公开(公告)号：US06720146B2

公开(公告)日：2004-04-13

申请号：US09970966

申请日：2001-10-02

申请人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

发明人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

IPC分类号： G01N3348

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US06284241B1

公开(公告)日：2001-09-04

申请号：US09221298

申请日：1998-12-23

申请人： Jiangchun Xu

发明人： Jiangchun Xu

IPC分类号： C12N1500

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： Compounds and methods for the treatment and diagnosis of colon cancer are provided. The inventive compounds include polypeptides containing at least a portion of a colon tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of colon cancer comprising such polypeptides, or polynucleotide molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了治疗和诊断结肠癌的化合物和方法。 本发明化合物包括含有至少一部分结肠肿瘤蛋白的多肽。 还提供包含这些多肽的结肠癌免疫治疗用疫苗和药物组合物，或编码这些多肽的多核苷酸分子，以及用于制备本发明多肽的DNA分子。

公开(公告)号：US07939646B2

公开(公告)日：2011-05-10

申请号：US11928369

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C07K2/00

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US20080108070A1

公开(公告)日：2008-05-08

申请号：US11851267

申请日：2007-09-06

申请人： Jiangchun Xu ,  Gordon King ,  Madeleine Braun ,  Ruth Chenault ,  Heather Secrist ,  Susan Harlocker ,  Siqing Wang

发明人： Jiangchun Xu ,  Gordon King ,  Madeleine Braun ,  Ruth Chenault ,  Heather Secrist ,  Susan Harlocker ,  Siqing Wang

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Methods and compositions for the diagnosis and monitoring of colon cancer are disclosed.

摘要翻译： 公开了用于诊断和监测结肠癌的方法和组合物。

公开(公告)号：US06664377B1

公开(公告)日：2003-12-16

申请号：US09688489

申请日：2000-10-13

申请人： Jiangchun Xu

发明人： Jiangchun Xu

IPC分类号： C07K1600

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  C07K14/705 ,  C07K2319/00

摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

公开(公告)号：US06617109B1

公开(公告)日：2003-09-09

申请号：US09713550

申请日：2000-11-14

申请人： Jiangchun Xu ,  John A. Stolk

发明人： Jiangchun Xu ,  John A. Stolk

IPC分类号： C07H2100

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US20080226606A1

公开(公告)日：2008-09-18

申请号：US11928369

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： A61K39/00 ,  C07K14/00 ,  C07K4/00 ,  C07H21/04 ,  C12N15/00 ,  A61K35/00 ,  C12N5/00 ,  C07K16/00 ,  G01N33/574 ,  C12N5/02

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20060193870A1

公开(公告)日：2006-08-31

申请号：US11374388

申请日：2006-03-13

申请人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist ,  Yuqui Jiang

发明人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist ,  Yuqui Jiang

IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C12Q1/6886 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12Q2600/158 ,  G01N33/57419

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

公开(公告)号：US06613515B1

公开(公告)日：2003-09-02

申请号：US09640173

申请日：2000-08-15

申请人： Jiangchun Xu ,  John A. Stolk

发明人： Jiangchun Xu ,  John A. Stolk

IPC分类号： G01N3353

CPC分类号： C07K14/4748 ,  A61K38/00 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Polypeptides and polynucleotides as provided herein may further be used for the detection and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其部分，编码这种部分的多核苷酸或对这种蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 本文提供的多肽和多核苷酸还可用于检测和监测卵巢癌。

公开(公告)号：US06379951B1

公开(公告)日：2002-04-30

申请号：US09118627

申请日：1998-07-17

申请人： Steven G. Reed ,  Jiangchun Xu

发明人： Steven G. Reed ,  Jiangchun Xu

IPC分类号： C07H2104

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00

摘要： Compounds and methods for treating breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了治疗乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 还提供了包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的DNA分子，以及用于制备本发明多肽的DNA分子。