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119 条记录 (耗时 0.047 秒)

    Quinazoline derivatives as kinase inhibitors
    51.
    发明授权
    Quinazoline derivatives as kinase inhibitors 失效
    喹唑啉衍生物作为激酶抑制剂

    公开(公告)号：US06982266B2

    公开(公告)日：2006-01-03

    申请号：US10344736

    申请日：2001-08-17

    申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    IPC分类号： A01K31/675 ,  A01K31/517 ,  C07D43/02 ,  C07D239/72

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法 ，血管重构，癌症和肾小球硬化症。

    Nitrogenous heterocyclic substituted quinoline compounds
    52.
    发明授权
    Nitrogenous heterocyclic substituted quinoline compounds 有权
    氮杂环取代喹啉化合物

    公开(公告)号：US06960580B2

    公开(公告)日：2005-11-01

    申请号：US10094191

    申请日：2002-03-08

    申请人： Robert M. Scarborough ,  Anjali Pandey

    发明人： Robert M. Scarborough ,  Anjali Pandey

    IPC分类号： C07D215/46 ,  C07D215/54 ,  C07D401/12 ,  A61K31/496 ,  A61P35/00

    CPC分类号： C07D401/12 ,  C07D215/46 ,  C07D215/54

    摘要： The present invention relates to nitrogen-containing heterocyclic quinoline compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. More particularly, the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环喹啉化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 更具体地说，本发明提供了抑制PDGF受体的磷酸化阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重构的方法 ，癌症和肾小球硬化症。

    Nitrogenous heterocylic compounds
    53.
    发明授权
    Nitrogenous heterocylic compounds 失效
    含氮杂环化合物

    公开(公告)号：US06956039B2

    公开(公告)日：2005-10-18

    申请号：US10344737

    申请日：2001-08-17

    申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    IPC分类号： A61P35/00 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D487/00

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化症。

    PROTEIN KINASE INHIBITORS
    57.
    发明申请
    PROTEIN KINASE INHIBITORS 有权
    蛋白激酶抑制剂

    公开(公告)号：US20090054425A1

    公开(公告)日：2009-02-26

    申请号：US12192034

    申请日：2008-08-14

    申请人： Yonghong Song ,  Qing Xu ,  Anjali Pandey

    发明人： Yonghong Song ,  Qing Xu ,  Anjali Pandey

    IPC分类号： A61K31/496 ,  C07D487/04 ,  A61K31/538 ,  A61P7/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/02 ,  C07D413/14

    CPC分类号： C07D487/04

    摘要： Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase.

    摘要翻译： 具有以下结构的化合物，特别是具有脾酪氨酸激酶（Syk）抑制活性的化合物或其药学上可接受的盐，其中R 1是结构（a），（b），（c）或（d）：和Ra，Rb ，Rc，R2，R3，R4，R5，R6和R7如本文所定义。 还公开了与其制备和使用相关的方法以及含有该组合物的药物组合物，以及其用于治疗由Syk和/或JAK激酶介导的病症或病症的用途。

    Protein kinase inhibitors
    60.
    发明授权
    Protein kinase inhibitors 有权
    蛋白激酶抑制剂

    公开(公告)号：US07705004B2

    公开(公告)日：2010-04-27

    申请号：US12192034

    申请日：2008-08-14

    申请人： Yonghong Song ,  Qing Xu ,  Anjali Pandey

    发明人： Yonghong Song ,  Qing Xu ,  Anjali Pandey

    IPC分类号： C07D487/04 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase.

    摘要翻译： 具有以下结构的化合物，特别是具有脾酪氨酸激酶（Syk）抑制活性的化合物或其药学上可接受的盐，其中R 1是结构（a），（b），（c）或（d）：和Ra，Rb ，Rc，R2，R3，R4，R5，R6和R7如本文所定义。 还公开了与其制备和使用相关的方法以及含有该组合物的药物组合物，以及其用于治疗由Syk和/或JAK激酶介导的病症或病症的用途。