公开(公告)号：US08299125B2

公开(公告)日：2012-10-30

申请号：US12743101

申请日：2008-11-05

申请人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

发明人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

IPC分类号： C07C309/27 ,  A61K31/216 ,  A61K31/192

CPC分类号： C07J63/00 ,  C07J63/008

摘要： The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.

摘要翻译： 本发明公开了具有由式（I）表示的抗肿瘤活性的水溶性三硝基苯酚化合物，其中取代基R 1〜R 4和M如说明书中所定义。 本发明还公开了使用醌甲基化三萜化合物作为原料制备式（I）化合物的方法。 本发明公开的水溶性三萜烯化合物可以制成各种剂型，包括注射剂，片剂，胶囊剂，颗粒剂和搽剂，特别适用于注射。

公开(公告)号：US08290247B2

公开(公告)日：2012-10-16

申请号：US12150817

申请日：2008-05-01

申请人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang ,  Brian Whited ,  Jaroslaw Rossignac

发明人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang ,  Brian Whited ,  Jaroslaw Rossignac

IPC分类号： G06K9/00

CPC分类号： G06K9/342 ,  G06T7/11 ,  G06T2200/04 ,  G06T2207/10072 ,  G06T2207/20101 ,  G06T2207/30101

摘要： A method and system for segmenting tubular structures in 3D images is disclosed. User inputs identifying a first region on the image inside of a tubular structure and a second region of the image outside of the tubular structure are received. Based on this information, an ordered series of pearls are generated along the tubular structure. Pearls are spheres, each having a center location and a radius determined based on the center locations and radii of previous pearls and on local voxel intensities in the image. A continuous model of the tubular structure can be generated by interpolating the center locations and radii of the ordered series of pearls. The ordered series of pearls can be displayed and easily edited in response to user input, thus providing an efficient and flexible method for interactive segmentation of a potion of interest in a tubular structure.

摘要翻译： 公开了一种用于在3D图像中分割管状结构的方法和系统。 接收识别管状结构内部的图像上的第一区域和管状结构外部的图像的第二区域的用户输入。 基于该信息，沿着管状结构产生有序的珍珠系列。 珍珠是球体，每个球体具有基于中心位置和先前珍珠的半径确定的中心位置和半径以及图像中的局部体素强度。 可以通过内插有序系列珍珠的中心位置和半径来生成管状结构的连续模型。 可以根据用户输入显示和容易地编辑有序的珍珠系列，从而为管状结构中感兴趣的药水进行交互式分割提供了一种有效和灵活的方法。

公开(公告)号：US08262923B2

公开(公告)日：2012-09-11

申请号：US12635846

申请日：2009-12-11

申请人： Tong Fang ,  Yunsang S. Kim ,  Andreas Fischer

发明人： Tong Fang ,  Yunsang S. Kim ,  Andreas Fischer

IPC分类号： B44C1/22

CPC分类号： H01L21/3065 ,  H01J37/32366 ,  H01L21/02021

摘要： A method of preventing arcing during bevel edge etching a semiconductor substrate with a plasma in a bevel etcher in which the semiconductor substrate is supported on a semiconductor substrate support comprises bevel edge etching the semiconductor substrate with the plasma in the bevel etcher while evacuating the bevel etcher to a pressure of 3 to 100 Torr while maintaining RF voltage seen at the wafer at a low enough value to avoid arcing.

