09441039
申请日：1999-11-16
Applicant: Ying Luo , PeiWen Yu , Mary Shen , Betty Huang
Inventor： Ying Luo , PeiWen Yu , Mary Shen , Betty Huang
IPC: C12N510
CPC classification number: C12N9/1205 , C07K14/4738 , C07K16/18
Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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公开(公告)号：US20100029505A1
公开(公告)日：2010-02-04
申请号：US12221325
申请日：2008-08-01
Applicant: Donald G. Payan , Mary Shen , Simon Yu , Todd M. Kinsella , Yasumichi Hitoshi
Inventor： Donald G. Payan , Mary Shen , Simon Yu , Todd M. Kinsella , Yasumichi Hitoshi
CPC classification number: C12N15/1093 , C12N15/66 , C12P19/34 , C40B40/08 , C40B50/06
Abstract: As noted above, certain aspects of this disclosure relate to a library of nucleic acid vectors, as well as a method for making the same. In certain embodiments, the library of nucleic acid vectors comprises: a plurality of nucleic acid molecules of the following formula: S1—R—S2 wherein, in each nucleic acid of the plurality: S1 and S2 are each at least 15 nucleotides in length; S1 and S2 are complementary to each other along their entire length; either S1 or S2 is complementary along its entire length to a sequence in eukaryotic mRNA; and R is a six base recognition site for a restriction endonuclease; and wherein S1 and S2 vary in nucleotide sequence between different members of the plurality. A method for amplifying a circular nucleic acid is also provided.
Abstract translation: 如上所述，本公开的某些方面涉及核酸载体文库以及其制备方法。 在某些实施方案中，核酸载体文库包含：多个下式的核酸分子：S1-R-S2，其中在多个的每个核酸中，S1和S2的长度各自为至少15个核苷酸; S1和S2沿其整个长度彼此互补; S1或S2在其整个长度上与真核mRNA中的序列互补; R是限制性内切核酸酶的六碱基识别位点; 并且其中S1和S2在多个不同成员之间的核苷酸序列变化。 还提供了扩增环状核酸的方法。
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