摘要翻译： 在半导体衬底支撑在半导体衬底支撑件上的斜面蚀刻器中用等离子体进行斜面边缘蚀刻半导体衬底时的防止电弧的方法包括在排除斜面蚀刻器的同时在斜面蚀刻器中等离子体刻蚀半导体衬底 压力为3至100托，同时保持晶片处的RF电压足够低以避免电弧。

公开(公告)号：US08229180B2

公开(公告)日：2012-07-24

申请号：US12603928

申请日：2009-10-22

申请人： Sajjad Hussain Baloch ,  Rupen Melkisetoglu ,  Sergei Azernikov ,  Alexander Zouhar ,  Tong Fang

发明人： Sajjad Hussain Baloch ,  Rupen Melkisetoglu ,  Sergei Azernikov ,  Alexander Zouhar ,  Tong Fang

IPC分类号： G06K9/00

CPC分类号： H04R25/658 ,  G06K9/00201 ,  H04R25/652 ,  H04R2225/77

摘要： A method for detecting anatomical features in 3D ear impressions includes receiving a 3D digital image of a 3D ear impression, obtaining a surface of the ear impression from the 3D image, analyzing the surface with one or more feature detectors, the detectors adapted to detecting generic features, including peak features, concavity features, elbow features, ridge features, and bump features, and derived features that depend on generic features or other derived features, and forming a canonical ear signature from results of the detectors, where the canonical ear signature characterizes the 3D ear impression.

摘要翻译： 用于检测3D耳朵曝光中的解剖特征的方法包括接收3D耳朵印象的3D数字图像，从3D图像获得耳朵印象的表面，用一个或多个特征检测器分析表面，适用于检测通用 特征，包括峰特征，凹陷特征，肘部特征，脊特征和凸起特征，以及取决于一般特征或其他衍生特征的导出特征，以及由检测器的结果形成规范耳朵签名，其中规范耳朵特征表征 3D耳朵的印象。

公开(公告)号：US08086007B2

公开(公告)日：2011-12-27

申请号：US12286970

申请日：2008-10-03

申请人： Michelle Xiao-Hong Yan ,  Ti-chiun Chang ,  Markus Lendl ,  Stefan Boehm ,  Tong Fang ,  Peter Durlak

发明人： Michelle Xiao-Hong Yan ,  Ti-chiun Chang ,  Markus Lendl ,  Stefan Boehm ,  Tong Fang ,  Peter Durlak

IPC分类号： G06K9/00

CPC分类号： G06K9/4619 ,  G06K2209/05 ,  G06T7/0012

摘要： A method and system for image quality assessment is disclosed. The image quality assessment method is a no-reference method for objectively assessing the quality of medical images. This method is guided by the human vision model in order to accurately reflect human perception. A region of interest (ROI) of medical image is divided into non-overlapping blocks of equal size. Each of the blocks is categorized as a smooth block, a texture block, or an edge block. A perceptual sharpness measure, which is weighted by local contrast, is calculated for each of the edge blocks. A perceptual noise level measure, which is weighted by background luminance, is calculated for each of the smooth blocks. A sharpness quality index is determined based on the perceptual sharpness measures of all of the edge blocks, and a noise level quality index is determined based on the perceptual noise level measures of all of the smooth blocks. An overall image quality index can be determined by using task specific machine learning of samples of annotated images. The image quality assessment method can be used in applications, such as video/image compression and storage in healthcare and homeland security, and band-width limited wireless communication.

摘要翻译： 公开了一种用于图像质量评估的方法和系统。 图像质量评估方法是客观评估医学图像质量的非参考方法。 这种方法是以人类视觉模型为指导，以准确反映人类的感知。 医学图像的感兴趣区域（ROI）被划分成相等大小的不重叠块。 每个块被分类为平滑块，纹理块或边缘块。 针对每个边缘块计算出由局部对比度加权的感知锐度度量。 为每个平滑块计算感知噪声水平测量，其由背景亮度加权。 基于所有边缘块的感知锐度测量来确定锐度质量指标，并且基于所有平滑块的感知噪声水平测量来确定噪声水平质量指数。 可以通过使用注释图像的样本的任务特定机器学习来确定整体图像质量指数。 图像质量评估方法可用于医疗保健和国土安全中的视频/图像压缩和存储等应用，以及带宽有限的无线通信。

公开(公告)号：US08069022B2

公开(公告)日：2011-11-29

申请号：US11465628

申请日：2006-08-18

申请人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang

发明人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang

IPC分类号： G06G17/50 ,  G06G7/48 ,  H04R25/00

CPC分类号： G06K9/6206 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/77

摘要： A method and apparatus is disclosed whereby a point on an ear impression model to be labeled is selected and a shape context is determined for that point. This shape context is then compared to average shape contexts for different regions on a reference ear impression model, also referred to herein as an ear impression shape atlas. A cost function is used to determine the minimum cost between the shape context for the selected point and one of the average shape contexts. Once the minimized cost is determined, the region label corresponding to the average shape context having a minimized cost is assigned to that point. In this way, points on the surface of an ear impression are classified and labeled as being located in regions corresponding to the regions on the ear impression shape atlas.

摘要翻译： 公开了一种方法和装置，由此选择要标记的耳朵印象模型上的点，并且为该点确定形状上下文。 然后将该形状上下文与参考耳部印象模型上的不同区域的平均形状上下文进行比较，这里也称为耳朵印象形状图集。 成本函数用于确定所选点的形状上下文与平均形状上下文之间的最小成本。 一旦确定了最小化成本，则将具有最小化成本的平均形状上下文对应的区域标签分配给该点。 以这种方式，将耳朵表面的点分类并标记为位于与耳朵印象形状图集上的区域对应的区域中。

公开(公告)号：US08005652B2

公开(公告)日：2011-08-23

申请号：US11466149

申请日：2006-08-22

申请人： Gozde Unal ,  Gregory G. Slabaugh ,  Tong Fang

发明人： Gozde Unal ,  Gregory G. Slabaugh ,  Tong Fang

IPC分类号： G06F7/60 ,  G06F17/50

CPC分类号： H04R25/658 ,  G06K9/469 ,  H04R25/652 ,  H04R2225/77

摘要： An improved method of designing hearing aid molds is disclosed whereby regions of an ear impression model are identified as a function of a geodesic distance measure. According to a first embodiment, a canal point of an ear impression model is identified as that point having a maximum normalized geodesic distance as compared to all other points on the surface of the ear impression model. According to a second embodiment, a helix point of the ear impression model is identified as that point having a maximum normalized geodesic distance as compared to all points except those points in the canal region of the ear impression model. Finally, in accordance with another embodiment, a geodesic distance between a canal point and a helix point of an ear impression model is identified and a percentage threshold, illustratively 65%, is applied to that geodesic distance to identify a crus region.

摘要翻译： 公开了一种改进的助听器模具的设计方法，其中耳朵印模模型的区域被识别为测地距离测量的函数。 根据第一实施例，与耳朵印象模型的表面上的所有其他点相比，耳朵印模模型的运河点被识别为具有最大归一化测地距离的点。 根据第二实施例，与除了耳朵模型的运河区域中的那些点之外的所有点相比，耳朵印模模型的螺旋点被识别为具有最大归一化测地距离的点。 最后，根据另一个实施例，识别耳朵印模模型的运河点和螺旋点之间的测地距离，并且示例性地将65％的百分比阈值应用于该测地距离以识别小腿区域。

公开(公告)号：US07961944B2

公开(公告)日：2011-06-14

申请号：US11933516

申请日：2007-11-01

申请人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang

发明人： Gregory G. Slabaugh ,  Gozde Unal ,  Tong Fang

IPC分类号： G06K9/34

CPC分类号： G06T17/10

摘要： A method for modeling a 2-dimensional tubular structure in a digitized image includes providing a digitized image of a tubular structure containing a plurality of 2D balls of differing radii, initializing a plurality of connected spline segments that form an envelope surrounding the plurality of 2D balls, each the spline segment Si being parameterized by positions of the ith and i+1th balls and contact angles αi, αi+1 from the center of each respective ball to a point on the perimeter of each the ball contacting the spline segment Si, each the αi affecting spline segment Si and Si−1, and updating the angles by minimizing an energy that is a functional of the angles, where the updating is repeated until the energy is minimized subject to a constraint that the envelope is tangent to each ball at each point of contact, where the envelope is represented by the contact angles.

摘要翻译： 一种用于对数字化图像中的二维管状结构进行建模的方法包括提供包含不同半径的多个2D球的管状结构的数字化图像，初始化形成围绕多个2D球的包围的多个连接的花键片段 每个花键片段Si由第i和第i + 1个球的位置参数化，接触角αi，αi+ 1从每个相应球的中心到接触花键片段Si的每个球的周边上的点，每个 αi影响样条段Si和Si-1，并且通过使作为角度的函数的能量最小化来更新角度，其中重复更新直到能量被最小化，受限于包围与每个球相切的约束 每个接触点，其中信封由接触角表示。

公开(公告)号：US20100103170A1

公开(公告)日：2010-04-29

申请号：US12603928

申请日：2009-10-22

申请人： Sajjad Hussain Baloch ,  Rupen Melkisetoglu ,  Sergei Azernikov ,  Alexander Zouhar ,  Tong Fang

发明人： Sajjad Hussain Baloch ,  Rupen Melkisetoglu ,  Sergei Azernikov ,  Alexander Zouhar ,  Tong Fang

IPC分类号： G06T17/00 ,  G06K9/00

CPC分类号： H04R25/658 ,  G06K9/00201 ,  H04R25/652 ,  H04R2225/77

摘要： A method for detecting anatomical features in 3D ear impressions includes receiving a 3D digital image of a 3D ear impression, obtaining a surface of the ear impression from the 3D image, analyzing the surface with one or more feature detectors, the detectors adapted to detecting generic features, including peak features, concavity features, elbow features, ridge features, and bump features, and derived features that depend on generic features or other derived features, and forming a canonical ear signature from results of the detectors, where the canonical ear signature characterizes the 3D ear impression.

摘要翻译： 用于检测3D耳朵曝光中的解剖特征的方法包括接收3D耳朵印象的3D数字图像，从3D图像获得耳朵印象的表面，用一个或多个特征检测器分析表面，适用于检测通用 特征，包括峰特征，凹陷特征，肘部特征，脊特征和凸起特征，以及取决于一般特征或其他衍生特征的导出特征，以及由检测器的结果形成规范耳朵签名，其中规范耳朵特征表征 3D耳朵的印象。

公开(公告)号：US20100100362A1

公开(公告)日：2010-04-22

申请号：US12573216

申请日：2009-10-05

申请人： Alexander Zouhar ,  Sajjad Baloch ,  Sergei Azernikov ,  Hui Xie ,  Tong Fang

发明人： Alexander Zouhar ,  Sajjad Baloch ,  Sergei Azernikov ,  Hui Xie ,  Tong Fang

IPC分类号： G06F17/10

CPC分类号： G06F17/50 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/55 ,  H04R2225/77

摘要： A method for determining a degree of similarity between ear canal models includes receiving a first mesh model representing an inner surface of a first ear. A set of points is sampled within the first mesh model. Each of the sampled set of points is matched to a corresponding point of a second mesh model representing an inner surface of a second ear. A shape distance between the first mesh model and the second mesh model is calculated based on the matched sets of points. A determination of the degree of similarity between the inner surface of the first ear and the inner surface of the second ear is provided based on the calculated shape distance.

摘要翻译： 用于确定耳道模型之间的相似程度的方法包括接收表示第一耳朵的内表面的第一网格模型。 在第一个网格模型中对一组点进行采样。 每个采样的点集合与表示第二耳朵的内表面的第二网格模型的对应点匹配。 基于匹配的点集合来计算第一网格模型和第二网格模型之间的形状距离。 基于计算出的形状距离来确定第一耳朵的内表面和第二耳朵的内表面之间的相似程度。